Q6J9G0
PR
Gene name |
STYK1 (NOK) |
Protein name |
Tyrosine-protein kinase STYK1 |
Names |
Novel oncogene with kinase domain, Protein PK-unique, Serine/threonine/tyrosine kinase 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:55359 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6J9G0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6J9G0-F1 | Predicted | AlphaFoldDB |
368 variants for Q6J9G0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs776855217 CA6447481 |
3 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA6447480 rs766525647 |
4 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs773219958 CA6447478 |
5 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6447479 rs148500176 |
5 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM129493 CA6447477 rs772165445 |
6 | M>I | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA383898787 rs1429623750 |
14 | D>E | No |
ClinGen gnomAD |
|
|
CA232891348 rs917866065 |
14 | D>N | No |
ClinGen Ensembl |
|
|
rs761901065 CA6447457 |
19 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs774167084 CA6447456 |
21 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs775483348 CA6447453 |
27 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1591682501 CA383898679 |
28 | I>V | No |
ClinGen Ensembl |
|
|
rs1213198117 CA383898669 |
29 | V>G | No |
ClinGen TOPMed |
|
|
CA6447451 rs139819909 |
29 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs139819909 CA383898673 |
29 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs866593907 CA232890837 |
30 | P>S | No |
ClinGen Ensembl |
|
|
rs780850321 CA383898660 |
31 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA6447450 rs780850321 |
31 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA232890807 rs997416875 |
36 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA6447449 rs756733556 |
36 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA6447446 rs755541966 |
39 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755541966 CA6447447 |
39 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383898606 rs1403584983 |
40 | L>F | No |
ClinGen gnomAD |
|
|
rs1014054235 CA232890776 |
40 | L>R | No |
ClinGen Ensembl |
|
|
rs1476941442 CA383898589 |
43 | V>F | No |
ClinGen TOPMed |
|
|
CA383898578 rs1591682421 |
45 | L>V | No |
ClinGen Ensembl |
|
|
rs1190528309 CA383898552 |
48 | F>L | No |
ClinGen TOPMed |
|
|
rs1158700479 CA383898554 |
48 | F>S | No |
ClinGen gnomAD |
|
|
rs756427676 CA6447443 |
49 | I>V | No |
ClinGen ExAC gnomAD |
|
|
COSM3416434 rs761803211 CA6447441 |
51 | E>* | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA6447440 rs761803211 |
51 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1432488992 CA383898499 |
56 | Q>P | No |
ClinGen gnomAD |
|
|
rs200788356 CA6447439 |
58 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6447438 rs200398907 |
58 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs200398907 CA383898483 |
58 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA383898478 rs775530218 |
59 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775530218 CA6447436 |
59 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383898477 rs1434837704 |
60 | G>R | No |
ClinGen TOPMed |
|
|
CA383898469 rs1208900513 |
61 | P>S | No |
ClinGen gnomAD |
|
|
rs776551281 CA6447413 |
64 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6447412 rs770613736 |
65 | A>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 67 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1460366860 CA383898073 |
67 | V>I | No |
ClinGen gnomAD |
|
|
rs140174760 CA6447410 |
68 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs140174760 CA6447411 |
68 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1169194446 CA383898051 |
69 | P>S | No |
ClinGen gnomAD |
|
|
rs1431387160 CA383898041 |
70 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
VAR_030766 rs6650202 RCV000947424 CA6447408 |
71 | R>G | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA232888476 rs544976107 |
72 | D>E | No |
ClinGen gnomAD |
|
|
CA6447405 rs746345937 |
72 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs141588195 CA6447406 |
72 | D>Y | No |
ClinGen ESP ExAC gnomAD |
|
|
CA383898009 rs1274528960 |
73 | L>V | No |
ClinGen gnomAD |
|
|
CA6447404 rs781657250 |
74 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA383897939 rs1344674098 |
78 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
CA383897941 rs1344674098 |
78 | G>E | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 79 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6447403 rs376952060 |
81 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1244268423 CA383897829 |
88 | K>N | No |
ClinGen gnomAD |
|
| TCGA novel | 89 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6447402 rs147503302 |
89 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA383897814 rs1315153750 |
90 | T>A | No |
ClinGen gnomAD |
|
|
rs373190195 CA6447401 |
90 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373190195 CA383897810 |
90 | T>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA383897805 rs1591680318 |
91 | S>P | No |
ClinGen Ensembl |
|
|
CA6447399 rs368958610 |
92 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA383897771 rs1591680301 |
94 | N>T | No |
ClinGen Ensembl |
|
|
rs765221937 CA6447398 |
95 | F>C | No |
ClinGen ExAC |
|
|
rs754996298 CA6447397 |
96 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6447396 rs556588635 |
98 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA383897729 rs1458063811 |
99 | T>A | No |
ClinGen gnomAD |
|
|
rs760410312 CA6447394 |
101 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs772862342 CA6447393 |
102 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs1192412796 CA383897694 |
103 | L>P | No |
ClinGen gnomAD |
|
|
CA6447390 rs773908327 |
104 | A>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 105 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768028100 CA6447389 |
106 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1357550955 CA383897650 |
108 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
COSM1358491 rs746426634 CA6447387 |
109 | P>L | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA383897626 rs149269676 |
110 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs747312882 CA6447384 |
110 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs149269676 CA6447385 |
110 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs142154340 CA232888360 |
111 | E>D | No |
ClinGen Ensembl |
|
|
CA232888357 rs148670088 |
112 | Q>E | No |
ClinGen Ensembl |
|
|
rs145049094 CA232888354 |
112 | Q>P | No |
ClinGen Ensembl |
|
|
CA383897559 rs1343601660 |
114 | S>F | No |
ClinGen gnomAD |
|
|
CA383897519 rs377592277 |
117 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6447383 rs377592277 |
117 | L>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA232888325 rs554544771 |
122 | S>R | No |
ClinGen 1000Genomes |
|
|
CA383897422 rs2290717 |
122 | S>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA383897430 rs1286685685 |
122 | S>T | No |
ClinGen gnomAD |
|
|
rs779093298 CA6447380 |
123 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs753832021 CA6447377 |
125 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs144759039 CA6447378 |
125 | C>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1591680090 CA383897379 |
125 | C>W | No |
ClinGen Ensembl |
|
|
CA383897368 rs766167537 |
127 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA6447376 rs766167537 |
127 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA383897360 rs1591680071 |
128 | I>L | No |
ClinGen Ensembl |
|
|
CA383897357 rs1452543943 |
128 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA6447374 rs750282683 |
129 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA6447373 rs761503840 |
130 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6447372 rs761503840 |
130 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747238411 CA383897320 |
130 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747238411 COSM3416433 CA6447371 |
130 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs763682376 CA6447370 |
131 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6447367 rs777198366 |
132 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777198366 CA6447368 |
132 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6447366 rs373597999 |
133 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA383897259 rs1233881068 |
135 | T>N | No |
ClinGen gnomAD |
|
|
rs775638353 CA232888208 |
135 | T>S | No |
ClinGen Ensembl |
|
|
rs773757873 CA6447364 |
136 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs747503076 CA6447365 |
136 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1433846911 CA383897216 |
137 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA6447362 rs748408554 |
138 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs772530382 CA6447363 |
138 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA383897150 rs1172437375 |
142 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA383897152 rs1400950635 |
142 | K>R | No |
ClinGen gnomAD |
|
|
CA232888167 rs868017706 |
143 | S>G | No |
ClinGen Ensembl |
|
|
rs1478651188 CA383897110 |
144 | V>A | No |
ClinGen gnomAD |
|
|
CA383897073 rs1187103882 |
146 | L>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA6447359 rs749262669 |
147 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1332063353 CA383897067 |
147 | K>R | No |
ClinGen gnomAD |
|
|
rs780180146 CA6447358 |
150 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA6447335 rs529409395 |
153 | A>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 155 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs953053267 CA232886871 |
159 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
CA383896846 rs999867422 |
160 | D>H | No |
ClinGen TOPMed |
|
|
CA232886867 rs999867422 |
160 | D>N | No |
ClinGen TOPMed |
|
|
CA383896823 rs1371501795 |
162 | L>S | No |
ClinGen gnomAD |
|
|
CA6447330 COSM934491 rs759063099 |
164 | R>* | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA6447329 rs552377763 |
164 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 165 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1442788063 CA383896756 |
168 | H>R | No |
ClinGen TOPMed |
|
|
CA383896743 rs1249719412 |
169 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA6447327 rs762380757 |
171 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs1483355413 CA383896718 |
172 | G>R | No |
ClinGen gnomAD |
|
|
CA383896683 rs1219074924 |
174 | H>Q | No |
ClinGen gnomAD |
|
|
rs1253656020 CA383896690 |
174 | H>Y | No |
ClinGen gnomAD |
|
|
CA383896662 rs1591678443 |
176 | N>T | No |
ClinGen Ensembl |
|
|
CA6447326 rs774640032 |
177 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs540861135 CA6447324 |
179 | Q>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6447323 rs775651419 |
180 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1287178951 CA383896598 |
182 | G>D | No |
ClinGen gnomAD |
|
|
rs375822208 CA6447322 |
184 | C>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA383896581 rs1170383043 |
184 | C>R | No |
ClinGen Ensembl |
|
|
rs533199675 CA232886770 |
185 | T>A | No |
ClinGen Ensembl |
|
|
CA6447321 rs745881619 |
185 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs1434746368 CA383896550 |
186 | E>D | No |
ClinGen gnomAD |
|
|
rs267603285 CA232886761 |
186 | E>K | No |
ClinGen gnomAD |
|
|
rs770911651 CA6447319 |
187 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs776687323 CA6447320 |
187 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs1463222331 CA383896535 |
188 | L>V | No |
ClinGen gnomAD |
|
|
CA6447318 rs746941428 |
189 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA232886733 rs963187265 |
190 | L>F | No |
ClinGen gnomAD |
|
|
CA383896518 rs963187265 |
190 | L>V | No |
ClinGen gnomAD |
|
| TCGA novel | 192 | M>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6447315 rs371894989 |
192 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1254323830 CA383896476 |
193 | V>G | No |
ClinGen Ensembl |
|
|
CA6447314 rs778654365 |
195 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA383896442 rs1208783485 |
196 | D>E | No |
ClinGen gnomAD |
|
|
rs1267142700 CA383896446 |
196 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
CA383896449 rs1463290424 |
196 | D>N | No |
ClinGen gnomAD |
|
|
rs1267142700 CA383896444 |
196 | D>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 197 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA383896413 rs1474042038 |
199 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA383896402 rs1309779000 |
200 | G>A | No |
ClinGen gnomAD |
|
|
CA383896403 rs1309779000 |
200 | G>E | No |
ClinGen gnomAD |
|
|
COSM251156 rs1217980969 CA383896400 |
201 | D>N | liver [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1367270675 CA383896381 |
202 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
CA383896384 rs1367270675 |
202 | L>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs3759259 CA383896367 |
204 | S>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs3759259 VAR_022245 CA6447309 |
204 | S>G | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs3759259 CA383896368 |
204 | S>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1591678191 CA383896356 |
205 | F>L | No |
ClinGen Ensembl |
|
|
CA6447308 rs764398352 |
206 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs544882621 CA6447307 |
208 | T>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1347109435 CA383896311 |
209 | C>R | No |
ClinGen gnomAD |
|
|
rs556130470 CA6447305 |
210 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs34981955 CA6447306 VAR_041841 |
210 | R>W | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA6447303 COSM934490 rs200579192 |
211 | R>Q | endometrium Variant assessed as Somatic; 0.0002776 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs759739907 CA6447304 |
211 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1013414861 CA232885454 |
212 | D>G | No |
ClinGen Ensembl |
|
|
rs1314572170 CA383895844 |
214 | M>V | No |
ClinGen gnomAD |
|
|
CA232885440 rs113621799 |
219 | L>P | No |
ClinGen Ensembl |
|
|
CA6447284 rs759793001 |
221 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA232885412 rs752613514 |
225 | E>D | No |
ClinGen Ensembl |
|
|
CA383895726 rs1366329841 |
225 | E>G | No |
ClinGen gnomAD |
|
|
rs766388729 CA6447282 |
228 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs760747165 CA6447281 |
229 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1565560151 CA383895691 |
229 | Y>H | No |
ClinGen Ensembl |
|
| TCGA novel | 230 | H>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA383895676 rs1419399667 |
230 | H>Y | No |
ClinGen gnomAD |
|
|
CA6447279 rs151245563 |
231 | I>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs773024003 CA6447280 |
231 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA6447277 rs370772078 |
232 | G>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6447276 rs370772078 |
232 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6447275 rs548327379 |
233 | K>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1263893784 CA383895628 |
234 | Q>H | No |
ClinGen gnomAD |
|
|
CA6447274 rs779708848 |
234 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
CA6447272 rs745449950 |
235 | V>D | No |
ClinGen ExAC gnomAD |
|
|
rs769201420 CA6447273 |
235 | V>F | No |
ClinGen ExAC gnomAD |
|
|
rs780553680 CA6447271 |
236 | L>H | No |
ClinGen ExAC gnomAD |
|
|
CA6447270 VAR_041842 rs55877878 |
237 | L>S | No |
ClinGen UniProt ExAC TOPMed dbSNP gnomAD |
|
|
rs753170900 CA6447269 |
238 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM3687921 rs753170900 CA232885328 |
238 | A>V | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA6447266 rs754069322 |
239 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs767669011 CA6447244 |
240 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751556780 CA6447242 |
243 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751556780 CA6447243 |
243 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6447240 rs762970339 |
246 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs796206194 CA232883095 |
248 | F>Y | No |
ClinGen Ensembl |
|
|
CA6447237 rs759262803 |
251 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs868657039 CA383895331 CA232883079 |
252 | V>L | No |
ClinGen TOPMed |
|
|
CA383895332 rs868657039 |
252 | V>M | No |
ClinGen TOPMed |
|
|
CA383895313 rs776096075 |
255 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1178131009 CA383895303 |
256 | N>S | No |
ClinGen TOPMed |
|
|
CA383895283 rs1255367507 |
259 | M>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs147702530 CA6447234 |
260 | Q>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772701157 CA6447233 |
262 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs144579142 CA383895231 |
266 | K>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1319765447 CA383895199 |
271 | G>A | No |
ClinGen gnomAD |
|
| TCGA novel | 271 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1365266966 CA383895203 |
271 | G>S | No |
ClinGen gnomAD |
|
| TCGA novel | 271 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs749741594 CA6447231 |
272 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA383895188 rs1172518849 |
273 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA232883043 rs1001028785 |
274 | Y>C | No |
ClinGen TOPMed |
|
|
CA232883038 rs944038368 |
275 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA383895172 rs1397344727 |
276 | V>I | No |
ClinGen gnomAD |
|
|
rs1298195687 CA383895158 |
278 | T>A | No |
ClinGen gnomAD |
|
|
rs756396756 CA6447229 |
278 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA383895154 rs140055345 |
279 | R>* | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs140055345 CA232883030 |
279 | R>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA TOPMed gnomAD |
|
CA6447228 rs147511596 |
279 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6447227 rs781509569 |
280 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs757418361 CA6447226 |
281 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1255309683 CA383895144 |
281 | A>S | No |
ClinGen gnomAD |
|
|
CA383895140 rs1349770512 |
282 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 284 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6447225 rs375218202 |
285 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1227174520 CA383895116 |
286 | Q>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA383895108 rs1203862824 |
287 | T>A | No |
ClinGen TOPMed |
|
|
rs1362904499 CA383895101 |
288 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1362904499 CA383895102 |
288 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA6447224 rs764246183 |
289 | P>T | No |
ClinGen ExAC |
|
|
rs372543976 CA232883016 |
290 | L>F | No |
ClinGen ESP gnomAD |
|
|
CA6447223 rs758401545 |
292 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA232883009 rs878920690 |
294 | A>S | No |
ClinGen Ensembl |
|
|
rs752534616 CA6447222 |
294 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA232882987 rs371881097 |
295 | P>A | No |
ClinGen ESP TOPMed |
|
|
CA383895058 rs1415998813 |
295 | P>L | No |
ClinGen gnomAD |
|
|
rs779416838 CA383895053 |
296 | E>A | No |
ClinGen gnomAD |
|
|
CA232882982 rs779416838 |
296 | E>G | No |
ClinGen gnomAD |
|
|
rs866925878 CA232882983 |
296 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA6447219 COSM327527 rs368292071 |
297 | R>Q | Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs563102176 CA6447220 |
297 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA232882963 rs543218286 |
298 | L>H | No |
ClinGen 1000Genomes gnomAD |
|
|
rs543218286 CA383895043 |
298 | L>P | No |
ClinGen 1000Genomes gnomAD |
|
|
CA6447218 rs766083083 |
300 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1368032964 CA383895023 |
302 | P>A | No |
ClinGen gnomAD |
|
|
CA6447217 rs760304108 |
303 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs200525861 CA383895005 |
305 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1170474621 CA383895003 |
305 | I>N | No |
ClinGen TOPMed |
|
|
rs200525861 CA6447216 |
305 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383894979 rs1438197223 |
308 | D>E | No |
ClinGen gnomAD |
|
|
rs1565558443 CA383894985 |
308 | D>N | No |
ClinGen Ensembl |
|
|
CA6447214 rs749836195 |
309 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA232882042 rs866533819 |
311 | S>F | No |
ClinGen Ensembl |
|
|
COSM1358488 rs781319343 CA6447202 |
313 | G>E | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1450722323 CA383894930 |
314 | I>T | No |
ClinGen gnomAD |
|
|
CA383894912 rs1326471882 |
317 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
CA6447174 rs761049908 |
324 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA383894853 rs1462021404 |
324 | A>V | No |
ClinGen TOPMed |
|
|
rs1447330404 CA383894850 |
325 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA6447172 rs149841464 |
326 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6447173 rs773702820 |
326 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383894832 rs1244272001 |
328 | P>T | No |
ClinGen gnomAD |
|
|
rs61730096 CA232881593 |
330 | V>F | No |
ClinGen gnomAD |
|
|
rs778902636 CA383894811 |
331 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778902636 CA6447170 |
331 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383894799 rs1281553972 |
333 | T>I | No |
ClinGen gnomAD |
|
|
CA6447169 rs140032147 |
334 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6447168 rs369987404 |
334 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA383894785 rs1329241062 |
336 | L>I | No |
ClinGen TOPMed |
|
|
CA383894782 rs1295151216 |
336 | L>P | No |
ClinGen gnomAD |
|
|
CA383894780 rs1375969540 |
337 | E>Q | No |
ClinGen TOPMed |
|
|
rs150718886 CA232881571 |
339 | L>V | No |
ClinGen ESP |
|
| TCGA novel | 341 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 344 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755908542 CA6447166 |
345 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383894721 rs1280837835 |
345 | M>V | No |
ClinGen TOPMed |
|
| TCGA novel | 347 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1470405876 CA383894695 |
348 | P>R | No |
ClinGen gnomAD |
|
|
rs1301004725 CA383894690 |
349 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA383894687 rs1414148843 |
349 | S>R | No |
ClinGen gnomAD |
|
|
rs141167107 CA6447165 |
350 | S>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756910970 CA6447163 |
351 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383894666 rs1372086742 |
352 | T>K | No |
ClinGen gnomAD |
|
|
rs751182051 CA383894661 |
353 | H>L | No |
ClinGen ExAC gnomAD |
|
|
CA6447162 COSM467725 rs751182051 |
353 | H>R | kidney [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs376420102 CA232881548 |
354 | T>P | No |
ClinGen ESP TOPMed |
|
|
CA383894654 rs1429770037 |
354 | T>S | No |
ClinGen gnomAD |
|
|
rs763531902 CA6447161 |
355 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA383894420 rs1335554542 |
356 | Y>H | No |
ClinGen gnomAD |
|
|
CA383894413 rs1241134878 |
357 | S>G | No |
ClinGen TOPMed |
|
|
CA6447142 rs200052894 |
358 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1226561239 CA383894395 |
359 | M>T | No |
ClinGen gnomAD |
|
|
CA6447141 rs764816144 |
360 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA383894383 rs1307491868 |
361 | S>P | No |
ClinGen gnomAD |
|
|
TCGA novel CA6447140 rs756724580 |
363 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen ExAC TOPMed gnomAD |
|
rs750905388 CA6447139 |
364 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA232880723 COSM180697 rs375423751 |
364 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6447138 rs375423751 |
364 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs537296580 CA6447137 COSM934489 |
366 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs537296580 CA383894348 |
366 | R>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
COSM129492 CA6447136 rs189204525 |
366 | R>H | upper_aerodigestive_tract Variant assessed as Somatic; 4.625e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs764368001 CA6447135 |
368 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1591671341 CA383894329 |
369 | D>A | No |
ClinGen Ensembl |
|
|
CA383894332 rs1452314363 |
369 | D>N | No |
ClinGen gnomAD |
|
|
CA6447133 rs775598308 |
370 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs554694983 COSM1945323 CA6447132 |
370 | R>H | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA232880695 rs996563648 |
371 | P>L | No |
ClinGen TOPMed |
|
|
CA6447131 rs745814636 |
371 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA383894320 rs745814636 |
371 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs1193313177 CA383894314 |
372 | S>A | No |
ClinGen TOPMed gnomAD |
|
|
CA6447130 rs776571964 |
372 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA6447129 rs368633325 |
373 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1237196199 CA383894294 |
375 | E>D | No |
ClinGen TOPMed |
|
|
CA6447128 rs746888308 |
375 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs750078425 COSM1227963 CA6447127 |
377 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs758169281 CA6447126 |
377 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs138533962 CA6447124 |
379 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs34638573 CA6447122 VAR_041843 |
379 | R>H | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs34638573 CA6447123 |
379 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6447125 rs138533962 |
379 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 381 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 381 | E>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA383894260 rs1302228287 |
382 | A>P | No |
ClinGen gnomAD |
|
|
CA232880646 rs765002535 |
383 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA232880638 rs543183600 |
384 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA383894240 rs1372508459 |
385 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1372508459 CA383894241 |
385 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1317912567 CA383894231 |
386 | T>I | No |
ClinGen gnomAD |
|
|
rs757703854 CA6447120 |
387 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs144640797 CA6447119 |
388 | D>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA383894209 rs763203243 |
390 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763203243 CA6447117 |
390 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA232880615 rs886903856 |
391 | A>V | No |
ClinGen TOPMed |
|
|
CA232880613 rs142457407 |
392 | V>L | No |
ClinGen ESP TOPMed |
|
| TCGA novel | 393 | L>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6447115 rs765311647 |
394 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1191050761 CA383894175 |
395 | V>E | No |
ClinGen gnomAD |
|
| VAR_041844 | 395 | V>I | a glioblastoma multiforme sample; somatic mutation [UniProt] | No | UniProt |
|
CA6447113 rs201489196 |
396 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs967812609 CA232880595 |
398 | L>F | No |
ClinGen gnomAD |
|
|
CA232880602 rs1001809553 |
398 | L>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA6447111 rs770955470 |
399 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA6447110 rs55766125 VAR_041845 CA232880582 |
400 | V>L | No |
ClinGen ExAC gnomAD UniProt dbSNP |
|
|
CA232880573 rs1011755586 |
401 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA383894146 rs1349544294 |
401 | P>T | No |
ClinGen gnomAD |
|
| TCGA novel | 402 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768420578 CA6447106 |
409 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6447105 rs747827791 |
411 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs778653950 CA6447104 |
412 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs891921452 CA383894067 |
413 | E>D | No |
ClinGen gnomAD |
|
|
rs1281201618 CA383894073 |
413 | E>K | No |
ClinGen TOPMed |
|
|
CA6447103 rs768060438 |
415 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs748899539 CA6447102 |
418 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs1565556352 CA383894015 |
420 | S>R | No |
ClinGen Ensembl |
|
|
CA383894005 rs1224085993 |
421 | M>I | No |
ClinGen TOPMed |
No associated diseases with Q6J9G0
4 regional properties for Q6J9G0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 33 - 40 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 222 - 235 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 359 - 373 | IPR018181-3 |
| domain | Endoplasmic reticulum chaperone BIP, nucleotide-binding domain | 28 - 403 | IPR042050 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
94 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P43405 | SYK | Tyrosine-protein kinase SYK | Homo sapiens (Human) | EV |
| P43403 | ZAP70 | Tyrosine-protein kinase ZAP-70 | Homo sapiens (Human) | EV |
| Q13882 | PTK6 | Protein-tyrosine kinase 6 | Homo sapiens (Human) | EV |
| P09769 | FGR | Tyrosine-protein kinase Fgr | Homo sapiens (Human) | SS |
| P07948 | LYN | Tyrosine-protein kinase Lyn | Homo sapiens (Human) | SS |
| P06241 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens (Human) | SS |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (Human) | EV |
| P06239 | LCK | Tyrosine-protein kinase Lck | Homo sapiens (Human) | EV |
| P51451 | BLK | Tyrosine-protein kinase Blk | Homo sapiens (Human) | SS |
| P08631 | HCK | Tyrosine-protein kinase HCK | Homo sapiens (Human) | EV |
| P07947 | YES1 | Tyrosine-protein kinase Yes | Homo sapiens (Human) | SS |
| P42685 | FRK | Tyrosine-protein kinase FRK | Homo sapiens (Human) | EV |
| Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Homo sapiens (Human) | EV |
| Q06187 | BTK | Tyrosine-protein kinase BTK | Homo sapiens (Human) | EV |
| P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (Human) | SS |
| P42680 | TEC | Tyrosine-protein kinase Tec | Homo sapiens (Human) | SS |
| P42679 | MATK | Megakaryocyte-associated tyrosine-protein kinase | Homo sapiens (Human) | SS |
| P41240 | CSK | Tyrosine-protein kinase CSK | Homo sapiens (Human) | SS |
| Q14289 | PTK2B | Protein-tyrosine kinase 2-beta | Homo sapiens (Human) | PR |
| Q05397 | PTK2 | Focal adhesion kinase 1 | Homo sapiens (Human) | EV |
| Q13470 | TNK1 | Non-receptor tyrosine-protein kinase TNK1 | Homo sapiens (Human) | PR |
| Q07912 | TNK2 | Activated CDC42 kinase 1 | Homo sapiens (Human) | EV |
| P16591 | FER | Tyrosine-protein kinase Fer | Homo sapiens (Human) | PR |
| P42684 | ABL2 | Tyrosine-protein kinase ABL2 | Homo sapiens (Human) | SS |
| P00519 | ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens (Human) | EV |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGMTRMLLEC | SLSDKLCVIQ | EKQYEVIIVP | TLLVTIFLIL | LGVILWLFIR | EQRTQQQRSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PQGIAPVPPP | RDLSWEAGHG | GNVALPLKET | SVENFLGATT | PALAKLQVPR | EQLSEVLEQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CSGSCGPIFR | ANMNTGDPSK | PKSVILKALK | EPAGLHEVQD | FLGRIQFHQY | LGKHKNLVQL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGCCTEKLPL | YMVLEDVAQG | DLLSFLWTCR | RDVMTMDGLL | YDLTEKQVYH | IGKQVLLALE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLQEKHLFHG | DVAARNILMQ | SDLTAKLCGL | GLAYEVYTRG | AISSTQTIPL | KWLAPERLLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RPASIRADVW | SFGILLYEMV | TLGAPPYPEV | PPTSILEHLQ | RRKIMKRPSS | CTHTMYSIMK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SCWRWREADR | PSPRELRLRL | EAAIKTADDE | AVLQVPELVV | PELYAAVAGI | RVESLFYNYS |
| ML |