Q6HA09
Gene name |
Astl |
Protein name |
Astacin-like metalloendopeptidase |
Names |
Oocyte astacin, Ovastacin, Sperm acrosomal SLLP1-binding protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:215095 |
EC number |
|
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure

Activated structure

1 structures for Q6HA09
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q6HA09-F1 | Predicted | AlphaFoldDB |
34 variants for Q6HA09
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
rs3388588460 | 29 | R>G | No | EVA | |
rs3388582993 | 76 | G>R | No | EVA | |
rs3388592222 | 82 | S>C | No | EVA | |
rs27416839 | 115 | L>P | No | EVA | |
rs27416838 | 118 | R>Q | No | EVA | |
rs3388593001 | 129 | R>H | No | EVA | |
rs3388585622 | 157 | V>M | No | EVA | |
rs3388588456 | 160 | S>T | No | EVA | |
rs220060998 | 170 | P>L | No | EVA | |
rs240326213 | 175 | K>R | No | EVA | |
rs226010778 | 186 | H>Q | No | EVA | |
rs3392047625 | 188 | L>R | No | EVA | |
rs3388583183 | 228 | V>I | No | EVA | |
rs3388594580 | 248 | Q>P | No | EVA | |
rs3388582916 | 265 | W>R | No | EVA | |
rs27416801 | 283 | R>Q | No | EVA | |
rs49060460 | 300 | S>R | No | EVA | |
rs3388583003 | 307 | I>L | No | EVA | |
rs52026487 | 309 | R>H | No | EVA | |
rs52026487 | 309 | R>P | No | EVA | |
rs256440530 | 328 | G>S | No | EVA | |
rs215945398 | 332 | G>V | No | EVA | |
rs27416780 | 341 | N>D | No | EVA | |
rs3391905925 | 357 | G>* | No | EVA | |
rs27416779 | 368 | D>A | No | EVA | |
rs3388587495 | 374 | P>A | No | EVA | |
rs230364181 | 377 | G>R | No | EVA | |
rs27416778 | 385 | Q>K | No | EVA | |
rs3388589947 | 386 | F>Y | No | EVA | |
rs3388588474 | 387 | Q>R | No | EVA | |
rs3388591525 | 391 | A>S | No | EVA | |
rs51753123 | 418 | P>L | No | EVA | |
rs3392178490 | 423 | C>W | No | EVA | |
rs261198974 | 424 | A>V | No | EVA |
No associated diseases with Q6HA09
Functions
3 GO annotations of cellular component
Name | Definition |
---|---|
cortical granule | A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy. |
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
Name | Definition |
---|---|
aspartic-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
glutamic-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. |
metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
zinc ion binding | Binding to a zinc ion (Zn). |
6 GO annotations of biological process
Name | Definition |
---|---|
cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
fertilization | The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). |
negative regulation of binding of sperm to zona pellucida | Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida. |
positive regulation of protein processing | Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. |
prevention of polyspermy | The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. |
proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
21 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q9DER7 | TLL1 | Tolloid-like protein 1 | Gallus gallus (Chicken) | PR |
P25723 | tld | Dorsal-ventral patterning protein tolloid | Drosophila melanogaster (Fruit fly) | PR |
O43897 | TLL1 | Tolloid-like protein 1 | Homo sapiens (Human) | PR |
P98066 | TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein | Homo sapiens (Human) | PR |
P13497 | BMP1 | Bone morphogenetic protein 1 | Homo sapiens (Human) | PR |
Q9Y6L7 | TLL2 | Tolloid-like protein 2 | Homo sapiens (Human) | PR |
O08859 | Tnfaip6 | Tumor necrosis factor-inducible gene 6 protein | Mus musculus (Mouse) | PR |
P98063 | Bmp1 | Bone morphogenetic protein 1 | Mus musculus (Mouse) | PR |
Q9WVM6 | Tll2 | Tolloid-like protein 2 | Mus musculus (Mouse) | PR |
Q62381 | Tll1 | Tolloid-like protein 1 | Mus musculus (Mouse) | PR |
Q20176 | nas-39 | Zinc metalloproteinase nas-39 | Caenorhabditis elegans | PR |
Q21252 | nas-3 | Zinc metalloproteinase nas-3 | Caenorhabditis elegans | PR |
O62243 | nas-1 | Zinc metalloproteinase nas-1 | Caenorhabditis elegans | PR |
Q18439 | nas-8 | Zinc metalloproteinase nas-8 | Caenorhabditis elegans | PR |
Q20942 | nas-38 | Zinc metalloproteinase nas-38 | Caenorhabditis elegans | PR |
Q9U3S9 | nas-6 | Zinc metalloproteinase nas-6 | Caenorhabditis elegans | PR |
P55113 | nas-7 | Zinc metalloproteinase nas-7 | Caenorhabditis elegans | PR |
P55112 | nas-4 | Zinc metalloproteinase nas-4 | Caenorhabditis elegans | PR |
Q22398 | nas-22 | Zinc metalloproteinase nas-22 | Caenorhabditis elegans | PR |
P55115 | nas-15 | Zinc metalloproteinase nas-15 | Caenorhabditis elegans | PR |
O57460 | tll1 | Dorsal-ventral patterning tolloid-like protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MGIMGSLWPW | ILTMLSLLGL | SMGAPSASRC | SGVCSTSVPE | GFTPEGSPVF | QDKDIPAINQ |
70 | 80 | 90 | 100 | 110 | 120 |
GLISEETPES | SFLVEGDIIR | PSPFRLLSVT | NNKWPKGVGG | FVEIPFLLSR | KYDELSRRVI |
130 | 140 | 150 | 160 | 170 | 180 |
MDAFAEFERF | TCIRFVAYHG | QRDFVSILPM | AGCFSGVGRS | GGMQVVSLAP | TCLRKGRGIV |
190 | 200 | 210 | 220 | 230 | 240 |
LHELMHVLGF | WHEHSRADRD | RYIQVNWNEI | LPGFEINFIK | SRSTNMLVPY | DYSSVMHYGR |
250 | 260 | 270 | 280 | 290 | 300 |
FAFSWRGQPT | IIPLWTSSVH | IGQRWNLSTS | DITRVCRLYN | CSRSVPDSHG | RGFEAQSDGS |
310 | 320 | 330 | 340 | 350 | 360 |
SLTPASISRL | QRLLEALSEE | SGSSAPSGSR | TGGQSIAGLG | NSQQGWEHPP | QSTFSVGALA |
370 | 380 | 390 | 400 | 410 | 420 |
RPPQMLADAS | KSGPGAGADS | LSLEQFQLAQ | APTVPLALFP | EARDKPAPIQ | DAFERLAPLP |
430 | |||||
GGCAPGSHIR | EVPRD |