Q6IDD9

SS
Gene name
Sarm (Ect4, CG43119)
Protein name
NAD
Names
+ hydrolase sarm1 , NADase sarm1 , EC 3.2.2.6 , Sterile alpha and TIR motif-containing protein 1 , Tir-1 homolog
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG43119
EC number
3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

Sterile alpha and Toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) regulates axon degeneration, functioning as a key player in the cellular processes involved in neurodegenerative diseases and nerve injury. The physical interaction between the autoinhibitory Armadillo/HEAT motif (ARM) and catalytic Toll/interleukin-1 receptor (TIR) domains blocks the NAD hydrolase activity of SARM1. The autoinhibited TIR domain is activated upon axon injury, activating its NAD+ hydrolase activity and enabling TIR-dependent neuronal destruction.

Autoinhibitory domains (AIDs)

332-687 (ARM domain) SS

Target domain

837-981 (TIR domain)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q6IDD9

Entry ID Method Resolution Chain Position Source
7LCY X-ray 335 A A/B/C 314-678 PDB
7LCZ X-ray 165 A A/B 370-678 PDB
7M6K X-ray 169 A A/B 369-678 PDB
7RTC X-ray 331 A A/B/C 315-678 PDB
AF-Q6IDD9-F1 Predicted AlphaFoldDB

No variants for Q6IDD9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6IDD9

No associated diseases with Q6IDD9

3 regional properties for Q6IDD9

Type Name Position InterPro Accession
domain Toll/interleukin-1 receptor homology (TIR) domain 837 - 981 IPR000157
domain Sterile alpha motif domain 687 - 754 IPR001660-1
domain Sterile alpha motif domain 757 - 826 IPR001660-2

Functions

Description
EC Number 3.2.2.6 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • Cytoplasm
  • Cell projection, axon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

4 GO annotations of molecular function

Name Definition
NAD+ nucleosidase activity Catalysis of the reaction
NAD+ nucleotidase, cyclic ADP-ribose generating Catalysis of the reaction
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
STAT family protein binding Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.

7 GO annotations of biological process

Name Definition
antiviral innate immune response A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
NAD catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH.
negative regulation of MyD88-independent toll-like receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway.
positive regulation of receptor signaling pathway via STAT Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT.
response to axon injury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6SZW1 SARM1 NAD hydrolase SARM1 hydrolase SARM1) Homo sapiens (Human) EV
Q6PDS3 Sarm1 NAD Mus musculus (Mouse) SS
I3L5V6 SARM1 NAD Sus scrofa (Pig) SS
D3ZUM2 Sarm1 NAD Rattus norvegicus (Rat) SS
F1QWA8 sarm1 NAD Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MKAAEIKRDL TNIQKSMSEI NDLAKERITG GPGSISTTSA SAITAPSTMS QTTTSRLAPK
70 80 90 100 110 120
LTSAHPSIDD LRGLSRQDKI TQLQKKIRAS FENLVDHDDS NVIVTLPDDD DCPHNHFGSG
130 140 150 160 170 180
LNLTHPTAAQ LSASGLSGSS KTIDTIKFQE KSMKTESKTK VVTDGFSSEQ ATSNSAEMKR
190 200 210 220 230 240
LQAGDIDYQE SKGASAMRNR LEVDGVKTEE NAAVIKEALS LRTGDITQQA SNNVAASSIT
250 260 270 280 290 300
VQSENFSADK KAISQSQQSQ TMTSNGIISQ EKHVSSASQA NYSMSHKGVS STGSSMITSS
310 320 330 340 350 360
SQMSAMNGQM LKLADLKLDD LKSLTAGSGQ QEIEQTINKY SNMLTSIVSS LQEDERGGSA
370 380 390 400 410 420
ITVHDVGGKK SQYLEKINEV IRRAWAVPTH GHELGYSLCN SLRQSGGLDL LMKNCVKPDL
430 440 450 460 470 480
QFSSAQLLEQ CLTTENRKHV VDNGLDKVVN VACVCTKNSN MEHSRVGTGI LEHLFKHSEG
490 500 510 520 530 540
TCSDVIRLGG LDAVLFECRT SDLETLRHCA SALANLSLYG GAENQEEMIL RKVPMWLFPL
550 560 570 580 590 600
AFHNDDNIKY YACLAIAVLV ANKEIEAEVL KSGCLDLVEP FVTSHDPSAF ARSNLAHAHG
610 620 630 640 650 660
QSKHWLKRLV PVLSSNREEA RNLAAFHFCM EAGIKREQGN TDIFREINAI EALKNVASCP
670 680 690 700 710 720
NAIASKFAAQ ALRLIGETVP HKLSQQVPLW SVEDVQEWVK QIGFNDYIDK FNESQVDGDL
730 740 750 760 770 780
LLKLNQDNLR ADIGIGNGIL LKRFERELQN LKRMADYSSK DTAKMHQFLS EIGTDYCTYT
790 800 810 820 830 840
YAMLNAGIDK CALPHVNEDM LMTECGIHNS IHRLRILNAV KNLENSLPSS SEENMAKTLD
850 860 870 880 890 900
VFVSYRRSNG SQLASLLKVH LQLRGFSVFI DVERLEAGKF DNGLLNSIRQ AKNFVLVLTP
910 920 930 940 950 960
DALHRCINDE DCKDWVHREI VAALNSNCNI IPIIDQQFDW PEVERLPEDM RSVAHFNGVN
970 980 990 1000 1010 1020
WIHDYQDACI DKLERFLRGE KNIDRIAAMV PGTPGSVSYQ RMHSNDSDYQ SGGAGAGSGA
1030 1040 1050 1060 1070 1080
GTGGGGGGGV TGSVVDGLMV AANGSGQANH QANRYRQSPS PARQRGSTSQ LSGYSRAPSK
1090 1100 1110 1120 1130 1140
RSQILTPYRT QQAALLHKTG AGSASMQNMM PLAYLPPRRS SAAGLGHGSG SGMGSGYRSH
1150 1160 1170 1180 1190 1200
SVDGLLDQAG STPEQRIAAA AAKVTAGSTA LTNASSTSTL QPEEEVTDAA LNDSVTRRDK
1210 1220 1230 1240 1250 1260
HTLSPPGNVQ QHRKSRSLDH ILSKQTLAEL LPPSSELADG TQSMQNLAIP MTPQPQRRDT
1270 1280 1290 1300 1310 1320
SSSSKSPTPE RPPQPAMERV RERQSPEGVS ATESEREDQP EECLRHGNQQ RASASVHRGA
1330 1340 1350
SLTSNKTSNS SLGSNFSAGG NNKTIFNRTM KKVRSLIKKP