Q64617
Gene name |
Prkch (Pkch) |
Protein name |
Protein kinase C eta type |
Names |
PKC-L, nPKC-eta |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:81749 |
EC number |
2.7.11.13: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
496-519 (Activation loop from InterPro)
Target domain |
359-681 (Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q64617
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q64617-F1 | Predicted | AlphaFoldDB |
No variants for Q64617
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q64617 | |||||
No associated diseases with Q64617
3 regional properties for Q64617
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 6 - 13 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 194 - 207 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 332 - 346 | IPR018181-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.13 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium-dependent protein kinase C activity | Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| calcium-independent protein kinase C activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| metal ion binding | Binding to a metal ion. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| small GTPase binding | Binding to a small monomeric GTPase. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of glial cell apoptotic process | Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of B cell receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. |
| positive regulation of glial cell proliferation | Any process that activates or increases the rate or extent of glial cell proliferation. |
| positive regulation of keratinocyte differentiation | Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. |
| positive regulation of macrophage derived foam cell differentiation | Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| protein kinase C signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of bicellular tight junction assembly | Any process that modulates the frequency, rate or extent of tight junction assembly. |
44 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P24583 | PKC1 | Protein kinase C-like 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| A1A4I4 | PKN1 | Serine/threonine-protein kinase N1 | Bos taurus (Bovine) | SS |
| P05126 | PRKCB | Protein kinase C beta type | Bos taurus (Bovine) | SS |
| A1Z7T0 | Pkn | Serine/threonine-protein kinase N | Drosophila melanogaster (Fruit fly) | SS |
| P83099 | Pkcdelta | Putative protein kinase C delta type homolog | Drosophila melanogaster (Fruit fly) | PR |
| P05130 | Pkc53E | Protein kinase C, brain isozyme | Drosophila melanogaster (Fruit fly) | SS |
| P13677 | inaC | Protein kinase C, eye isozyme | Drosophila melanogaster (Fruit fly) | SS |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| Q6P5Z2 | PKN3 | Serine/threonine-protein kinase N3 | Homo sapiens (Human) | SS |
| Q96LW2 | RSKR | Ribosomal protein S6 kinase-related protein | Homo sapiens (Human) | PR |
| Q16512 | PKN1 | Serine/threonine-protein kinase N1 | Homo sapiens (Human) | EV |
| Q16513 | PKN2 | Serine/threonine-protein kinase N2 | Homo sapiens (Human) | EV |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| P05129 | PRKCG | Protein kinase C gamma type | Homo sapiens (Human) | SS |
| P17252 | PRKCA | Protein kinase C alpha type | Homo sapiens (Human) | EV |
| P05771 | PRKCB | Protein kinase C beta type | Homo sapiens (Human) | SS |
| P70268 | Pkn1 | Serine/threonine-protein kinase N1 | Mus musculus (Mouse) | SS |
| Q02111 | Prkcq | Protein kinase C theta type | Mus musculus (Mouse) | PR |
| Q8BWW9 | Pkn2 | Serine/threonine-protein kinase N2 | Mus musculus (Mouse) | SS |
| Q8K045 | Pkn3 | Serine/threonine-protein kinase N3 | Mus musculus (Mouse) | SS |
| P28867 | Prkcd | Protein kinase C delta type | Mus musculus (Mouse) | PR |
| P16054 | Prkce | Protein kinase C epsilon type | Mus musculus (Mouse) | PR |
| P23298 | Prkch | Protein kinase C eta type | Mus musculus (Mouse) | PR |
| P63318 | Prkcg | Protein kinase C gamma type | Mus musculus (Mouse) | SS |
| P68404 | Prkcb | Protein kinase C beta type | Mus musculus (Mouse) | SS |
| Q63433 | Pkn1 | Serine/threonine-protein kinase N1 | Rattus norvegicus (Rat) | SS |
| O55173 | Pdpk1 | 3-phosphoinositide-dependent protein kinase 1 | Rattus norvegicus (Rat) | SS |
| P09217 | Prkcz | Protein kinase C zeta type | Rattus norvegicus (Rat) | SS |
| F1M7Y5 | Prkci | Protein kinase C iota type | Rattus norvegicus (Rat) | SS |
| P09215 | Prkcd | Protein kinase C delta type | Rattus norvegicus (Rat) | PR |
| P63319 | Prkcg | Protein kinase C gamma type | Rattus norvegicus (Rat) | SS |
| P47197 | Akt2 | RAC-beta serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| P47196 | Akt1 | RAC-alpha serine/threonine-protein kinase | Rattus norvegicus (Rat) | PR |
| Q63484 | Akt3 | RAC-gamma serine/threonine-protein kinase | Rattus norvegicus (Rat) | PR |
| O08874 | Pkn2 | Serine/threonine-protein kinase N2 | Rattus norvegicus (Rat) | SS |
| P09216 | Prkce | Protein kinase C epsilon type | Rattus norvegicus (Rat) | PR |
| P05696 | Prkca | Protein kinase C alpha type | Rattus norvegicus (Rat) | SS |
| P68403 | Prkcb | Protein kinase C beta type | Rattus norvegicus (Rat) | SS |
| P34722 | tpa-1 | Protein kinase C-like 1 | Caenorhabditis elegans | PR |
| P90980 | pkc-2 | Protein kinase C-like 2 | Caenorhabditis elegans | SS |
| A7MBL8 | pkn2 | Serine/threonine-protein kinase N2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY24 | prkcbb | Protein kinase C beta type | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSGTMKFNG | YLRVRIGEAV | GLQPTRWSLR | HSLFKKGHQL | LDPYLTVSVD | QVRVGQTSTK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QKTNKPTYNE | EFCTNVSDGG | HLELAVFHET | PLGYDHFVAN | CTLQFQELLR | TAGTSDTFEG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WVDLEPEGKV | FVVITLTGSF | TEATLQRDRI | FKHFTRKRQR | AMRRRVHQVN | GHKFMATYLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QPTYCSHCRE | FIWGVFGKQG | YQCQVCTCVV | HKRCHHLIVT | ACTCQNNINK | VDAKIAEQRF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GINIPHKFNV | HNYKVPTFCD | HCGSLLWGIM | RQGLQCKICK | MNVHIRCQAN | VAPNCGVNAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELAKTLAGMG | LQPGNISPTS | KLISRSTLRR | QGKEGSKEGN | GIGVNSSSRF | GIDNFEFIRV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGKGSFGKVM | LARIKETGEL | YAVKVLKKDV | ILQDDDVECT | MTEKRILSLA | RNHPFLTQLF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CCFQTPDRLF | FVMEFVNGGD | LMFHIQKSRR | FDEARARFYA | AEIISALMFL | HEKGIIYRDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLDNVLLDHE | GHCKLADFGM | CKEGICNGVT | TATFCGTPDY | IAPEILQEML | YGPAVDWWAM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GVLLYEMLCG | HAPFEAENED | DLFEAILNDE | VVYPTWLHED | ATGILKSFMT | KNPTMRLGSL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TQGGEHEILR | HPFFKEIDWV | QLNHRQLEPP | FRPRIKSRED | VSNFDPDFIK | EEPVLTPIDE |
| 670 | 680 | ||||
| GHLPMINQDE | FRNFSYVSPE | LQP |