Q6DFS6

SS
Gene name
chmp2a (TNeu078g14.1)
Protein name
Charged multivesicular body protein 2a
Names
Chromatin-modifying protein 2a , CHMP2a
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:448496
EC number
Protein Class

Descriptions

CHMP2A is a core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. Removing 42 amino acids from the C-terminal of the protein unmasks a common ability to associate with endosomal membranes and assemble into large polymeric complexes, and the C-terminal sequences are also important for interaction of ESCRT-III protein with VPS4. Thus, ESCRT-III proteins cycle between a closed state and an activated open state is under control of sequences at the C-terminus and associated factors.

Autoinhibitory domains (AIDs)

181-220 (C-terminal α6 domain) SS

Target domain

1-144 (N-terminal α1-α4 domains)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DFS6

Entry ID Method Resolution Chain Position Source
AF-Q6DFS6-F1 Predicted AlphaFoldDB

No variants for Q6DFS6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DFS6

No associated diseases with Q6DFS6

1 regional properties for Q6DFS6

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 16 - 141 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
ESCRT III complex A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission).
late endosome membrane The lipid bilayer surrounding a late endosome.
multivesicular body A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
endosome transport via multivesicular body sorting pathway The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.
exit from mitosis The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
late endosome to vacuole transport The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.
nuclear membrane reassembly The reformation of the nuclear membranes following their breakdown in the context of a normal process.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZHN1 CHMP2A Charged multivesicular body protein 2a Gallus gallus (Chicken) SS
O43633 CHMP2A Charged multivesicular body protein 2a Homo sapiens (Human) EV
Q9DB34 Chmp2a Charged multivesicular body protein 2a Mus musculus (Mouse) SS
Q9SKI2 VPS2.1 Vacuolar protein sorting-associated protein 2 homolog 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q5BKM3 chmp3 Charged multivesicular body protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6DF27 chmp1b Charged multivesicular body protein 1b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q7ZW25 chmp2a Charged multivesicular body protein 2a Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEFLFGRRKT PEEMLRQNQR ALNKAMREMD RERQKLEQQE KKIIADIKKM AKQGQMDAVK
70 80 90 100 110 120
IMAKDLVRTR RYVKKFIMMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM ATMNRQLKLP
130 140 150 160 170 180
QIQKIMMEFE KQSEIMDMKE EMMNDAIDDA MGDEDDEEES DAVVSQVLDE LGLTLTDELS
190 200 210
NLPSTGGSLS VAGAKKGEPS AALADADADL EERLNNLRRD