Q66X01

PR
Gene name
Nlrp9c (Nalp9c)
Protein name
NACHT, LRR and PYD domains-containing protein 9C
Names
NALP-zeta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:330490
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q66X01

Entry ID Method Resolution Chain Position Source
AF-Q66X01-F1 Predicted AlphaFoldDB

88 variants for Q66X01

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388870469 27 L>H No EVA
rs245274055 32 Q>P No EVA
rs258573300 55 T>M No EVA
rs3388870407 75 Q>H No EVA
rs3388883160 109 T>S No EVA
rs3388892579 113 N>D No EVA
rs16790590 123 T>I No EVA
rs16790590 123 T>N No EVA
rs3388888505 159 L>* No EVA
rs234972737 165 D>N No EVA
rs261219695 177 Q>R No EVA
rs3388888596 181 F>V No EVA
rs3388883119 182 F>I No EVA
rs3388888698 195 L>S No EVA
rs3388873509 197 E>K No EVA
rs3388883172 210 L>M No EVA
rs16790584 218 K>T No EVA
rs222344053 222 F>I No EVA
rs3397679226 252 N>I No EVA
rs3397658262 253 V>I No EVA
rs3397742102 256 S>N No EVA
rs3397689260 256 S>R No EVA
rs3388849741 263 L>F No EVA
rs3388864579 271 E>D No EVA
rs3388888780 276 S>I No EVA
rs16790585 278 S>P No EVA
rs3388888508 298 Q>L No EVA
rs3388895976 305 V>E No EVA
rs16790586 324 E>G No EVA
rs16790587 334 S>T No EVA
rs3388893495 347 H>D No EVA
rs16790588 347 H>Q No EVA
rs3388882984 358 E>K No EVA
rs3388878867 371 A>S No EVA
rs3388890832 380 S>L No EVA
rs3388883139 404 Y>C No EVA
rs3388870428 410 D>N No EVA
rs3388888706 418 E>D No EVA
rs3388890864 487 A>T No EVA
rs3388878932 491 F>L No EVA
rs16790580 501 T>A No EVA
rs16790581 515 I>V No EVA
rs3388881267 517 Q>H No EVA
rs3388891371 525 S>G No EVA
rs3388888531 533 E>D No EVA
rs3388888537 541 L>F No EVA
rs16790582 542 F>L No EVA
rs16790583 546 I>V No EVA
rs3388888774 587 L>S No EVA
rs234980939 589 N>T No EVA
rs37282684 621 A>V No EVA
rs3388888781 646 K>R No EVA
rs3388893438 653 C>S No EVA
rs221830072 661 N>T No EVA
rs3388892596 690 L>R No EVA
rs16790595 723 R>G No EVA
rs38573551 742 M>I No EVA
rs3388849780 746 L>F No EVA
rs37239843 747 I>V No EVA
rs3397708282 754 L>H No EVA
rs3397851501 756 L>F No EVA
rs3397708226 761 L>F No EVA
rs3397296172 764 K>Q No EVA
rs3396914780 765 G>* No EVA
rs3388849787 771 K>E No EVA
rs217797579 797 H>Y No EVA
rs3388883108 816 N>I No EVA
rs254461538 833 P>S No EVA
rs16790682 857 A>T No EVA
rs3397618743 881 K>T No EVA
rs16790669 882 R>W No EVA
rs3396914770 884 C>* No EVA
rs3388883173 884 C>Y No EVA
rs3388886251 888 C>S No EVA
rs3397742009 890 P>H No EVA
rs3397851498 891 K>N No EVA
rs3396914806 892 C>R No EVA
rs3397679231 893 K>* No EVA
rs16790671 894 V>L No EVA
rs3388890838 904 L>H No EVA
rs38159347 906 N>S No EVA
rs3388895932 915 A>S No EVA
rs16790660 921 T>P No EVA
rs3388890828 925 L>F No EVA
rs3388864528 938 V>A No EVA
rs3388878870 973 E>K No EVA
rs3388891298 981 V>G No EVA
rs38180668 992 K>E No EVA

No associated diseases with Q66X01

8 regional properties for Q66X01

Type Name Position InterPro Accession
domain Protein kinase domain 186 - 444 IPR000719
domain EF-hand domain 487 - 558 IPR002048-1
domain EF-hand domain 559 - 628 IPR002048-2
active_site Serine/threonine-protein kinase, active site 306 - 318 IPR008271
binding_site Protein kinase, ATP binding site 192 - 215 IPR017441
binding_site EF-Hand 1, calcium-binding site 500 - 512 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 536 - 548 IPR018247-2
binding_site EF-Hand 1, calcium-binding site 606 - 618 IPR018247-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
inflammasome complex A cytosolic protein complex that is capable of activating caspase-1.

1 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

4 GO annotations of biological process

Name Definition
blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8CCN1 Nlrp10 NACHT, LRR and PYD domains-containing protein 10 Mus musculus (Mouse) PR
Q8R4B8 Nlrp3 NACHT, LRR and PYD domains-containing protein 3 Mus musculus (Mouse) SS
E9Q5R7 Nlrp12 NACHT, LRR and PYD domains-containing protein 12 Mus musculus (Mouse) SS
10 20 30 40 50 60
MVDSSSYGLL QYFQKLSDEE FQRFKELLQK EQEKFKLKPL SWTKIKNTSK EDLVTQLYTH
70 80 90 100 110 120
YPRQVWDMVL NLFLQVNRKD LSTMAQIERR DKQNKYKEFM KNLFQYIWTS ETNTYMPDRS
130 140 150 160 170 180
YNTIIDRQYK ALLDIFDSES DPATAVVLGT RGKGKTVFLR KAMLDWASGV LLQNRFQYVF
190 200 210 220 230 240
FFSVFSLNNT TELSLAELIS SKLPECSETL DDILSNPKRI LFVLDGFDYL KFDLELRTNL
250 260 270 280 290 300
CNDWRKRLPT QNVLSSLLQK IMLPECSLLL ELGESSCSKI IPLLQNPREI IMSGLSEQSI
310 320 330 340 350 360
YFYCVSFFKI QLGVEVFKDL KKNEPLFTLC SNPSMLWMIC SSLMWGHYSR EEVISSSEST
370 380 390 400 410 420
SAIHTIFIMS AFKSIFGLGS SKYKRFKLKT LCTLAVEGMW KQVYVFDSED LRRNKISESD
430 440 450 460 470 480
KTVWLKMKFL QIQGNNIMFY HSTLQWYFAT LFYFLKQDKD TYHPVIGSLP QLLGEIYAHK
490 500 510 520 530 540
QNQWTHAQTF FFGIATKHVI TLLKPCFGNI SFKTIRQEII RYLKSLSQPE CNEKLVHPKK
550 560 570 580 590 600
LFFCLIENQE ERFVSQVMNL FEEITVDISD SDDLGAAEYS LLRASKLKNL HLHIQKKVFS
610 620 630 640 650 660
EIHDPEYGSL ENFKLDQKFS AINWTMLSIL FCNLHVLDLG SCHFNKKVIE VLCNSLSPTP
670 680 690 700 710 720
NMPLTVFKLQ RLLCSFMTNF GDGSLFCTFL QIPQLKYLNL YGTDLSNDVV EMLCSALKCS
730 740 750 760 770 780
TCRVEELLLG KCDISSEACG IMATFLINSK VKHLSLVENP LKNKGVMFLC KMLKDPSCVL
790 800 810 820 830 840
ESLMLSYCCL TFIACGHLYE ALLSNKHLSL LDLGSNFLED IGVNLLCEAL KYPNCTLKEL
850 860 870 880 890 900
WLPGCYLTSE CCEEISAVLT CNKNLKTLKL GNNNIQDTGV KRLCEALCHP KCKVQCLGLD
910 920 930 940 950 960
MCELSNDCCE DLALALITCN TLKSLNLDWN ALHHSGLVML CEALNHKKCK LNMLGLDKSS
970 980 990 1000
FSEESQTFLQ AVEKKNNNLN VLHFPWVEDE LKKRGVRLVW NSKN