Q6DE55

SS
Gene name
arhgap45
Protein name
Rho GTPase-activating protein 45
Names
Minor histocompatibility protein HA-1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:446507
EC number
Protein Class

Descriptions

ARHGAP45 contains a GTPase activator for the Rho-type GTPase (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. The N-terminal BAR domain of human ARHGAP45(Q92619) is autoinhibitory as ARHGAP45 mutants lacking this region, but not full-length ARHGAP45, show GAP activity towards RhoGTPases.

Autoinhibitory domains (AIDs)

261-524 (N-terminal BAR domain) SS

Target domain

670-1107 (C1-GAP-tail domains)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DE55

Entry ID Method Resolution Chain Position Source
AF-Q6DE55-F1 Predicted AlphaFoldDB

No variants for Q6DE55

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DE55

No associated diseases with Q6DE55

3 regional properties for Q6DE55

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 730 - 942 IPR000198
domain FCH domain 266 - 353 IPR001060
domain F-BAR domain 261 - 524 IPR031160

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, ruffle membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSRKKRELM KTPSLSKKSR AGSPAPQNDL TRKDVTDSSN DLASSPPSNS SPVSSGTLKR
70 80 90 100 110 120
PSSLSRHASA AGIPLSSPRG KATKPASTPS PPESGEGPFI DVEDISQLLG DVARFAERLE
130 140 150 160 170 180
KLRDVVQDEE LKETRRPLAH ECLGEALRLL RQVINKYPLL NTVETLTAAG TLISKVKGFH
190 200 210 220 230 240
YESSIENDKR DFEKALESMA VCFSSTISEF LMGEVDSSTL LSLPPGDQSQ SMESLCGGLS
250 260 270 280 290 300
GGEGALPSAH EYVEAGGHLG EDVDVILQRS DGGVQAALLY AKNMAKYLKD LSSYIEKRTI
310 320 330 340 350 360
LEMEYAKGLQ KLVNAYKGTL NQETHMPFQS IYSVALEQDL EHGHGILHTA LTLQHQTFLQ
370 380 390 400 410 420
PINMRRQEHE KRRKEVKEQW QRAQRKLMEA ESNLRKARQA YMQRSEEHER ALYNATRAEE
430 440 450 460 470 480
EQSHSGTRSL DKKRRAEEEA KNRAEEAMAT YRTCIADAKT QKQELEDVKV NVLRQLQELI
490 500 510 520 530 540
KQSDQILRSA TISYYQSMHM QTAPLPVGFQ MLCESSKLYD LGQQYASYVR QLGAVNEPET
550 560 570 580 590 600
SYDFQPYTPQ ITWSPCIRAR KSSFNSQDIP SSENKEISGE ERGVERRGGR GHQVHKSWPT
610 620 630 640 650 660
AITEGDPAVS SATVPAFPEK LHQPLSPTEN VDQKRLSASF EQSINGLSGS LEVQNSTGPF
670 680 690 700 710 720
RNIGLSRAAL THRLRKLRTP SKCRECNSYV YFQGAECEEC SLACHKKCLE TLAIQCGHKK
730 740 750 760 770 780
LQGRLLLFGR DFSETALRSP DHIPFLIRKC VSEIEERALI MKGIYRVNGV KTRVEKLCQA
790 800 810 820 830 840
FENGKELVEL SQASPHDLSN VLKLYLRQLP EPLIPFRLYN GLMGLAKESL RGTETGKGPR
850 860 870 880 890 900
LQDKGPNTET DVLSIVVQLK ELLQDLPSEN RTTLQYLVKH LCRVSEQEQL NKMSPSNLGI
910 920 930 940 950 960
VFGPALMRPR PTDATVSLSS LVDYPHQARI VETLIIFYST IFQEPVSNTD IGTGNSSSDD
970 980 990 1000 1010 1020
TASMQSRARL QVTVEEDLSE LTPEYQIPVF KEPGASTVES DSESDGAEDI PGTWKPQTTR
1030 1040 1050 1060 1070 1080
GHLTKEASVT SAEDIPYIEG EAQSESEEDR DQTQENLAEN NTNQSNNVAV NGHCCVPHFH
1090 1100
CHTQLPAIRM MHGKIYVSSA DRRPHFV