Q6F2E2

PR
Gene name
vex1
Protein name
Homeobox protein vex1
Names
Homeodomain transcription factor vex-1, Ventral homeobox protein
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

52-150 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6F2E2

Entry ID Method Resolution Chain Position Source
AF-Q6F2E2-F1 Predicted AlphaFoldDB

No variants for Q6F2E2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6F2E2

No associated diseases with Q6F2E2

2 regional properties for Q6F2E2

Type Name Position InterPro Accession
domain Homeobox domain 127 - 191 IPR001356
conserved_site Homeobox, conserved site 162 - 185 IPR017970

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

5 GO annotations of biological process

Name Definition
BMP signaling pathway The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
determination of ventral identity The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A3BYC1 HOX25 Homeobox-leucine zipper protein HOX25 Oryza sativa subsp japonica (Rice) PR
P46603 HAT9 Homeobox-leucine zipper protein HAT9 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEKRPYSVAW LSESSQRKPL CTNVDLLGYK SGNPDLPPNR EYNVSLPSRV ILPTPDYREK
70 80 90 100 110 120
ENYCGRNVHN GERSPPVRDQ LHFHPAPQEL TTSRRTSIEV SAESSTDQRV IGMTDTNKKT
130 140 150 160 170 180
ISVCDEDAAS RARTKFTAEQ LEELEKSFKE NRYIGSSEKR RLSKVLKLSE NQIKTWFQNR
190 200 210 220 230 240
RMKFKRQTQD ARVEAFFSGL YLPYYGYPDL PTPGYSVQSE FPVLAPQTMA ASSIPFGPLH
250 260 270 280
STVMSPGLHP AIPSANLGSY PCSSMLVRPI LNEPTRQRYS PY