Q64595
Gene name |
Prkg2 |
Protein name |
cGMP-dependent protein kinase 2 |
Names |
cGK 2, cGK2, cGMP-dependent protein kinase II, cGKII |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25523 |
EC number |
2.7.11.12: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
593-615 (Activation loop from InterPro)
Target domain |
453-711 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
2 structures for Q64595
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4OJK | X-ray | 266 A | C/D | 40-83 | PDB |
| AF-Q64595-F1 | Predicted | AlphaFoldDB |
2 variants for Q64595
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3322168594 | 195 | I>V | No | EVA | |
| rs3322375027 | 196 | V>I | No | EVA |
No associated diseases with Q64595
1 regional properties for Q64595
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 16 - 138 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.12 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| cGMP-dependent protein kinase activity | cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| identical protein binding | Binding to an identical protein or proteins. |
| mitogen-activated protein kinase binding | Binding to a mitogen-activated protein kinase. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular hypotonic response | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. |
| circadian regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| negative regulation of cell volume | Any process that decreases cell volume. |
| negative regulation of chloride transport | Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport. |
| negative regulation of chondrocyte proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. |
| peptidyl-serine autophosphorylation | The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of chondrocyte differentiation | Any process that modulates the frequency, rate or extent of chondrocyte differentiation. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00516 | PRKG1 | cGMP-dependent protein kinase 1 | Bos taurus (Bovine) | SS |
| Q03043 | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B | Drosophila melanogaster (Fruit fly) | SS |
| Q13976 | PRKG1 | cGMP-dependent protein kinase 1 | Homo sapiens (Human) | EV |
| Q13237 | PRKG2 | cGMP-dependent protein kinase 2 | Homo sapiens (Human) | PR |
| P0C605 | Prkg1 | cGMP-dependent protein kinase 1 | Mus musculus (Mouse) | SS |
| Q61410 | Prkg2 | cGMP-dependent protein kinase 2 | Mus musculus (Mouse) | PR |
| O76360 | egl-4 | cGMP-dependent protein kinase egl-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNGSVKPKH | SKHPDGQSGN | LSNEALRSKV | AELEREVKRK | DAELQEREYH | LKELREQLAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QTVAIAELTE | ELQSKCIQLN | KLQDVIHVQG | GSPLQASPDK | VPLDVHRKTS | GLVSLHSRRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AKAGVSAEPT | SRTYDLNKPP | EFSFEKARVR | KDSSEKKLIT | DALNKNQFLK | RLDPQQIKDM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VECMYGRNYQ | QGSYIVKQGE | PGNHIFVLAE | GRLEVFQGEK | LLSSIPMWTT | FGELAILYNC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TRTASVKAIT | NVKTWALDRE | VFQNIMRRTA | QARDEEYRNF | LRSVSLLKNL | PEDKLTKIID |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CLEVEYYDKG | DYIIREGEEG | STFFILAKGK | VKVTQSTEGH | DQPQLIKTLQ | KGEYFGEKAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISDDVRSANI | IAEENDVACL | VIDRETFNQT | VGTFDELQKY | LEGYVATLNR | DDEKRHAKRS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MSSWKLSKAL | SLEMIQLKEK | VARFSSTSPF | QNLEIIATLG | VGGFGRVELV | KVKNENIAFA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MKCIRKKHIV | DTKQQEHVYS | EKRILEELCS | PFIVKLYRTF | KDNKYVYMLL | EACLGGELWS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILRDRGSFDE | PTSKFCVACV | TEAFDYLHRL | GIIYRDLKPE | NLILDADGYL | KLVDFGFAKK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IGSGQKTWTF | CGTPEYVAPE | VILNKGHDFS | VDFWSLGILV | YELLTGNPPF | SGIDQMMTYN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LILKGIEKMD | FPRKITRRPE | DLIRRLCRQN | PTERLGNLKN | GINDIKKHRW | LNGFNWEGLK |
| 730 | 740 | 750 | 760 | ||
| ARSLPSPLRR | ELSGPIDHSY | FDKYPPEKGV | PPDEMSGWDK | DF |