Q66IH9

PR
Gene name
zcchc4
Protein name
rRNA N6-adenosine-methyltransferase ZCCHC4
Names
Zinc finger CCHC domain-containing protein 4
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:493496
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

44-117 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q66IH9

Entry ID Method Resolution Chain Position Source
AF-Q66IH9-F1 Predicted AlphaFoldDB

No variants for Q66IH9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q66IH9

No associated diseases with Q66IH9

2 regional properties for Q66IH9

Type Name Position InterPro Accession
conserved_site DNA methylase, N-6 adenine-specific, conserved site 261 - 267 IPR002052
domain Zinc finger, GRF-type 26 - 70 IPR010666

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Accumulates in the nucleolus, where ribosome biogenesis takes place
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
nucleic acid binding Binding to a nucleic acid.
rRNA (adenine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine.
S-adenosyl-L-methionine binding Binding to S-adenosyl-L-methionine.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1BGQ2 ZCCHC4 rRNA N6-adenosine-methyltransferase ZCCHC4 Bos taurus (Bovine) PR
Q9H5U6 ZCCHC4 rRNA N6-adenosine-methyltransferase ZCCHC4 Homo sapiens (Human) PR
D3ZV31 Zcchc4 rRNA N6-adenosine-methyltransferase ZCCHC4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEGAEGSDSC DGIQVLLSRE VIDAAPQCPH GPTLLFVKVS QGKEQGRRFY ACSACRDRKD
70 80 90 100 110 120
CHFFQWEDDK VSQARLAARE EYNKSHQPPM THAQYVGRFQ EFTELPLAKR KFCSDCQQLL
130 140 150 160 170 180
LPTNWESHSG HRVLGDISLS QLKRPSQLLH PLENKKANAQ YLFAERSCTF LMDTIIALGF
190 200 210 220 230 240
RRVLCVGTPR LHELIKLRAC EGATPPIKSL LLDIDFRYSQ FYWEEEFCHY NMFNHHFFGG
250 260 270 280 290 300
EAAKMVCQKF LQEEDGKGAL LVTDPPFGGL VEPLAFSFKR LREMWKTTNP ENESNLPILW
310 320 330 340 350 360
MFPYFFESRI LQCFPDFTML DYQVDYDNHA LYKHGKTGRK QSPVRIFTDL PPDKIVLPAI
370 380 390 400 410 420
EGYRFCSVCE RFVCSGNKHC NICNCCTSKD GRPWKHCTQC NKCVKPSWTH CSACNHCALP
430 440 450 460 470 480
DHPCGTAGRG CFLCGGKDHK RRGCPHQSVS AHGKRMENLK QKNIKGSMKK QPIAATSKKR
KRKRNNP