Q6GUQ1
Gene name |
Egfl8 (Ng3) |
Protein name |
Epidermal growth factor-like protein 8 |
Names |
EGF-like protein 8 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:81701 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6GUQ1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6GUQ1-F1 | Predicted | AlphaFoldDB |
13 variants for Q6GUQ1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3407452100 | 26 | T>A | No | EVA | |
| rs3389455608 | 59 | K>T | No | EVA | |
| rs3407270940 | 74 | Y>C | No | EVA | |
| rs3389435972 | 98 | Q>K | No | EVA | |
| rs3389466101 | 109 | T>I | No | EVA | |
| rs3389435909 | 122 | G>R | No | EVA | |
| rs3389435984 | 127 | P>Q | No | EVA | |
| rs3389455877 | 150 | A>D | No | EVA | |
| rs3389455587 | 150 | A>T | No | EVA | |
| rs3389455924 | 162 | T>K | No | EVA | |
| rs3389449527 | 173 | P>L | No | EVA | |
| rs3389455164 | 213 | R>T | No | EVA | |
| rs3407623693 | 231 | T>K | No | EVA |
No associated diseases with Q6GUQ1
6 regional properties for Q6GUQ1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| ptm | EGF-type aspartate/asparagine hydroxylation site | 159 - 170 | IPR000152 |
| domain | EGF-like domain | 111 - 142 | IPR000742-1 |
| domain | EGF-like domain | 147 - 184 | IPR000742-2 |
| domain | EGF-like calcium-binding domain | 144 - 184 | IPR001881 |
| domain | EMI domain | 34 - 112 | IPR011489 |
| conserved_site | EGF-like calcium-binding, conserved site | 144 - 168 | IPR018097 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure development | The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q868Z9 | Ppn | Papilin | Drosophila melanogaster (Fruit fly) | SS |
| Q04721 | NOTCH2 | Neurogenic locus notch homolog protein 2 | Homo sapiens (Human) | EV |
| P46531 | NOTCH1 | Neurogenic locus notch homolog protein 1 | Homo sapiens (Human) | EV |
| P21941 | MATN1 | Cartilage matrix protein | Homo sapiens (Human) | PR |
| Q01705 | Notch1 | Neurogenic locus notch homolog protein 1 | Mus musculus (Mouse) | SS |
| Q91V88 | Npnt | Nephronectin | Mus musculus (Mouse) | PR |
| O35516 | Notch2 | Neurogenic locus notch homolog protein 2 | Mus musculus (Mouse) | SS |
| P51942 | Matn1 | Cartilage matrix protein | Mus musculus (Mouse) | PR |
| Q9QW30 | Notch2 | Neurogenic locus notch homolog protein 2 | Rattus norvegicus (Rat) | SS |
| Q07008 | Notch1 | Neurogenic locus notch homolog protein 1 | Rattus norvegicus (Rat) | SS |
| P13508 | glp-1 | Protein glp-1 | Caenorhabditis elegans | EV |
| A2RUV0 | notch1 | Neurogenic locus notch homolog protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| P46530 | notch1a | Neurogenic locus notch homolog protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLWAELCIS | LRGLSFFLVL | MTGEGTRGGS | FKESLGVCSK | QTLLVPLRYN | ESYSQPVYKP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLTLCAGRRI | CSTYRTTYRV | AWREVRREVP | QTHVVCCQGW | KKPHPGALTC | DAICSKPCLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGVCTGPDRC | ECAPGWGGKH | CHVDVDECRA | SLTLCSHGCL | NTLGSFLCSC | PHPLVLGLDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RTCAGGPPES | PTSASILSVA | VREADSEEER | ALRWEVAELR | GRLEKLEQWA | TQAGAWVRAV |
| 250 | 260 | 270 | 280 | 290 | |
| LPMPPEELRP | EQVAELWGRG | DRIESLSDQV | LLLEERLGAC | ACEDNSLGPS | LRG |