Q6GLD8

PR
Gene name
cdk9 (TGas123e01.1)
Protein name
Cyclin-dependent kinase 9
Names
Cell division protein kinase 9
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:448039
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

307-376 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

170-197 (Activation loop from InterPro)

Target domain

19-319 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6GLD8

Entry ID Method Resolution Chain Position Source
AF-Q6GLD8-F1 Predicted AlphaFoldDB

No variants for Q6GLD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GLD8

No associated diseases with Q6GLD8

3 regional properties for Q6GLD8

Type Name Position InterPro Accession
domain Protein kinase domain 19 - 319 IPR000719
active_site Serine/threonine-protein kinase, active site 149 - 161 IPR008271
binding_site Protein kinase, ATP binding site 25 - 48 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

4 GO annotations of biological process

Name Definition
positive regulation of protein localization to chromatin Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5EAB2 CDK9 Cyclin-dependent kinase 9 Bos taurus (Bovine) PR
Q5ZKN1 CDK9 Cyclin-dependent kinase 9 Gallus gallus (Chicken) PR
P50750 CDK9 Cyclin-dependent kinase 9 Homo sapiens (Human) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q641Z4 Cdk9 Cyclin-dependent kinase 9 Rattus norvegicus (Rat) PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVM9 At1g54610 Probable serine/threonine-protein kinase At1g54610 Arabidopsis thaliana (Mouse-ear cress) PR
A4IIW7 cdk14 Cyclin-dependent kinase 14 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6P3N6 cdk8 Cyclin-dependent kinase 8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV LMENEKEGFP
70 80 90 100 110 120
ITALREIKIL QLLKHENVVN LIEICRTKIS PTANQYNRCK GTIFLVFDFC EHDLAGLLSN
130 140 150 160 170 180
AHVKFTLSEI KKVMQMLLNG LYYIHRNKIL HRDMKAANVL ITRDGVLKLA DFGLARAFSL
190 200 210 220 230 240
AKNSQPNKYT NRVVTLWYRP PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH
250 260 270 280 290 300
QLTLISQLCG SITPEVWPNV DKYELYQKLE LPKGQKRKVK ERLKAYVKDL YALDLIDKLL
310 320 330 340 350 360
VLDPAQRIDS DDALNHDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG GHMPQQPANQ
370
ARNPAATNQS EFDRVF