Q6BEA0
Gene name |
plxna4 |
Protein name |
Plexin-A4 |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:325938 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
1320-1873 (Plexin, cytoplasmic RasGAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
1320-1873 (Plexin, RasGAP domain) |
Relief mechanism |
|
Assay |
|
Target domain |
1320-1873 (Plexin, RasGAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Takahashi T et al. (2001) "Plexina1 autoinhibition by the plexin sema domain", Neuron, 29, 429-39
- He H et al. (2009) "Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration", Proceedings of the National Academy of Sciences of the United States of America, 106, 15610-5
- Wang Y et al. (2012) "Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization", Science signaling, 5, ra6
Autoinhibited structure
Activated structure
1 structures for Q6BEA0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6BEA0-F1 | Predicted | AlphaFoldDB |
No variants for Q6BEA0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6BEA0 | |||||
No associated diseases with Q6BEA0
15 regional properties for Q6BEA0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sema domain | 27 - 515 | IPR001627 |
| repeat | Plexin repeat | 518 - 566 | IPR002165-1 |
| repeat | Plexin repeat | 663 - 706 | IPR002165-2 |
| repeat | Plexin repeat | 812 - 863 | IPR002165-3 |
| domain | IPT domain | 865 - 959 | IPR002909-1 |
| domain | IPT domain | 961 - 1046 | IPR002909-2 |
| domain | IPT domain | 1048 - 1148 | IPR002909-3 |
| domain | IPT domain | 1150 - 1248 | IPR002909-4 |
| domain | Plexin, cytoplasmic RasGAP domain | 1320 - 1873 | IPR013548 |
| domain | PSI domain | 517 - 567 | IPR016201-1 |
| domain | PSI domain | 663 - 710 | IPR016201-2 |
| domain | PSI domain | 811 - 864 | IPR016201-3 |
| domain | Plexin, TIG domain 1 | 572 - 662 | IPR041019 |
| domain | Plexin, TIG domain 2 | 717 - 810 | IPR041362 |
| domain | Plexin, cytoplasmic RhoGTPase-binding domain | 1494 - 1606 | IPR046800 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| semaphorin receptor complex | A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| semaphorin receptor activity | Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonal defasciculation | Separation of axons away from a bundle of axons known as a fascicle. |
| morphogenesis of a branching structure | The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. |
| negative regulation of cell adhesion | Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. |
| positive regulation of axonogenesis | Any process that activates or increases the frequency, rate or extent of axonogenesis. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| semaphorin-plexin signaling pathway involved in axon guidance | Any semaphorin-plexin signaling pathway that is involved in axon guidance. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q769I5 | MET | Hepatocyte growth factor receptor | Bos taurus (Bovine) | PR |
| A0M8S8 | MET | Hepatocyte growth factor receptor | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| O43157 | PLXNB1 | Plexin-B1 | Homo sapiens (Human) | EV SS |
| O75051 | PLXNA2 | Plexin-A2 | Homo sapiens (Human) | SS |
| P51805 | PLXNA3 | Plexin-A3 | Homo sapiens (Human) | SS |
| Q9UIW2 | PLXNA1 | Plexin-A1 | Homo sapiens (Human) | EV SS |
| O15031 | PLXNB2 | Plexin-B2 | Homo sapiens (Human) | SS |
| Q9ULL4 | PLXNB3 | Plexin-B3 | Homo sapiens (Human) | SS |
| Q9HCM2 | PLXNA4 | Plexin-A4 | Homo sapiens (Human) | SS |
| Q9QY40 | Plxnb3 | Plexin-B3 | Mus musculus (Mouse) | SS |
| P70208 | Plxna3 | Plexin-A3 | Mus musculus (Mouse) | EV SS |
| Q3UH93 | Plxnd1 | Plexin-D1 | Mus musculus (Mouse) | SS |
| P70207 | Plxna2 | Plexin-A2 | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| B2RXS4 | Plxnb2 | Plexin-B2 | Mus musculus (Mouse) | SS |
| Q8CJH3 | Plxnb1 | Plexin-B1 | Mus musculus (Mouse) | SS |
| Q9QZC2 | Plxnc1 | Plexin-C1 | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| P70206 | Plxna1 | Plexin-A1 | Mus musculus (Mouse) | EV SS |
| Q80UG2 | Plxna4 | Plexin-A4 | Mus musculus (Mouse) | SS |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| D3ZPX4 | Plxna3 | Plexin-A3 | Rattus norvegicus (Rat) | SS |
| D3ZLH5 | Plxnb3 | Plexin-B3 | Rattus norvegicus (Rat) | SS |
| B0S5N4 | plxna3 | Plexin A3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFHNRRWNF | TFSCCVVVLL | LPLVAARPQQ | PSAATRVHEE | YSTFRVENTE | WTFNHLAVDH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RNGNVYLGAV | NRIYKLSPGL | DIQVSHQTGP | DEDNRNCYPP | RIVQPCSEPL | TLTNNVNKML |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LMDYRENRLL | ACGSLYQGIC | KLLRLDDLFK | LGEPFHKKEH | YLSGVNESGS | VFGVIVSYGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASPDKLFVAT | AVDGRPEYFP | TISSRKLTRN | SEEDGMFAYV | FHDEFVASMI | KIPSDTFTVV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PDFDIYYVYG | FSSGNFVYFL | TLQPEMGGGP | TTGSSSAGRE | QVYTSKLVRL | CKDDTAFNSY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEVPLGCVKG | GVEYRLLQAA | YLSKAGTILA | RSLGIGPDDD | ILYAVFSKGQ | KRRPKESSQE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SALCVFTLKE | INERIKDRLQ | SCYKGEGTLD | LAWLKVKDIS | CSSALLTIDD | NFCGLDMNAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LGVSEMVRGI | PLFSESKDKM | TSVIAYVYKN | HSLAFVGTRG | GRLKKIRVDG | PTYGALQYET |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IQVVDNGPIL | RDMAFSSDQH | FLYVMSESQL | TRVPVEACEQ | YSSCNECLGS | GDPHCGWCVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HSMCTRKEKC | ERSSEPRRFA | SNIKQCVRLS | VHPNNISVSQ | YSVMLVLEAH | NVPELSAGVN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CTFEDLAEMD | GLVEGNRITC | SSPAEKEVPR | IIVDQGDHQI | VQLYLKSKET | GLAFANTSFV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FYNCSVHKSC | LSCVGSPYQC | HWCKYRHTCT | HDPSSCSFQE | GRVKQPEECP | QLLPADRILV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PVNVVKPITL | RAKNLPQPQS | GQRGYECVLT | IQGVEQRVPA | LRFNSSSVQC | QNTSYMYDGM |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EMSSLPVDLT | VIWNGDFSID | NPAQNKVHLY | KCDARRESCG | LCLKADPLFG | CVWCKGENRC |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SLKQHCSYPQ | SMWLEHNGIN | SKCTHPRITK | ITPLRGPREG | GTLVTIRGEN | LGLEFSEIKD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HVKVADVECT | PVPEGYIPAE | QIVCEMGKAE | RSQFAGNVQV | CVGECRPEFM | AKSSKYYYFV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IPQLLSLKPS | RGPISGGTIV | NITGGNLDAG | SNVSIMFKDQ | KCTYQRRGGQ | WITCRSHASM |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| QGYGNVSVSV | YVDKAHIHKD | LKFEYVEDPT | ITKLEPEWSI | FSGNTPLTVS | GTNLDIIHTP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LIRAKYKNLE | TINICQVLSP | TTMQCMAPEL | PYSISKHKDV | PERPDEFGFI | LDNVQSVLAL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NNTNFVYYPN | PVFEPLSVSG | VQELKPGSPI | ILKGRNFLPP | TPGGNGKLNY | TVLIGDKPCA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LTVSDTQLLC | ESPNLTGRHK | VLARVGGIEF | SPGVVHITSD | SPLSSTAVIS | IAGAGGLLIF |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| FIVIVLIAYK | RKSRESDLTL | KRLQMQMDNL | ESRVALECKE | AFAELQTDIH | ELTSDLDGAG |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| IPFLDYRTYT | MRVLFPGIEE | HPVLRDLEVP | GYRQEQVEKG | LKLFGQLINN | KVFLLSFIRT |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LESQRGFSMR | DRGNVASLIM | TVLQSKLEYA | TDVLKHLLSD | LIDKNLESKN | HPKLLLRRTE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| SVAEKMLTNW | FTFLLYKFLK | ECAGEPLFSL | FCAIKQQMEK | GPIDSITGEA | RYSLSEDKLI |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| RQQIDYKTLV | VNCMHPDNEK | SPEVQVKVLN | CDTVSQVKEK | ILDAIYKNVP | YSHRPKASDM |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| DLEWRQGRVV | RVILQDEDVT | TKIEADWKRL | NMLSHYQVTD | NAVVALVPKQ | VTAYNSVNNS |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| TVSRTSASKY | ENMIKYTGSP | DSLRSRTPMI | TPDLESGVKV | WHLVKNHEHG | DQKEGDRGSK |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| MVSEIYLTRL | LATKGTLQKF | VDDLFETIFS | TAHRGSALPL | AIKYMFDFLD | EQADKHNIHD |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| PHVRHTWKSN | CLPLRFWVNV | IKNPQFVFDI | HKSSITDACL | SVVAQTFMDS | CSTSEHRLGK |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| DSPSNKLLYA | KDIPSYKSWV | ERYYSDISKM | PAISDQDMNA | YLAEQSRMHM | NEFNTMSSLS |
| 1870 | 1880 | 1890 | 1900 | ||
| EIYSYIGKYT | EEIVSALEQD | DGARKQRLAY | KLEQVVAFMS | LES |