Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6HA09

Entry ID Method Resolution Chain Position Source
AF-Q6HA09-F1 Predicted AlphaFoldDB

34 variants for Q6HA09

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388588460 29 R>G No EVA
rs3388582993 76 G>R No EVA
rs3388592222 82 S>C No EVA
rs27416839 115 L>P No EVA
rs27416838 118 R>Q No EVA
rs3388593001 129 R>H No EVA
rs3388585622 157 V>M No EVA
rs3388588456 160 S>T No EVA
rs220060998 170 P>L No EVA
rs240326213 175 K>R No EVA
rs226010778 186 H>Q No EVA
rs3392047625 188 L>R No EVA
rs3388583183 228 V>I No EVA
rs3388594580 248 Q>P No EVA
rs3388582916 265 W>R No EVA
rs27416801 283 R>Q No EVA
rs49060460 300 S>R No EVA
rs3388583003 307 I>L No EVA
rs52026487 309 R>H No EVA
rs52026487 309 R>P No EVA
rs256440530 328 G>S No EVA
rs215945398 332 G>V No EVA
rs27416780 341 N>D No EVA
rs3391905925 357 G>* No EVA
rs27416779 368 D>A No EVA
rs3388587495 374 P>A No EVA
rs230364181 377 G>R No EVA
rs27416778 385 Q>K No EVA
rs3388589947 386 F>Y No EVA
rs3388588474 387 Q>R No EVA
rs3388591525 391 A>S No EVA
rs51753123 418 P>L No EVA
rs3392178490 423 C>W No EVA
rs261198974 424 A>V No EVA

No associated diseases with Q6HA09

2 regional properties for Q6HA09

Type Name Position InterPro Accession
domain Peptidase M12A 85 - 282 IPR001506
domain Peptidase, metallopeptidase 90 - 234 IPR006026

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Cytoplasmic vesicle, secretory vesicle, Cortical granule
  • Probably exocytosed from cortical granules during post-fertilization
  • Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3
  • Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization
  • Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages
  • Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cortical granule A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
aspartic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
glutamic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
negative regulation of binding of sperm to zona pellucida Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida.
positive regulation of protein processing Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.
prevention of polyspermy The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9DER7 TLL1 Tolloid-like protein 1 Gallus gallus (Chicken) PR
P25723 tld Dorsal-ventral patterning protein tolloid Drosophila melanogaster (Fruit fly) PR
O43897 TLL1 Tolloid-like protein 1 Homo sapiens (Human) PR
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Homo sapiens (Human) PR
P13497 BMP1 Bone morphogenetic protein 1 Homo sapiens (Human) PR
Q9Y6L7 TLL2 Tolloid-like protein 2 Homo sapiens (Human) PR
O08859 Tnfaip6 Tumor necrosis factor-inducible gene 6 protein Mus musculus (Mouse) PR
P98063 Bmp1 Bone morphogenetic protein 1 Mus musculus (Mouse) PR
Q9WVM6 Tll2 Tolloid-like protein 2 Mus musculus (Mouse) PR
Q62381 Tll1 Tolloid-like protein 1 Mus musculus (Mouse) PR
Q20176 nas-39 Zinc metalloproteinase nas-39 Caenorhabditis elegans PR
Q21252 nas-3 Zinc metalloproteinase nas-3 Caenorhabditis elegans PR
O62243 nas-1 Zinc metalloproteinase nas-1 Caenorhabditis elegans PR
Q18439 nas-8 Zinc metalloproteinase nas-8 Caenorhabditis elegans PR
Q20942 nas-38 Zinc metalloproteinase nas-38 Caenorhabditis elegans PR
Q9U3S9 nas-6 Zinc metalloproteinase nas-6 Caenorhabditis elegans PR
P55113 nas-7 Zinc metalloproteinase nas-7 Caenorhabditis elegans PR
P55112 nas-4 Zinc metalloproteinase nas-4 Caenorhabditis elegans PR
Q22398 nas-22 Zinc metalloproteinase nas-22 Caenorhabditis elegans PR
P55115 nas-15 Zinc metalloproteinase nas-15 Caenorhabditis elegans PR
O57460 tll1 Dorsal-ventral patterning tolloid-like protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGIMGSLWPW ILTMLSLLGL SMGAPSASRC SGVCSTSVPE GFTPEGSPVF QDKDIPAINQ
70 80 90 100 110 120
GLISEETPES SFLVEGDIIR PSPFRLLSVT NNKWPKGVGG FVEIPFLLSR KYDELSRRVI
130 140 150 160 170 180
MDAFAEFERF TCIRFVAYHG QRDFVSILPM AGCFSGVGRS GGMQVVSLAP TCLRKGRGIV
190 200 210 220 230 240
LHELMHVLGF WHEHSRADRD RYIQVNWNEI LPGFEINFIK SRSTNMLVPY DYSSVMHYGR
250 260 270 280 290 300
FAFSWRGQPT IIPLWTSSVH IGQRWNLSTS DITRVCRLYN CSRSVPDSHG RGFEAQSDGS
310 320 330 340 350 360
SLTPASISRL QRLLEALSEE SGSSAPSGSR TGGQSIAGLG NSQQGWEHPP QSTFSVGALA
370 380 390 400 410 420
RPPQMLADAS KSGPGAGADS LSLEQFQLAQ APTVPLALFP EARDKPAPIQ DAFERLAPLP
430
GGCAPGSHIR EVPRD