Q67E00
Gene name |
dstyk (ripk5) |
Protein name |
Dual serine/threonine and tyrosine protein kinase |
Names |
Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:493205 |
EC number |
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
785-805 (Activation loop from InterPro)
Target domain |
643-897 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q67E00
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q67E00-F1 | Predicted | AlphaFoldDB |
No variants for Q67E00
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q67E00 | |||||
No associated diseases with Q67E00
4 regional properties for Q67E00
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 643 - 897 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 645 - 892 | IPR001245 |
| active_site | Serine/threonine-protein kinase, active site | 764 - 776 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 649 - 672 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.12.1 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to fibroblast growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. |
| embryonic organ development | Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of fibroblast growth factor receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VDU3 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Bos taurus (Bovine) | SS |
| Q3SZJ2 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Bos taurus (Bovine) | PR |
| Q4TVR5 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Bos taurus (Bovine) | PR |
| Q6XUX0 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Gallus gallus (Chicken) | PR |
| P83104 | Takl1 | Putative mitogen-activated protein kinase kinase kinase 7-like | Drosophila melanogaster (Fruit fly) | PR |
| Q95UN8 | slpr | Mitogen-activated protein kinase kinase kinase | Drosophila melanogaster (Fruit fly) | EV |
| O43353 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Homo sapiens (Human) | PR |
| Q02779 | MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 | Homo sapiens (Human) | SS |
| Q8NB16 | MLKL | Mixed lineage kinase domain-like protein | Homo sapiens (Human) | EV |
| Q16584 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | Homo sapiens (Human) | EV |
| P00540 | MOS | Proto-oncogene serine/threonine-protein kinase mos | Homo sapiens (Human) | PR |
| Q5TCX8 | MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 | Homo sapiens (Human) | PR |
| O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (Human) | SS |
| Q9NYL2 | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20 | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| P80192 | MAP3K9 | Mitogen-activated protein kinase kinase kinase 9 | Homo sapiens (Human) | SS |
| Q6XUX3 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Homo sapiens (Human) | PR |
| Q80XI6 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Mus musculus (Mouse) | PR |
| Q8VDG6 | Map3k21 | Mitogen-activated protein kinase kinase kinase 21 | Mus musculus (Mouse) | PR |
| P58801 | Ripk2 | Receptor-interacting serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q62073 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Mus musculus (Mouse) | EV |
| Q3U1V8 | Map3k9 | Mitogen-activated protein kinase kinase kinase 9 | Mus musculus (Mouse) | SS |
| Q9D2Y4 | Mlkl | Mixed lineage kinase domain-like protein | Mus musculus (Mouse) | SS |
| Q9ESL4 | Map3k20 | Mitogen-activated protein kinase kinase kinase 20 | Mus musculus (Mouse) | PR |
| P00536 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Mus musculus (Mouse) | PR |
| Q66L42 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Mus musculus (Mouse) | SS |
| P0C8E4 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Rattus norvegicus (Rat) | SS |
| Q66HA1 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Rattus norvegicus (Rat) | PR |
| D3ZG83 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Rattus norvegicus (Rat) | SS |
| P00539 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9FPR3 | EDR1 | Serine/threonine-protein kinase EDR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q05609 | CTR1 | Serine/threonine-protein kinase CTR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQKDGTRSSR | RMEEGDRRNG | STGSSGSVSR | ELGRGFSYYN | KYLARLQQNL | RDTKRFFRDI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHTYSGAPGG | PDTDIKGAEG | DLGQLHSITF | PRQEEEYLKL | TVRCRPCIFI | LGQSCSSRGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VANSLLGDQL | LPILTHCGSE | CCKRRRIRFR | YGKQTLVSLA | LPEQYELVHE | LVAHQGKWDT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IPEEDLDVPE | DEEDPAHRLA | ELEVTLPHQL | LQDVDIVVSP | CRSSQAVSMT | LEDYVDHVQS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVVYAVCEER | LSQQDEEELT | EIKEKYKLPV | FFIRTSSTRD | RLIGGSEGVR | SALYEQLMEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GFLKRGLCNC | GAAGSGSTAP | SMLVEQFEKL | RQVSTFSRQV | LQMHLVDAAI | VLNMVHSRCL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DLFINKAFDM | HRDLQITPKR | LEYTRQKENE | LYESLMRISD | RKQEELKDMI | VETLNSMREQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLEDAANMQF | KDIAIPQNGE | PVSVQEVKCC | IFQIKELIIS | RLNQAVVNKL | ISSVDYLRES |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FVGTLERCLR | SLEKSQQESS | SHVTSNHLKQ | ILNAAYHVEV | TFNSGSTVTR | MVWEQIVQII |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QRITWVSPPT | ITPEWKRRVA | QDAIESLSAS | KLAKSICSQF | CKRLKSSHEA | FAASLKQLEV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GHSGRLEKTN | DLWLRVRKDH | APRLARLSLE | SRSLQDVLLH | GKPRIGRELG | RGQYGVVYLC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DSWGGHFPCA | LKSVVPPDEK | HWNDLALEFH | YMRSLPKHER | LVDLHGSVID | YSYGGGSSIA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VLLITERLHR | DLYVGLKTGL | SLETRLQIAL | DVVEGIRFLH | NQGLVHRDIK | LKNVLLDKKH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RAKITDLGFC | KPEAMMSGSI | VGTPIHMAPE | LFSGKYDNSV | DVYAFGILFW | YICSGSVKLP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EAFEKCASKD | HLWNNVRKGA | RPERLAIFDE | ECWKLMEACW | NGDPSQRPLM | GIVQPMLQGI |
| 910 | |||||
| MDRLCRAQET | GKALEDST |