Q6E804

SS
Gene name
NOD2 (CARD15)
Protein name
Nucleotide-binding oligomerization domain-containing protein 2
Names
Caspase recruitment domain-containing protein 15
Species
Bos taurus (Bovine)
KEGG Pathway
bta:444867
EC number
Protein Class

Descriptions

NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that promotes secretion of the proinflammatory cytokine IL-1β. NOT2 through its N-terminal caspase recruitment domain directly binds and activates caspase-1 to trigger IL-1β processing and secretion in MDP-stimulated macrophages, wherease the C-terminal leucine-rich repeats (LRR) of NOD2 prevent caspase-1 activation in non-stimulated cells. Removal of the LRR rendered NOD2 a constitutive activator of pro-IL-1β processing and caspase-1. The autoinhibitory region was inferred by sequence similarity with the human NOD2 (Q9HC29).

Autoinhibitory domains (AIDs)

764-1008 (Leucine-rich repeats) SS

Target domain

1-178 (CARD domains)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6E804

Entry ID Method Resolution Chain Position Source
AF-Q6E804-F1 Predicted AlphaFoldDB

443 variants for Q6E804

Variant ID(s) Position Change Description Diseaes Association Provenance
rs444791955 2 C>S No Ensembl
rs437038633 6 A>D No Ensembl
rs469645580 6 A>P No Ensembl
rs469645580 6 A>T No Ensembl
rs455644588 10 Q>E No Ensembl
rs473977692 14 L>M No Ensembl
rs434592449 16 E>* No Ensembl
rs471886029 22 S>A No Ensembl
rs457309128 23 L>R No Ensembl
rs475824632 26 F>C No Ensembl
rs443114295 27 E>A No Ensembl
rs461674002 30 L>P No Ensembl
rs440590667 34 L>R No Ensembl
rs480027293 34 L>V No Ensembl
rs459123465 35 S>A No Ensembl
rs444927957 37 E>G No Ensembl
rs481642539 38 V>A No Ensembl
rs469582296 38 V>F No Ensembl
rs449046493 39 L>R No Ensembl
rs453071332 42 E>* No Ensembl
rs465195531 43 D>A No Ensembl
rs432421332 44 Y>D No Ensembl
rs457447970 51 G>V No Ensembl
rs475763211 53 P>L No Ensembl
rs455096285 56 H>L No Ensembl
rs442820849 56 H>N No Ensembl
rs473723085 57 L>W No Ensembl
rs440728246 58 A>D No Ensembl
rs458959795 60 R>L No Ensembl
rs477429829 64 T>P No Ensembl
rs438427539 65 I>L No Ensembl
rs463298432 66 W>C No Ensembl
rs448865599 68 K>* No Ensembl
rs467379544 69 G>R No Ensembl
rs109774463 70 T>A No Ensembl
rs446731829 70 T>S No Ensembl
rs465132226 71 W>* No Ensembl
rs432161734 73 C>W No Ensembl
rs457386940 78 A>S No Ensembl
rs469477392 83 A>D No Ensembl
rs454904682 84 Q>K No Ensembl
rs473419197 84 Q>L No Ensembl
rs434246477 86 D>A No Ensembl
rs517981621 86 D>N No Ensembl
rs444604305 88 Q>H No Ensembl
rs452707835 88 Q>K No Ensembl
rs470969409 88 Q>P No Ensembl
rs463034937 89 P>R No Ensembl
rs442523972 90 P>H No Ensembl
rs475537971 90 P>T No Ensembl
rs479472888 91 E>* No Ensembl
rs446696891 91 E>V No Ensembl
rs458839802 93 P>S No Ensembl
rs477151420 94 S>G No Ensembl
rs450714741 94 S>R No Ensembl
rs477151420 94 S>R No Ensembl
rs469212160 95 S>T No Ensembl
rs436471182 95 S>Y No Ensembl
rs448508600 96 W>G No Ensembl
rs448508600 96 W>R No Ensembl
rs466955421 97 D>A No Ensembl
rs433983593 99 H>D No Ensembl
rs452646550 99 H>P No Ensembl
rs471108949 100 S>T No Ensembl
rs475234127 102 H>L No Ensembl
rs456555908 102 H>N No Ensembl
rs475234127 102 H>P No Ensembl
rs461016531 103 P>Q No Ensembl
rs442476181 103 P>S No Ensembl
rs472994591 105 R>G No Ensembl
rs472994591 105 R>S No Ensembl
rs458575766 106 D>A No Ensembl
rs477290618 107 L>M No Ensembl
rs477290618 107 L>V No Ensembl
rs481292259 108 Q>H No Ensembl
rs462724970 108 Q>K No Ensembl
rs448527057 109 S>R No Ensembl
rs467037696 110 H>N No Ensembl
rs434121907 110 H>P No Ensembl
rs445997739 110 H>Q No Ensembl
rs445997739 110 H>Q No Ensembl
rs464430184 111 R>Q No Ensembl
rs456693284 112 P>R No Ensembl
rs468762934 113 A>T No Ensembl
rs473073914 118 L>I No Ensembl
rs440171894 118 L>P No Ensembl
rs452110227 120 G>D No Ensembl
rs444312604 122 V>G No Ensembl
rs134293179 123 E>G No Ensembl
rs462819468 124 G>V No Ensembl
rs460396490 125 V>G No Ensembl
rs441792663 125 V>L No Ensembl
rs136745291 126 L>R No Ensembl
rs446134767 127 D>A No Ensembl
rs464363241 127 D>E No Ensembl
rs446134767 127 D>G No Ensembl
rs478901239 127 D>H No Ensembl
rs450320701 131 Q>P No Ensembl
rs450320701 131 Q>R No Ensembl
rs468853907 133 G>C No Ensembl
rs435933639 133 G>V No Ensembl
rs466418393 134 F>I No Ensembl
rs433634811 134 F>L No Ensembl
rs452241221 135 I>L No Ensembl
rs444048971 137 Q>E No Ensembl
rs456162093 137 Q>H No Ensembl
rs474902600 138 Y>* No Ensembl
rs441944817 140 T>N No Ensembl
rs478631658 142 E>D No Ensembl
rs460282792 142 E>K No Ensembl
rs439625107 143 I>F No Ensembl
rs482777116 144 R>K No Ensembl
rs482777116 144 R>T No Ensembl
rs449999617 145 R>P No Ensembl
rs468636648 147 I>T No Ensembl
rs480961174 149 T>P No Ensembl
rs447990125 150 S>A No Ensembl
rs466332921 152 Q>P No Ensembl
rs466332921 152 Q>R No Ensembl
rs481555869 189 D>E No Ensembl
rs448517339 191 A>V No Ensembl
rs466770822 195 Y>S No Ensembl
rs208027983 196 V>M No Ensembl
rs478825597 199 L>M No Ensembl
rs446259236 206 Q>H No Ensembl
rs464694316 209 F>L No Ensembl
rs438322263 211 S>R No Ensembl
rs456657821 216 A>V No Ensembl
rs468826558 217 E>D No Ensembl
rs436060989 221 L>V No Ensembl
rs454641092 223 E>K No Ensembl
rs472952182 223 E>V No Ensembl
rs452173784 224 V>L No Ensembl
rs470856484 225 Y>S No Ensembl
rs444349204 226 T>K No Ensembl
rs444349204 226 T>R No Ensembl
rs462695367 227 E>* No Ensembl
rs474840771 227 E>A No Ensembl
rs442026992 228 N>D No Ensembl
rs460479271 228 N>K No Ensembl
rs478956855 229 V>F No Ensembl
rs445993451 230 L>R No Ensembl
rs458182688 232 I>V No Ensembl
rs483326145 235 E>A No Ensembl
rs450386271 236 V>E No Ensembl
rs468717267 238 M>V No Ensembl
rs435787063 239 A>D No Ensembl
rs466666242 243 Q>E No Ensembl
rs433696752 244 Q>H No Ensembl
rs470627036 249 L>I No Ensembl
rs437850461 249 L>P No Ensembl
rs456424822 257 T>A No Ensembl
rs437154744 258 R>H No Ensembl
rs460214150 260 H>R No Ensembl
rs472492197 261 F>S No Ensembl
rs439694349 266 D>E No Ensembl
rs458041182 271 V>A No Ensembl
rs483084393 272 G>C No Ensembl
rs450260020 273 E>Q No Ensembl
rs462455217 276 S>G No Ensembl
rs480962844 276 S>N No Ensembl
rs447878938 276 S>R No Ensembl
rs480962844 276 S>T No Ensembl
rs433632881 277 G>A No Ensembl
rs466395991 277 G>R No Ensembl
rs466395991 277 G>S No Ensembl
rs464080360 278 K>T No Ensembl
rs456112026 279 S>R No Ensembl
rs437595571 279 S>T No Ensembl
rs435487364 280 T>K No Ensembl
rs474914650 280 T>P No Ensembl
rs453761130 281 L>R No Ensembl
rs472228454 283 Q>H No Ensembl
rs439631038 284 Q>K No Ensembl
rs451791231 284 Q>P No Ensembl
rs443611723 285 L>Q No Ensembl
rs441562485 289 W>* No Ensembl
rs459901696 290 A>G No Ensembl
rs445642117 292 G>E No Ensembl
rs478410330 292 G>R No Ensembl
rs464257792 299 L>P No Ensembl
rs482825940 300 F>L No Ensembl
rs449647054 301 V>L No Ensembl
rs468036235 302 F>S No Ensembl
rs453898208 311 C>R No Ensembl
rs432973914 320 T>K No Ensembl
rs451442763 321 L>R No Ensembl
rs476731664 327 C>R No Ensembl
rs443729735 329 P>S No Ensembl
rs474209846 330 D>E No Ensembl
rs460036876 339 V>D No Ensembl
rs478549296 343 H>R No Ensembl
rs463953327 346 R>S No Ensembl
rs482745736 347 I>M No Ensembl
rs449727853 348 L>I No Ensembl
rs480030286 349 L>I No Ensembl
rs433117803 351 F>S No Ensembl
rs451466825 357 F>L No Ensembl
rs437254344 361 F>L No Ensembl
rs455838278 365 E>K No Ensembl
rs474144116 369 C>S No Ensembl
rs797913048 370 P>L No Ensembl
rs453369409 376 V>G No Ensembl
rs434767682 376 V>I No Ensembl
rs439109615 382 N>T No Ensembl
rs463939790 383 L>V No Ensembl
rs476024064 387 N>T No Ensembl
rs443274792 390 K>E No Ensembl
rs461683967 390 K>R No Ensembl
rs480167399 391 N>I No Ensembl
rs459218628 392 A>P No Ensembl
rs469958759 395 V>A No Ensembl
rs445107756 395 V>L No Ensembl
rs436981893 396 L>F No Ensembl
rs434906784 401 S>R No Ensembl
rs471792710 403 V>G No Ensembl
rs432628992 406 S>R No Ensembl
rs457577241 407 L>P No Ensembl
rs476005147 408 R>P No Ensembl
rs442976808 411 V>A No Ensembl
rs461420252 412 R>P No Ensembl
rs440896613 416 S>T No Ensembl
rs445080274 418 K>N No Ensembl
rs459155436 418 K>Q No Ensembl
rs477866036 418 K>T No Ensembl
rs449083900 427 L>M No Ensembl
rs479879824 428 Y>C No Ensembl
rs467594537 428 Y>H No Ensembl
rs446981944 433 H>D No Ensembl
rs446981944 433 H>N No Ensembl
rs432379033 435 E>D No Ensembl
rs469657184 438 V>G No Ensembl
rs457385557 438 V>L No Ensembl
rs454954963 439 A>G No Ensembl
rs436693515 439 A>P No Ensembl
rs436693515 439 A>S No Ensembl
rs473426998 440 D>A No Ensembl
rs440827083 440 D>E No Ensembl
rs452932340 441 R>P No Ensembl
rs471551352 442 L>P No Ensembl
rs438372117 444 C>W No Ensembl
rs482092704 446 L>F No Ensembl
rs482092704 446 L>I No Ensembl
rs442764297 446 L>P No Ensembl
rs479620188 447 R>S No Ensembl
rs446920236 449 T>P No Ensembl
rs465421454 449 T>S No Ensembl
rs477582359 450 S>P No Ensembl
rs450783426 450 S>W No Ensembl
rs455090043 453 H>N No Ensembl
rs466956607 453 H>P No Ensembl
rs434146183 454 G>C No Ensembl
rs471457006 456 C>G No Ensembl
rs438510670 457 H>D No Ensembl
rs464481571 457 H>P No Ensembl
rs475412270 458 L>P No Ensembl
rs442705505 459 P>H No Ensembl
rs479757348 460 V>L No Ensembl
rs458784802 463 W>* No Ensembl
rs477533020 463 W>C No Ensembl
rs450997507 464 M>L No Ensembl
rs462876246 466 S>A No Ensembl
rs448439611 468 C>G No Ensembl
rs467090293 468 C>S No Ensembl
rs434281122 472 L>Q No Ensembl
rs446178119 473 L>F No Ensembl
rs464785134 477 R>G No Ensembl
rs432026324 477 R>L No Ensembl
rs522420803 485 D>Y No Ensembl
rs435974984 486 M>V No Ensembl
rs454565710 487 Y>N No Ensembl
rs473280958 488 L>R No Ensembl
rs440318591 489 L>V No Ensembl
rs458652739 492 R>G No Ensembl
rs470823199 493 H>P No Ensembl
rs448374534 497 H>N No Ensembl
rs460403568 497 H>R No Ensembl
rs517655041 505 T>N No Ensembl
rs438193065 506 H>R No Ensembl
rs450247843 508 L>R No Ensembl
rs454502159 510 P>A No Ensembl
rs473013705 510 P>R No Ensembl
rs433838558 512 L>V No Ensembl
rs452389328 514 Q>K No Ensembl
rs470919495 516 R>G No Ensembl
rs444208292 518 P>S No Ensembl
rs474887432 524 G>C No Ensembl
rs474887432 524 G>R No Ensembl
rs460338494 525 R>P No Ensembl
rs439842192 527 A>S No Ensembl
rs483350189 532 G>C No Ensembl
rs481084026 537 V>G No Ensembl
rs448205234 538 F>S No Ensembl
rs433572346 541 K>N No Ensembl
rs464447588 544 Q>P No Ensembl
rs437915557 545 A>E No Ensembl
rs456147895 547 H>N No Ensembl
rs474621934 547 H>P No Ensembl
rs474621934 547 H>R No Ensembl
rs442027027 548 V>I No Ensembl
rs454080385 549 D>A No Ensembl
rs472726501 550 S>G No Ensembl
rs439574973 550 S>N No Ensembl
rs458104765 550 S>R No Ensembl
rs483301143 552 D>G No Ensembl
rs483301143 552 D>V No Ensembl
rs443967282 553 L>V No Ensembl
rs480825928 560 L>P No Ensembl
rs448139281 561 A>G No Ensembl
rs478781673 562 K>N No Ensembl
rs466675589 562 K>Q No Ensembl
rs445603464 563 R>T No Ensembl
rs464143879 564 V>G No Ensembl
rs456281241 565 V>A No Ensembl
rs437820109 565 V>L No Ensembl
rs468156839 568 S>I No Ensembl
rs435350879 568 S>R No Ensembl
rs453822753 569 T>A No Ensembl
rs472724909 569 T>K No Ensembl
rs451654475 570 A>P No Ensembl
rs476638970 572 L>P No Ensembl
rs462449940 576 H>N No Ensembl
rs474546991 578 T>A No Ensembl
rs474546991 578 T>P No Ensembl
rs459923496 580 Q>K No Ensembl
rs457698386 587 Y>S No Ensembl
rs482426718 588 L>R No Ensembl
rs468299851 589 A>P No Ensembl
rs435491629 590 L>F No Ensembl
rs465950475 591 S>G No Ensembl
rs433235441 592 A>S No Ensembl
rs476558478 593 D>A No Ensembl
rs451717293 593 D>Y No Ensembl
rs437192096 594 T>P No Ensembl
rs455762809 594 T>S No Ensembl
rs474473608 597 S>F No Ensembl
rs441562574 599 L>R No Ensembl
rs459913745 603 F>V No Ensembl
rs471983443 608 P>H No Ensembl
rs471983443 608 P>R No Ensembl
rs482562852 613 L>M No Ensembl
rs449578368 622 L>Q No Ensembl
rs480295964 626 R>G No Ensembl
rs447509461 629 E>G No Ensembl
rs465939981 631 S>R No Ensembl
rs465939981 631 S>R No Ensembl
rs432980443 632 V>G No Ensembl
rs445076328 633 A>V No Ensembl
rs470270563 634 A>P No Ensembl
rs470270563 634 A>S No Ensembl
rs437320876 635 L>S No Ensembl
rs455699365 637 Q>E No Ensembl
rs474209949 637 Q>R No Ensembl
rs435034576 639 A>P No Ensembl
rs472173659 640 E>A No Ensembl
rs438972940 643 N>T No Ensembl
rs457575777 644 L>P No Ensembl
rs476094203 646 I>V No Ensembl
rs461546933 649 A>P No Ensembl
rs480028255 649 A>V No Ensembl
rs441046515 651 L>R No Ensembl
rs478189797 653 G>E No Ensembl
rs482280886 656 S>T No Ensembl
rs467719401 658 E>* No Ensembl
rs434773398 659 H>L No Ensembl
rs453320210 660 R>G No Ensembl
rs465607108 661 S>G No Ensembl
rs457349259 663 L>R No Ensembl
rs443246080 664 A>G No Ensembl
rs455275960 665 E>G No Ensembl
rs473973002 666 C>G No Ensembl
rs473973002 666 C>R No Ensembl
rs440785336 668 A>G No Ensembl
rs459384557 669 S>P No Ensembl
rs438699513 670 E>G No Ensembl
rs463509004 673 L>V No Ensembl
rs482019110 674 L>P No Ensembl
rs449145193 678 D>G No Ensembl
rs518261693 681 R>Q No Ensembl
rs479985206 683 C>G No Ensembl
rs521828585 689 R>H No Ensembl
rs446785281 691 H>R No Ensembl
rs381076835 693 R>C No Ensembl
rs465396289 696 P>R No Ensembl
rs432647338 701 G>R No Ensembl
rs469361926 715 L>V No Ensembl
rs455016214 729 R>P No Ensembl
rs455016214 729 R>Q No Ensembl
rs473889424 732 V>D No Ensembl
rs110663672 733 C>R No Ensembl
rs434500837 736 N>K No Ensembl
rs471411841 746 G>C No Ensembl
rs438670916 760 R>P No Ensembl
rs463645861 761 H>N No Ensembl
rs475736594 761 H>P No Ensembl
rs442625520 762 L>V No Ensembl
rs461178309 765 P>H No Ensembl
rs446958205 767 A>P No Ensembl
rs477445622 768 L>M No Ensembl
rs450846427 768 L>R No Ensembl
rs436693426 777 D>E No Ensembl
rs448573128 779 G>V No Ensembl
rs467203327 781 E>G No Ensembl
rs452986977 784 L>V No Ensembl
rs431940021 785 P>T No Ensembl
rs456959589 792 A>P No Ensembl
rs445093190 826 N>S No Ensembl
rs463836208 842 C>* No Ensembl
rs482341869 846 F>L No Ensembl
rs449156750 848 A>T No Ensembl
rs462504420 855 H>P No Ensembl
rs433883854 862 E>D No Ensembl
rs433883854 862 E>D No Ensembl
rs445770071 863 V>A No Ensembl
rs445770071 863 V>G No Ensembl
rs464198145 864 L>H No Ensembl
rs438008473 866 Q>R No Ensembl
rs468738634 869 R>T No Ensembl
rs435564583 872 N>I No Ensembl
rs435564583 872 N>T No Ensembl
rs482258635 889 A>P No Ensembl
rs476845868 937 E>A No Ensembl
rs465300298 963 L>P No Ensembl
rs432158250 966 N>T No Ensembl
rs457148607 967 H>L No Ensembl
rs457148607 967 H>P No Ensembl
rs469282645 968 I>L No Ensembl
rs436457764 974 E>D No Ensembl
rs473196130 979 A>G No Ensembl
rs452700537 986 I>L No Ensembl
rs471337407 986 I>M No Ensembl
rs444556442 989 V>F No Ensembl
rs434562043 990 W>L No Ensembl
rs385250413 995 T>S No Ensembl
rs439963942 999 E>K No Ensembl
rs43710288 1007 Q>L No Ensembl
70 T>A No
196 V>M No
505 T>N No
681 R>Q No
689 R>H No
733 C>R No
1007 Q>L No

No associated diseases with Q6E804

9 regional properties for Q6E804

Type Name Position InterPro Accession
domain CARD domain 1 - 88 IPR001315-1
domain CARD domain 107 - 178 IPR001315-2
repeat Leucine-rich repeat 844 - 865 IPR001611-1
repeat Leucine-rich repeat 870 - 893 IPR001611-2
repeat Leucine-rich repeat 900 - 921 IPR001611-3
repeat Leucine-rich repeat 955 - 978 IPR001611-4
domain NACHT nucleoside triphosphatase 266 - 435 IPR007111
domain NOD2, winged helix domain 519 - 560 IPR041075
domain NACHT, LRR and PYD domains-containing protein, helical domain HD2 576 - 730 IPR041267

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Basolateral cell membrane
  • Cytoplasm
  • Mitochondrion
  • Palmitoylation promotes localization to the cell membrane, where it detects bacterial invasion at the point of entry
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
anchored component of plasma membrane The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell surface The external part of the cell wall and/or plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

10 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CARD domain binding Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
muramyl dipeptide binding Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan.
pattern recognition receptor activity Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.
peptidoglycan binding Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein-containing complex binding Binding to a macromolecular complex.

60 GO annotations of biological process

Name Definition
activation of immune response Any process that initiates an immune response.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to muramyl dipeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
cellular response to peptidoglycan Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
detection of bacterium The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
detection of muramyl dipeptide The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
innate immune response in mucosa Any process of the innate immune response that takes place in the mucosal tissues.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
maintenance of gastrointestinal epithelium Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.
negative regulation of inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
negative regulation of interferon-gamma production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
negative regulation of interleukin-12 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
negative regulation of interleukin-18 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.
negative regulation of interleukin-2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
negative regulation of macrophage apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.
negative regulation of NF-kappaB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
negative regulation of T cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
negative regulation of toll-like receptor 2 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
negative regulation of tumor necrosis factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
nucleotide-binding oligomerization domain containing 2 signaling pathway The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.
positive regulation of B cell activation Any process that activates or increases the frequency, rate or extent of B cell activation.
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.
positive regulation of cytokine production involved in immune response Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
positive regulation of cytokine production involved in inflammatory response Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
positive regulation of dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.
positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of gamma-delta T cell activation Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation.
positive regulation of humoral immune response mediated by circulating immunoglobulin Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
positive regulation of interleukin-1 beta production Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
positive regulation of interleukin-10 production Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of interleukin-17 production Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
positive regulation of interleukin-8 production Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of MAP kinase activity Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
positive regulation of monocyte chemotactic protein-1 production Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of NIK/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of nitric-oxide synthase biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
positive regulation of Notch signaling pathway Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
positive regulation of phagocytosis Any process that activates or increases the frequency, rate or extent of phagocytosis.
positive regulation of phosphatidylinositol 3-kinase activity Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
positive regulation of prostaglandin-E synthase activity Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity.
positive regulation of prostaglandin-endoperoxide synthase activity Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
positive regulation of protein K63-linked ubiquitination Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
positive regulation of type 2 immune response Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
positive regulation of xenophagy Any process that activates or increases the frequency, rate or extent of xenophagy.
regulation of neutrophil chemotaxis Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
response to exogenous dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q53B87 NOD2 Nucleotide-binding oligomerization domain-containing protein 2 Pan troglodytes (Chimpanzee) SS
Q9HC29 NOD2 Nucleotide-binding oligomerization domain-containing protein 2 Homo sapiens (Human) EV
Q8K3Z0 Nod2 Nucleotide-binding oligomerization domain-containing protein 2 Mus musculus (Mouse) EV
10 20 30 40 50 60
MCAQDAFQTQ RSQLVELLVS GSLEGFESIL DRLLSREVLS WEDYEGLSLV GQPISHLARR
70 80 90 100 110 120
LLDTIWNKGT WGCEQLTAAV REAQADSQPP ELPSSWDPHS PHPARDLQSH RPAIVRRLYG
130 140 150 160 170 180
HVEGVLDLTQ QRGFISQYET DEIRRPIFTS SQRARRLLDL ATVKANGLAA FLLQCIQELP
190 200 210 220 230 240
VPLALPFEDA ACKKYVSKLR TVISAQSRFL STYDGAENLC LEEVYTENVL EIQMEVGMAG
250 260 270 280 290 300
PSQQSPTTLG LEELFSTRDH FNKEADTVLV VGEAGSGKST LLQQLHLLWA SGRAFQEFLF
310 320 330 340 350 360
VFPFSCRQLQ CLVKPLSMRT LLFEHCCWPD LGPQDVFQVL LDHPERILLT FDGFDEFRFR
370 380 390 400 410 420
FTDQERHCCP TAPTSVQSLL FNLLQGNLLK NARKVLTSRP SAVSASLRKH VRTELSLKGF
430 440 450 460 470 480
SEEGIELYLR KRHREPGVAD RLLCLLRATS ALHGLCHLPV FSWMVSKCHE ELLLQGRGSP
490 500 510 520 530 540
KTTTDMYLLI LRHFLLHASP LPLATHGLGP SLIQGRLPTL LHLGRLALWG LGTCCYVFSA
550 560 570 580 590 600
KQLQAAHVDS EDLSLGFLVL AKRVVPGSTA PLEFLHITFQ CFFAAFYLAL SADTPPSSLR
610 620 630 640 650 660
HLFQDHRPES SPLARVLPKL FLRGSRCREG SVAALLQGAE PHNLQITGAF LAGLLSQEHR
670 680 690 700 710 720
SLLAECQASE TALLRRWDCV RRCLTRSLRE HFRSIPPALP GEAKSMHALP GFLWLIRSLY
730 740 750 760 770 780
EMQEERLARE AVCRLNVGHL KLTFCGVGPA ECAALAFVLR HLRRPVALQL DHNSVGDIGV
790 800 810 820 830 840
EQLLPCLGVC KALYLRDNNI SDRGICKLVE HALRCEQLQK LALFNNKLTD GCAHSMARLL
850 860 870 880 890 900
ACKQNFLALR LGNNHITAAG AEVLAQGLRT NNSLQFLGFW GNQVGDEGAQ ALAAALGDHQ
910 920 930 940 950 960
SLRWLSLVGN NIGSVGAQAL ALMLEKNMAL EELCLEENHV QDEGVCFLAK GLARNSSLKV
970 980 990 1000 1010
LKLSNNHISS LGAEALLRAL EKNDTILEVW LRGNTFSPEE IEKLSHQDTR LLL