Q6ATG6

PR
Gene name
Os05g0271300 (LOC_Os05g18850, OJ1653_D06.9, OSJNBb0061M13.3)
Protein name
Ribonuclease 3-like protein 2
Names
Ribonuclease III-like protein 2, RNase III-like protein 2
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6ATG6

Entry ID Method Resolution Chain Position Source
AF-Q6ATG6-F1 Predicted AlphaFoldDB

No variants for Q6ATG6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6ATG6

No associated diseases with Q6ATG6

2 regional properties for Q6ATG6

Type Name Position InterPro Accession
domain Ribonuclease III domain 37 - 208 IPR000999
domain Double-stranded RNA-binding domain 211 - 274 IPR014720

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ribonuclease III activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6TUI4 DICER1 Endoribonuclease Dicer Bos taurus (Bovine) SS
Q25BN1 DICER1 Endoribonuclease Dicer Gallus gallus (Chicken) SS
Q9UPY3 DICER1 Endoribonuclease Dicer Homo sapiens (Human) EV
Q8R418 Dicer1 Endoribonuclease Dicer Mus musculus (Mouse) SS
P34529 dcr-1 Endoribonuclease dcr-1 Caenorhabditis elegans PR
B3DLA6 dicer1 Endoribonuclease Dicer Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6TV19 dicer1 Endoribonuclease Dicer Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAPPPAMKPA SRKRGPPAPD PVELPPPGFV ADRAEAAARV ERLLRYQFRD GRLLEEALTH
70 80 90 100 110 120
QSFADDAVSY QRLEFVGDSA LGLAFSNFLY LTNPTLGPGP LSTLRAANIS TEKLARVAVR
130 140 150 160 170 180
HDLYPLLRRN CPRLDLLVGQ FIETVKQEPE DDLSTVPYGG SVVKAPKVLA DIVEAIAAAV
190 200 210 220 230 240
YVDCKFDLEK LWKVTRWLFE PIITAETIDE QPVTMLHELC QKHGKMAQFK TWQKGGMTVV
250 260 270 280 290 300
NVFVAGELVG IGSSEQKVIA KLNAARDATR KLAGAKKQVL TTGVGNGLGD EIGELRECKQ
310
KLNEQCSRQN WPKPIFK