Q66HE7
Gene name |
Cdkl1 |
Protein name |
Cyclin-dependent kinase-like 1 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:314198 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
143-166 (Activation loop from InterPro)
Target domain |
4-287 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

1 structures for Q66HE7
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q66HE7-F1 | Predicted | AlphaFoldDB |
No variants for Q66HE7
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
No variants for Q66HE7 |
No associated diseases with Q66HE7
Functions
Description | ||
---|---|---|
EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
3 GO annotations of cellular component
Name | Definition |
---|---|
ciliary transition zone | A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. |
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
3 GO annotations of biological process
Name | Definition |
---|---|
heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
protein phosphorylation | The process of introducing a phosphate group on to a protein. |
regulation of cilium assembly | Any process that modulates the frequency, rate or extent of cilium assembly. |
14 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q5MAI5 | CDKL4 | Cyclin-dependent kinase-like 4 | Homo sapiens (Human) | PR |
Q00532 | CDKL1 | Cyclin-dependent kinase-like 1 | Homo sapiens (Human) | PR |
Q92772 | CDKL2 | Cyclin-dependent kinase-like 2 | Homo sapiens (Human) | PR |
Q3TZA2 | Cdkl4 | Cyclin-dependent kinase-like 4 | Mus musculus (Mouse) | PR |
Q8BLF2 | Cdkl3 | Cyclin-dependent kinase-like 3 | Mus musculus (Mouse) | PR |
Q9QUK0 | Cdkl2 | Cyclin-dependent kinase-like 2 | Mus musculus (Mouse) | PR |
Q8CEQ0 | Cdkl1 | Cyclin-dependent kinase-like 1 | Mus musculus (Mouse) | PR |
Q5XIT0 | Cdkl2 | Cyclin-dependent kinase-like 2 | Rattus norvegicus (Rat) | PR |
Q4KM47 | Cdk10 | Cyclin-dependent kinase 10 | Rattus norvegicus (Rat) | PR |
Q641Z4 | Cdk9 | Cyclin-dependent kinase 9 | Rattus norvegicus (Rat) | PR |
Q4KM34 | Cdk20 | Cyclin-dependent kinase 20 | Rattus norvegicus (Rat) | PR |
O35831 | Cdk17 | Cyclin-dependent kinase 17 | Rattus norvegicus (Rat) | PR |
Q9JM01 | Cdkl3 | Cyclin-dependent kinase-like 3 | Rattus norvegicus (Rat) | PR |
Q6AXJ9 | cdkl1 | Cyclin-dependent kinase-like 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MEKYEKIGKI | GEGSYGVVFK | CRNRDTGQIV | AIKRFLETED | DPVIKKIALR | EIRMLKQLKH |
70 | 80 | 90 | 100 | 110 | 120 |
PNLVSLLEVF | RRKRRLHLVF | EYCHHTVLHE | LDRYQRGVPE | PLVKNITWQT | LQAVNFCHKH |
130 | 140 | 150 | 160 | 170 | 180 |
NCIHRDVKPE | NILITKHSVI | KLCDFGFARL | LTGPGDYYTD | YVATRWYRSP | ELLVGDTQYG |
190 | 200 | 210 | 220 | 230 | 240 |
PPVDVWAIGC | VFAELLSGVP | LWPGKSDVDQ | LYLIRKTLGD | LIPRHQQVFS | MNQYFSGVKI |
250 | 260 | 270 | 280 | 290 | 300 |
PDPEDMETLE | LKFPNISYSA | LGFLKGCLHM | DPAERLTCEQ | LLQHPYFDSI | RDVGELARPH |
310 | 320 | 330 | 340 | 350 | |
DKPTRKTLRQ | SRKHLTGLQH | LPQLTSSSVL | PALDRKKYHC | GTRNFNYHFP | NI |