Q6IMM1
Gene name |
DNAJC27 (RBJ) |
Protein name |
DnaJ homolog subfamily C member 27 |
Names |
Rab and DnaJ domain-containing protein |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:402783 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6IMM1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6IMM1-F1 | Predicted | AlphaFoldDB |
7 variants for Q6IMM1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs314062299 | 32 | I>F | No | Ensembl | |
| rs739652559 | 95 | V>G | No | Ensembl | |
| rs737204507 | 132 | C>W | No | Ensembl | |
| rs734993611 | 179 | Y>S | No | Ensembl | |
| rs732531089 | 222 | L>R | No | Ensembl | |
| rs1058764476 | 250 | V>A | No | Ensembl | |
| rs312593001 | 261 | V>G | No | Ensembl |
No associated diseases with Q6IMM1
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| regulation of MAPK export from nucleus | Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90965 | RAB2A | Ras-related protein Rab-2A | Gallus gallus (Chicken) | PR |
| Q1KME6 | RAB6A | Ras-related protein Rab-6A | Gallus gallus (Chicken) | PR |
| Q5ZLG1 | RAB18 | Ras-related protein Rab-18 | Gallus gallus (Chicken) | PR |
| Q5ZKR4 | RABL3 | Rab-like protein 3 | Gallus gallus (Chicken) | PR |
| P61019 | RAB2A | Ras-related protein Rab-2A | Homo sapiens (Human) | PR |
| Q8WUD1 | RAB2B | Ras-related protein Rab-2B | Homo sapiens (Human) | PR |
| P53994 | Rab2a | Ras-related protein Rab-2A | Mus musculus (Mouse) | PR |
| Q8CFP6 | Dnajc27 | DnaJ homolog subfamily C member 27 | Mus musculus (Mouse) | PR |
| P05712 | Rab2a | Ras-related protein Rab-2A | Rattus norvegicus (Rat) | PR |
| Q6IML7 | Dnajc27 | DnaJ homolog subfamily C member 27 | Rattus norvegicus (Rat) | PR |
| Q6IMK3 | dnajc27 | DnaJ homolog subfamily C member 27 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEANAPKRKE | ARKSLRIKVI | SMGNAEVGKS | CIIKRYCEKR | FVPKYLATIG | IDYGVTKVQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDREIKVNIF | DMAGHPFFYE | VRNEFYKDTQ | GVILVYDVGQ | KESFDALDAW | LAEMKQELGP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HGNMDNIVFV | VCANKIDCTK | HRSVDESEGR | LWAESRGFLY | FETSAQTGEG | INEMFQTFYS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AIIDLCDNGG | KRPPSSMGVG | FTKEQADAIR | RIRNSKDSWD | MLGVKPGATR | DEVNKAYRKL |
| 250 | 260 | 270 | |||
| AVLLHPDKCV | APGSEDAFKA | VVNARTALLK | NIK |