AiPD: Autoinhibited Protein Database

Gene name	Morc2a
Protein name	ATPase MORC2A
Names	MORC family CW-type zinc finger protein 2A, Zinc finger CW-type coiled-coil domain protein 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74522
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

501-910 (Predicted disordered autoinhibitory region) PR

501-910 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q69ZX6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389125506	7	S>N	No	EVA
rs3389077389	31	G>D	No	EVA
rs3389138081	34	A>D	No	EVA
rs3389137870	90	R>K	No	EVA
rs3389140332	127	C>S	No	EVA
rs260009026	130	L>M	No	EVA
rs3389134059	131	S>Y	No	EVA
rs3389149659	134	F>I	No	EVA
rs3389125496	136	E>D	No	EVA
rs3389111223	167	I>F	No	EVA
rs3389077343	170	E>G	No	EVA
rs3389149733	185	M>V	No	EVA
rs3389148871	231	E>A	No	EVA
rs3389111301	235	P>T	No	EVA
rs3389140282	247	L>H	No	EVA
rs3389132035	266	R>G	No	EVA
rs3389132073	286	T>S	No	EVA
rs3389077405	332	L>M	No	EVA
rs3389136604	345	E>D	No	EVA
rs3389132013	400	Q>R	No	EVA
rs3389136847	457	A>G	No	EVA
rs3389140472	461	I>F	No	EVA
rs3401154557	481	S>C	No	EVA
rs3389136808	497	I>T	No	EVA
rs3389132005	509	P>L	No	EVA
rs3389132070	511	Q>H	No	EVA
rs3389114035	521	D>E	No	EVA
rs3401893164	521	D>N	No	EVA
rs3389077357	525	C>S	No	EVA
rs3401851740	541	Q>E	No	EVA
rs3401792505	550	L>F	No	EVA
rs3401774660	551	K>*	No	EVA
rs3401790381	553	D>A	No	EVA
rs3401893159	553	D>Y	No	EVA
rs3389136588	561	Q>*	No	EVA
rs3389140465	565	T>R	No	EVA
rs3389136865	577	A>T	No	EVA
rs258989344	637	S>T	No	EVA
rs3389150330	653	T>I	No	EVA
rs3389140463	654	T>I	No	EVA
rs3389114019	786	L>F	No	EVA
rs3389136835	791	K>E	No	EVA
rs3389144517	798	E>Q	No	EVA
rs3389131991	806	Y>F	No	EVA
rs3389114113	812	A>V	No	EVA
rs3389125442	836	R>K	No	EVA
rs3389140331	855	P>S	No	EVA
rs3401893187	901	P>L	No	EVA
rs3389140316	913	L>F	No	EVA
rs3389114044	922	P>H	No	EVA
rs3389111263	934	V>A	No	EVA
rs3389132012	1013	N>K	No	EVA
rs3389144463	1030	D>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Zinc finger, CW-type	490 - 544	IPR011124
domain	Morc, S5 domain 2-like	329 - 451	IPR041006

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm, cytosol Chromosome Nucleus matrix	Mainly located in the nucleus Upon phosphorylation at Ser-737, recruited to damaged chromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
heterochromatin	A compact and highly condensed form of chromatin that is refractory to transcription.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
identical protein binding	Binding to an identical protein or proteins.
magnesium ion binding	Binding to a magnesium (Mg) ion.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
chromatin remodeling	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
negative regulation of gene expression, epigenetic	An epigenetic process that silences gene expression at specific genomic regions through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA.
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.
positive regulation of DNA methylation-dependent heterochromatin assembly	Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q14149	MORC3	MORC family CW-type zinc finger protein 3	Homo sapiens (Human)	EV
Q8TE76	MORC4	MORC family CW-type zinc finger protein 4	Homo sapiens (Human)	SS
Q9Y6X9	MORC2	ATPase MORC2	Homo sapiens (Human)	PR
F7BJB9	Morc3	MORC family CW-type zinc finger protein 3	Mus musculus (Mouse)	SS
Q8BMD7	Morc4	MORC family CW-type zinc finger protein 4	Mus musculus (Mouse)	SS
Q8C5W4	Morc2b	ATPase MORC2B	Mus musculus (Mouse)	PR