Q66HE7

PR
Gene name
Cdkl1
Protein name
Cyclin-dependent kinase-like 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:314198
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

210-352 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

143-166 (Activation loop from InterPro)

Target domain

4-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q66HE7

Entry ID Method Resolution Chain Position Source
AF-Q66HE7-F1 Predicted AlphaFoldDB

No variants for Q66HE7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q66HE7

No associated diseases with Q66HE7

3 regional properties for Q66HE7

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 287 IPR000719
active_site Serine/threonine-protein kinase, active site 122 - 134 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
ciliary transition zone A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

3 GO annotations of biological process

Name Definition
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cilium assembly Any process that modulates the frequency, rate or extent of cilium assembly.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5MAI5 CDKL4 Cyclin-dependent kinase-like 4 Homo sapiens (Human) PR
Q00532 CDKL1 Cyclin-dependent kinase-like 1 Homo sapiens (Human) PR
Q92772 CDKL2 Cyclin-dependent kinase-like 2 Homo sapiens (Human) PR
Q3TZA2 Cdkl4 Cyclin-dependent kinase-like 4 Mus musculus (Mouse) PR
Q8BLF2 Cdkl3 Cyclin-dependent kinase-like 3 Mus musculus (Mouse) PR
Q9QUK0 Cdkl2 Cyclin-dependent kinase-like 2 Mus musculus (Mouse) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q5XIT0 Cdkl2 Cyclin-dependent kinase-like 2 Rattus norvegicus (Rat) PR
Q4KM47 Cdk10 Cyclin-dependent kinase 10 Rattus norvegicus (Rat) PR
Q641Z4 Cdk9 Cyclin-dependent kinase 9 Rattus norvegicus (Rat) PR
Q4KM34 Cdk20 Cyclin-dependent kinase 20 Rattus norvegicus (Rat) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q9JM01 Cdkl3 Cyclin-dependent kinase-like 3 Rattus norvegicus (Rat) PR
Q6AXJ9 cdkl1 Cyclin-dependent kinase-like 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKRFLETED DPVIKKIALR EIRMLKQLKH
70 80 90 100 110 120
PNLVSLLEVF RRKRRLHLVF EYCHHTVLHE LDRYQRGVPE PLVKNITWQT LQAVNFCHKH
130 140 150 160 170 180
NCIHRDVKPE NILITKHSVI KLCDFGFARL LTGPGDYYTD YVATRWYRSP ELLVGDTQYG
190 200 210 220 230 240
PPVDVWAIGC VFAELLSGVP LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS MNQYFSGVKI
250 260 270 280 290 300
PDPEDMETLE LKFPNISYSA LGFLKGCLHM DPAERLTCEQ LLQHPYFDSI RDVGELARPH
310 320 330 340 350
DKPTRKTLRQ SRKHLTGLQH LPQLTSSSVL PALDRKKYHC GTRNFNYHFP NI