Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6IMK3

Entry ID Method Resolution Chain Position Source
AF-Q6IMK3-F1 Predicted AlphaFoldDB

No variants for Q6IMK3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6IMK3

No associated diseases with Q6IMK3

2 regional properties for Q6IMK3

Type Name Position InterPro Accession
domain DnaJ domain 216 - 273 IPR001623
domain Small GTP-binding protein domain 17 - 176 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90965 RAB2A Ras-related protein Rab-2A Gallus gallus (Chicken) PR
Q6IMM1 DNAJC27 DnaJ homolog subfamily C member 27 Gallus gallus (Chicken) PR
P61019 RAB2A Ras-related protein Rab-2A Homo sapiens (Human) PR
Q8WUD1 RAB2B Ras-related protein Rab-2B Homo sapiens (Human) PR
P53994 Rab2a Ras-related protein Rab-2A Mus musculus (Mouse) PR
Q8CFP6 Dnajc27 DnaJ homolog subfamily C member 27 Mus musculus (Mouse) PR
P05712 Rab2a Ras-related protein Rab-2A Rattus norvegicus (Rat) PR
Q6IML7 Dnajc27 DnaJ homolog subfamily C member 27 Rattus norvegicus (Rat) PR
Q6DHC1 rab18b Ras-related protein Rab-18-B Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6TNS7 rabl3 Rab-like protein 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDTNVQKRRE NKKSLRVKVI SLGNAEVGKS CIIKRYCEKR FVPKYLATIG IDYGVTKVQV
70 80 90 100 110 120
RDREIKVNIF DMAGHPFFYE VRNEFYKDSQ GVILVYDVGL RESFDALDSW LTEMKQEMGS
130 140 150 160 170 180
QANMENIIFV VCANKVDLTK RRVVDESEGR LWAESRGFHY FETSAQSGEG INEMFQSFFS
190 200 210 220 230 240
SITDMCENGG KRPTPEVSVG FTKEQADTIR RIRNSKDSWD MLGVKPGATR EEVNKAYRKL
250 260 270
AVLLHPDKCV APGSEDAFKA VVNARTSLLK NIK