Q6GLH8
Gene name |
sox17b.2 |
Protein name |
Transcription factor Sox-17-beta.2 |
Names |
SRY (sex determining region Y)-box 17-beta.2 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:100038235 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6GLH8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6GLH8-F1 | Predicted | AlphaFoldDB |
No variants for Q6GLH8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6GLH8 | |||||
No associated diseases with Q6GLH8
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure morphogenesis | The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. |
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| gastrulation | A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| vasculogenesis | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48435 | SOX11 | Transcription factor SOX-11 | Gallus gallus (Chicken) | SS |
| P48436 | SOX9 | Transcription factor SOX-9 | Homo sapiens (Human) | PR |
| O94993 | SOX30 | Transcription factor SOX-30 | Homo sapiens (Human) | PR |
| P35716 | SOX11 | Transcription factor SOX-11 | Homo sapiens (Human) | EV |
| O15370 | SOX12 | Transcription factor SOX-12 | Homo sapiens (Human) | SS |
| Q04887 | Sox9 | Transcription factor SOX-9 | Mus musculus (Mouse) | PR |
| Q04886 | Sox8 | Transcription factor SOX-8 | Mus musculus (Mouse) | SS |
| Q04888 | Sox10 | Transcription factor SOX-10 | Mus musculus (Mouse) | PR |
| Q7M6Y2 | Sox11 | Transcription factor SOX-11 | Mus musculus (Mouse) | SS |
| Q04890 | Sox12 | Transcription factor SOX-12 | Mus musculus (Mouse) | SS |
| Q05738 | Sry | Sex-determining region Y protein | Mus musculus (Mouse) | SS |
| P0C1G9 | Sox11 | Transcription factor SOX-11 | Rattus norvegicus (Rat) | SS |
| Q8T3B9 | sem-2 | Transcription factor sem-2 | Caenorhabditis elegans | SS |
| Q8AWH2 | sox17b.1 | Transcription factor Sox-17-beta.1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q66JF1 | sox11 | Transcription factor Sox-11 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSPDGGYAS | DDQFHGNCSV | PIMMGQYEWT | DPLTMFQDAK | TKKEAGSANS | RGKAEARIRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PMNAFMVWAK | DERKRLAQQN | PDLHNAELSK | MLGKSWKSLT | LASKRPFVKE | AERLRVQHIQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DYPDYKYRPR | RKKQVKREEE | GFLPSADIPG | PQVMGCNAMV | GQNYKMQYSG | QNSQQSQITP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AGYFEDHNPV | GFYYRGYNVP | KYYMSQNSSG | YCSPPTQGEY | QALSYNFNSS | YIPYQQNASA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PAMGKQMAVK | ENIIQESPEH | GIMGCQVSPQ | MYNGQMYVPE | CAKTHPVAQT | EQHSSLHQSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QMVTQNYLPS | QQDGHLESDI | DKTEFDQYLM | YEPKSDTELI | YTIDQDSGAY | STNLLPSLIS |
| 370 | |||||
| EANSVCYYDY | CGV |