Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6K3T2

Entry ID Method Resolution Chain Position Source
AF-Q6K3T2-F1 Predicted AlphaFoldDB

No variants for Q6K3T2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6K3T2

No associated diseases with Q6K3T2

9 regional properties for Q6K3T2

Type Name Position InterPro Accession
domain SH3 domain 225 - 293 IPR001452
domain PDZ domain 140 - 219 IPR001478
domain L27 domain 8 - 121 IPR004172
domain Guanylate kinase-like domain 350 - 537 IPR008144
domain Guanylate kinase/L-type calcium channel beta subunit 349 - 540 IPR008145
domain L27 domain, C-terminal 12 - 63 IPR014775-1
domain L27 domain, C-terminal 69 - 120 IPR014775-2
conserved_site Guanylate kinase, conserved site 385 - 402 IPR020590
domain MPP2, SH3 domain 229 - 287 IPR035602

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

1 GO annotations of biological process

Name Definition
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60741 HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Homo sapiens (Human) SS
Q9P1Z3 HCN3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Homo sapiens (Human) SS
Q9UL51 HCN2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Homo sapiens (Human) SS
Q9Y3Q4 HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Homo sapiens (Human) EV
O88704 Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Mus musculus (Mouse) SS
O88705 Hcn3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Mus musculus (Mouse) SS
O70507 Hcn4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Mus musculus (Mouse) SS
O88703 Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Mus musculus (Mouse) EV
Q9JKA9 Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Rattus norvegicus (Rat) SS
Q9JKA7 Hcn4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Rattus norvegicus (Rat) SS
Q9JKB0 Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Rattus norvegicus (Rat) SS
Q9JKA8 Hcn3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Rattus norvegicus (Rat) SS
A2ZX97 Os01g0718700 Potassium channel KAT6 Oryza sativa subsp japonica (Rice) PR
Q9SKD7 CNGC3 Probable cyclic nucleotide-gated ion channel 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDR2 CNGC19 Putative cyclic nucleotide-gated ion channel 19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SU64 CNGC16 Probable cyclic nucleotide-gated ion channel 16 Arabidopsis thaliana (Mouse-ear cress) PR
P92960 ATHB-4 Potassium channel KAT3 Arabidopsis thaliana (Mouse-ear cress) PR
Q39128 KAT1 Potassium channel KAT1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTQAHSKSCF HQFWDGLQIK RSSDSFTVEL LPSLGATINH SNKLQKFIIS PYDPRYRSWE
70 80 90 100 110 120
LFLIVLVVYS AWICPFELAF LRDLPSKLLL VENIVDIFFA IDIVLTFFVA YVDSKTHLLV
130 140 150 160 170 180
DDRKRIAMRY LSTWFIFDVC STAPFQPIIL LFTHKGNDIA FKVLNLLRLW RLHRVSSLFA
190 200 210 220 230 240
RLEKDIRFNY FWTRCSKLIS VTLFAVHCAG CFNYMIADRY PNPEKTWIGA VMSTFRSESL
250 260 270 280 290 300
WTRYITALYW SITTLTTTGY GDLHAENPTE MLFDIVYMMF NLGLTAYLIG NMTNLVVHGT
310 320 330 340 350 360
SRTRKFRDSI QAASEFAARN QLPENIKQQV LSHFCLQFKT EGLNQQVMLD CLPKGIRSSI
370 380 390 400 410 420
AYSLFFPIIR QAYLFNGVSG NFIAELVMEV QAEYFPPKED IILQNEGEAD VYIVVSGAVN
430 440 450 460 470 480
IITTIHGNEQ VYEKIAEGEM FGEVGSLCNI PQPFTCRTAE LSQLLRISKT RLREIIEENR
490 500 510 520 530 540
EDSNILMNNL VQKLKLRESL PDMNQPDRRF LSKYELFHVP REAWLLKKSQ LHYTEHTSRD
550 560 570 580 590 600
SSNNTPVFGG DRYSRQLLGE ATRSSASENE NSSMTDKEEN HDEVHTNCEI KKRTEEHCIQ
610 620 630 640 650 660
INSEDSSSTY SQRTMNATVQ TGSPHKTEEN ITRRIPDEYY IKEANKRVTI HKYRHNSTVS
670 680 690 700 710
AAQNGKLIKL PTSLEELFKI GSQKFQGFHP RKVVSRDYAE IDDVSVIRDG DHLFLLEM