Q66JF1

SS
Gene name
sox11
Protein name
Transcription factor Sox-11
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:493415
EC number
Protein Class

Descriptions

Sox11 acts as a transcriptional activator of TEAD2 by binding to its gene promoter. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').

Autoinhibitory domains (AIDs)

202-213 (D/E repeat) SS

Target domain

37-128 (HMG box domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q66JF1

Entry ID Method Resolution Chain Position Source
AF-Q66JF1-F1 Predicted AlphaFoldDB

No variants for Q66JF1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q66JF1

No associated diseases with Q66JF1

1 regional properties for Q66JF1

Type Name Position InterPro Accession
domain Ubiquitin system component CUE 296 - 338 IPR003892

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

4 GO annotations of biological process

Name Definition
anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48435 SOX11 Transcription factor SOX-11 Gallus gallus (Chicken) SS
P35716 SOX11 Transcription factor SOX-11 Homo sapiens (Human) EV
Q7M6Y2 Sox11 Transcription factor SOX-11 Mus musculus (Mouse) SS
P0C1G9 Sox11 Transcription factor SOX-11 Rattus norvegicus (Rat) SS
Q8T3B9 sem-2 Transcription factor sem-2 Caenorhabditis elegans SS
Q6GLH8 sox17b.2 Transcription factor Sox-17-beta.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q8AWH2 sox17b.1 Transcription factor Sox-17-beta.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MVQQADSLDM DSSQHTEPDT EEGEFMACSP VALDESDPDW CKTATGHIKR PMNAFMVWSK
70 80 90 100 110 120
IERRKIMEQS PDMHNAEISK RLGKRWKMLN DSEKIPFIRE AERLRLKHMA DYPDYKYRPR
130 140 150 160 170 180
KKPKVDPSAS KPASLAQSPE KSPKSRSAGK KCPKLKPGSH SGSSSSSGSA KSLTIKSEYG
190 200 210 220 230 240
GDDYVFGSPK AASKAAKCVF MDEDDEEEEE DEEEDELQIR IKQEEEDEPL RQYNVAKVPA
250 260 270 280 290 300
SPTLSSSSAE SAEGASMYED VRNGTRLYYN FKNITKQSTI PQATITLAPA PRSAGTTSPS
310 320 330 340 350 360
SHKDELMFDL SLNFTQQNPP VPELGNPNSG NLSLSLVDKD LDSCSEGSLG SHFDFPDYCT
370 380
PELSEMIAGD WLEANFSDLV FTY