Q64205
PR
Gene name |
Dlx3 |
Protein name |
Homeobox protein DLX-3 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13393 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q64205
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q64205-F1 | Predicted | AlphaFoldDB |
2 variants for Q64205
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389169229 | 192 | E>K | No | EVA | |
| rs3389164896 | 225 | A>S | No | EVA |
No associated diseases with Q64205
6 regional properties for Q64205
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Helix-turn-helix motif | 158 - 183 | IPR000047 |
| domain | Homeobox domain | 127 - 191 | IPR001356 |
| conserved_site | Homeobox, conserved site | 162 - 185 | IPR017970 |
| domain | Homeobox domain, metazoa | 151 - 162 | IPR020479-1 |
| domain | Homeobox domain, metazoa | 166 - 185 | IPR020479-2 |
| domain | Distal-less-like homeobox protein, N-terminal domain | 27 - 106 | IPR022135 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| blood vessel development | The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. |
| BMP signaling pathway | The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| epithelial cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. |
| gene expression | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. |
| hair cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a hair cell. |
| hair cycle | The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. |
| hair follicle cell proliferation | The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population. |
| hair follicle development | The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. |
| hair follicle morphogenesis | The process in which the anatomical structures of the hair follicle are generated and organized. |
| odontoblast differentiation | The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin. |
| odontogenesis of dentin-containing tooth | The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. |
| placenta development | The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P50577 | DLX5 | Homeobox protein DLX-5 | Gallus gallus (Chicken) | PR |
| P56179 | DLX6 | Homeobox protein DLX-6 | Homo sapiens (Human) | PR |
| O60479 | DLX3 | Homeobox protein DLX-3 | Homo sapiens (Human) | PR |
| Q810B3 | Bsx | Brain-specific homeobox protein homolog | Mus musculus (Mouse) | PR |
| P70396 | Dlx5 | Homeobox protein DLX-5 | Mus musculus (Mouse) | PR |
| P70397 | Dlx6 | Homeobox protein DLX-6 | Mus musculus (Mouse) | PR |
| P50575 | Dlx5 | Homeobox protein DLX-5 | Rattus norvegicus (Rat) | PR |
| Q9FN29 | ATHB-52 | Homeobox-leucine zipper protein ATHB-52 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q98875 | dlx1a | Homeobox protein Dlx1a | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q98878 | dlx4b | Homeobox protein Dlx4b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| P50574 | dlx2a | Homeobox protein Dlx2a | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q01702 | dlx3b | Homeobox protein Dlx3b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGSFDRKLS | SILTDISSSL | SCHAGSKDSP | TLPESTVTDL | GYYSAPQHDY | YSGQPYGQTV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NPYTYHHQFN | LNGLAGTGAY | SPKSEYTYGG | SYRQYGAYRE | QPLPAQDPVS | VKEEPEAEVR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MVNGKPKKVR | KPRTIYSSYQ | LAALQRRFQK | AQYLALPERA | ELAAQLGLTQ | TQVKIWFQNR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSKFKKLYKN | GEVPLEHSPN | NSDSMACNSP | PSPALWDTSS | HSTPAPARNP | LPPPLPYSAS |
| 250 | 260 | 270 | 280 | ||
| PNYLDDPTNS | WYHTQNLSGP | HLQQQPPQPA | TLHHASPGPP | PNPGAVY |