Q6F2E7
PR
Gene name |
sox9 |
Protein name |
Transcription factor Sox-9 |
Names |
Xt-sox9 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:549607 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6F2E7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6F2E7-F1 | Predicted | AlphaFoldDB |
No variants for Q6F2E7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6F2E7 | |||||
No associated diseases with Q6F2E7
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| ubiquitin-like protein ligase binding | Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| cartilage development | The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
| chondrocyte differentiation | The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. |
| gonadal mesoderm development | The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. |
| growth plate cartilage chondrocyte growth | The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| morphogenesis of an epithelium | The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of fatty acid oxidation | Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation. |
| negative regulation of osteoblast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| neural crest formation | The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. |
| oligodendrocyte differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. |
| otic placode formation | The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain. |
| positive regulation of chondrocyte differentiation | Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to fatty acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNLLDPFMKM | TEEQDKCMSG | APSPTMSEDS | AGSPCPSGSG | SDTENTRPQE | NTFPKGDPEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKETEDEKFP | VCIREAVSQV | LKGYDWTLVP | MPVRVNGSSK | SKPHVKRPMN | AFMVWAQAAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKLADQYPHL | HNAELSKTLG | KLWRLLNEGE | KRPFVEEAER | LRIQHKKDHP | DYKYQPRRRK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVKNGQSEQE | DGAEQTHISP | NAIFKALQAD | SPHSASSMSE | VHSPGEHSGQ | SQGPPTPPTT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKTDVQPGKP | DLKREGRPLQ | ESGRQPPHID | FRDVDIGELS | SEVISTIETF | DVNEFDQYLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PNGHPGVGST | QAPYTGSYGI | NSTPSATPGA | GPAWMSKQQQ | QQQQQPQPPQ | HSLSTINSEQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SQSQQRTHIK | TEQLSPSHYS | DQQQQHSPQQ | LNYSSFNLQH | YSSSYPTITR | AQYDYTEHQG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SNSYYSHASG | QNSGLYSNFS | YMNPSQRPMY | TPIADTTGVP | SIPQTHSPQH | WEQPVYTQLT |
| RP |