Q6DHC1
Gene name |
rab18b (rab18, zgc:92523) |
Protein name |
Ras-related protein Rab-18-B |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:445055 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DHC1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DHC1-F1 | Predicted | AlphaFoldDB |
No variants for Q6DHC1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DHC1 | |||||
No associated diseases with Q6DHC1
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| chordate embryonic development | The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. |
| eye development | The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lipid droplet organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0IIG8 | RAB18 | Ras-related protein Rab-18 | Bos taurus (Bovine) | PR |
| Q5ZLG1 | RAB18 | Ras-related protein Rab-18 | Gallus gallus (Chicken) | PR |
| Q9NP72 | RAB18 | Ras-related protein Rab-18 | Homo sapiens (Human) | PR |
| P35293 | Rab18 | Ras-related protein Rab-18 | Mus musculus (Mouse) | PR |
| Q5EB77 | Rab18 | Ras-related protein Rab-18 | Rattus norvegicus (Rat) | PR |
| Q6TNS7 | rabl3 | Rab-like protein 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6IMK3 | dnajc27 | DnaJ homolog subfamily C member 27 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDDDVLTTLK | ILIIGESGVG | KSSLLLRFTD | DTFDPELAAT | IGVDFKVKTI | AIDGNRAKLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IWDTAGQERF | RTLTPSYYRG | AQGVILVYDV | TKRDTFTKLE | NWLNELETYC | TRNDLVKMLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GNKIDKDNRE | VDRNEGLKFA | RKHSMLFIEA | SAKTRDGVQC | AFEELVEKIL | QTPGLWESSI |
| 190 | 200 | ||||
| QNHGVQLSDN | EPQRQGACGG | YCSLV |