Q6GVM6

SS
Gene name
DDX3Y
Protein name
ATP-dependent RNA helicase DDX3Y
Names
EC 3.6.4.13 , DEAD box protein 3, Y-chromosomal
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
ptr:449508
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

DEAD-box proteins utilize ATP to bind and remodel RNA and RNA-protein complexes. The Ded1/DDX3 subfamily of DEAD-box proteins is of particular interest as their function during protein translation, are essential for viability, and are frequently altered in human malignancies. <br>There is a unique interdomain interaction between the two ATPase domains (DEAD box helicase domain and helicase domain) in which the C-terminal helicase domain clashes with the RNA-binding surface. Destabilizing this interaction accelerates RNA duplex unwinding, suggesting that it is present in solution and inhibitory for catalysis. The N-terminal extension to the DEAD box helicase interacts with DEAD box helicase domain and C-terminal helicase domain, and stabilizes the autoinhibited state of DDX3X.

Autoinhibitory domains (AIDs)

412-573 (C-terminal helicase domain) SS

Target domain

202-389 (DEAD box helicase domain)

Relief mechanism

Assay

202-389 (DEAD box helicase domain) SS

Target domain

412-573 (C-terminal helicase domain)

Relief mechanism

Assay

130-180 (N-terminal extension) SS

Target domain

202-389 (DEAD box helicase domain);412-573 (C-terminal helicase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GVM6

Entry ID Method Resolution Chain Position Source
AF-Q6GVM6-F1 Predicted AlphaFoldDB

No variants for Q6GVM6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GVM6

No associated diseases with Q6GVM6

5 regional properties for Q6GVM6

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 343 - 351 IPR000629
domain Helicase, C-terminal domain-like 412 - 573 IPR001650
domain DEAD/DEAH box helicase domain 202 - 389 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 197 - 416 IPR014001
domain RNA helicase, DEAD-box type, Q motif 178 - 206 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gamete generation The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5W5U4 DDX4 Probable ATP-dependent RNA helicase DDX4 Bos taurus (Bovine) SS
P60024 DDX39B Spliceosome RNA helicase DDX39B Pan troglodytes (Chimpanzee) PR
O00571 DDX3X ATP-dependent RNA helicase DDX3X Homo sapiens (Human) EV
Q9NQI0 DDX4 Probable ATP-dependent RNA helicase DDX4 Homo sapiens (Human) SS
O15523 DDX3Y ATP-dependent RNA helicase DDX3Y Homo sapiens (Human) SS
Q61496 Ddx4 ATP-dependent RNA helicase DDX4 Mus musculus (Mouse) SS
P16381 D1Pas1 Putative ATP-dependent RNA helicase Pl10 Mus musculus (Mouse) SS
Q62095 Ddx3y ATP-dependent RNA helicase DDX3Y Mus musculus (Mouse) SS
Q62167 Ddx3x ATP-dependent RNA helicase DDX3X Mus musculus (Mouse) SS
Q6GWX0 DDX4 Probable ATP-dependent RNA helicase DDX4 Sus scrofa (Pig) SS
Q2R1M8 Os11g0599500 DEAD-box ATP-dependent RNA helicase 52C Oryza sativa subsp. japonica (Rice) SS
Q6Z4K6 PL10B DEAD-box ATP-dependent RNA helicase 52B Oryza sativa subsp. japonica (Rice) SS
Q75HJ0 PL10A DEAD-box ATP-dependent RNA helicase 37 Oryza sativa subsp. japonica (Rice) SS
O01836 glh-3 ATP-dependent RNA helicase glh-3 Caenorhabditis elegans PR
D0PV95 laf-1 ATP-dependent RNA helicase laf-1 Caenorhabditis elegans SS
Q84W89 RH37 DEAD-box ATP-dependent RNA helicase 37 Arabidopsis thaliana (Mouse-ear cress) SS
Q8LA13 RH11 DEAD-box ATP-dependent RNA helicase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2F9 RH52 DEAD-box ATP-dependent RNA helicase 52 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MSHVVVKNDP ELDQQLANLD LNSEKQSGGA SRASKGRYIP PHLRNREASK GFHDKDSSGW
70 80 90 100 110 120
SCSKDKDAYN SFGSRDSRGK PGYFSERGSG SRGRFDDRGR SDYDGIGNRD RPGFGRFERN
130 140 150 160 170 180
GHSRWCDKSD EDDWSKPLPP SERLEQELFS GGNTGINFEK YDDIPVEATG SNCPPHIENF
190 200 210 220 230 240
GDIDMGEIIM GNIQLTRYTR PTPVQKHAIP IIKGKRDLMA CAQTGSGKTA AFLLPILSQI
250 260 270 280 290 300
YTDGPGEALK AVKENGRYGR RKQYPISLVL APTRELAVQI YEEARKFSYR SRVRPCVVYG
310 320 330 340 350 360
GADIGQQIRD LERGCHLLVA TPGRLVDMME RGKIGLDFCK YLVLDEADRM LDMGFEPQIR
370 380 390 400 410 420
RIVEQDTMPP KGVRHTMMFS ATFPKEIQML ARDFLDEYIF LAVGRVGSTS ENITQKVVWV
430 440 450 460 470 480
EDLDKRSFLL DILGAAGTDS LTLVFVETKK GADSLEDFLY HEGYACTSIH GDRSQRDREE
490 500 510 520 530 540
ALHQFRSGKS PILVATAVAA RGLDISNVRH VINFDLPSDI EEYVHRIGRT GRVGNLGLAT
550 560 570 580 590 600
SFFNEKNINI TKDLLDLLVE AKQEVPSWLE NMAYEHQYKG GSRGRSKSNR FSGGFGARDY
610 620 630 640 650
RQSSGSSSSG FGASRGSSSR SGGGGYGNSR GFGGGGYGGF YNSDGYGGNY NSQGVDWWGN