Q641K5
Gene name |
Nuak1 (Kiaa0537, Omphk1) |
Protein name |
NUAK family SNF1-like kinase 1 |
Names |
AMPK-related protein kinase 5, Omphalocele kinase 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:77976 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
196-218 (Activation loop from InterPro)
Target domain |
56-307 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q641K5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q641K5-F1 | Predicted | AlphaFoldDB |
27 variants for Q641K5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3413077678 | 31 | T>A | No | EVA | |
| rs1132631133 | 54 | H>R | No | EVA | |
| rs3401015957 | 81 | V>A | No | EVA | |
| rs3389129693 | 145 | I>F | No | EVA | |
| rs3389060400 | 205 | Q>H | No | EVA | |
| rs3389124648 | 211 | Q>R | No | EVA | |
| rs3389107611 | 251 | T>A | No | EVA | |
| rs3389121989 | 264 | R>L | No | EVA | |
| rs3389107602 | 274 | P>H | No | EVA | |
| rs3389119873 | 304 | H>N | No | EVA | |
| rs232602838 | 405 | R>W | No | EVA | |
| rs864304049 | 408 | S>G | No | EVA | |
| rs3389124623 | 430 | F>I | No | EVA | |
| rs3389119101 | 441 | I>T | No | EVA | |
| rs3389097010 | 461 | A>V | No | EVA | |
| rs3410610976 | 465 | K>* | No | EVA | |
| rs3389111410 | 485 | R>C | No | EVA | |
| rs864274261 | 488 | S>P | No | EVA | |
| rs3389128760 | 494 | S>I | No | EVA | |
| rs3389119906 | 505 | S>Y | No | EVA | |
| rs232902575 | 507 | P>S | No | EVA | |
| rs3389119889 | 513 | G>E | No | EVA | |
| rs3389107641 | 537 | T>I | No | EVA | |
| rs3401407210 | 562 | I>S | No | EVA | |
| rs3401165664 | 574 | S>T | No | EVA | |
| rs258687031 | 578 | V>I | No | EVA | |
| rs3389124630 | 606 | E>D | No | EVA |
No associated diseases with Q641K5
5 regional properties for Q641K5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 13 - 268 | IPR000719 |
| domain | NAF domain | 309 - 370 | IPR004041 |
| active_site | Serine/threonine-protein kinase, active site | 132 - 144 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 19 - 42 | IPR017441 |
| domain | NAF/FISL domain | 307 - 331 | IPR018451 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| p53 binding | Binding to one of the p53 family of proteins. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| cellular response to glucose starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
| regulation of cellular senescence | Any process that modulates the frequency, rate or extent of cellular senescence. |
| regulation of myosin-light-chain-phosphatase activity | Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06782 | SNF1 | Carbon catabolite-derepressing protein kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| O60285 | NUAK1 | NUAK family SNF1-like kinase 1 | Homo sapiens (Human) | PR |
| O35280 | Chek1 | Serine/threonine-protein kinase Chk1 | Mus musculus (Mouse) | PR |
| Q69Z98 | Brsk2 | Serine/threonine-protein kinase BRSK2 | Mus musculus (Mouse) | EV |
| Q5RJI5 | Brsk1 | Serine/threonine-protein kinase BRSK1 | Mus musculus (Mouse) | EV |
| Q61846 | Melk | Maternal embryonic leucine zipper kinase | Mus musculus (Mouse) | PR |
| O54863 | Tssk2 | Testis-specific serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q61241 | Tssk1b | Testis-specific serine/threonine-protein kinase 1 | Mus musculus (Mouse) | PR |
| Q8C0X8 | Sperm motility kinase X | Mus musculus (Mouse) | PR | |
| A0AUV4 | Gm7168 | Sperm motility kinase Y | Mus musculus (Mouse) | PR |
| Q8C0N0 | Gm4922 | Sperm motility kinase Z | Mus musculus (Mouse) | PR |
| Q5EG47 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Mus musculus (Mouse) | SS |
| Q8BRK8 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Mus musculus (Mouse) | SS |
| A2KF29 | Smoktcr | Sperm motility kinase Tcr mutant form | Mus musculus (Mouse) | PR |
| Q8LIG4 | CIPK3 | CBL-interacting protein kinase 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q5QNM6 | CIPK13 | Putative CBL-interacting protein kinase 13 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ERS4 | CIPK16 | CBL-interacting protein kinase 16 | Oryza sativa subsp japonica (Rice) | PR |
| Q5JLQ9 | CIPK30 | CBL-interacting protein kinase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q1 | OSK4 | Serine/threonine protein kinase OSK4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q852Q2 | OSK1 | Serine/threonine protein kinase OSK1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6ZLP5 | CIPK23 | CBL-interacting protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QY53 | CIPK32 | CBL-interacting protein kinase 32 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAX3 | CIPK33 | CBL-interacting protein kinase 33 | Oryza sativa subsp japonica (Rice) | PR |
| O22971 | CIPK13 | CBL-interacting serine/threonine-protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDI3 | CIPK24 | CBL-interacting serine/threonine-protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94CG0 | CIPK21 | CBL-interacting serine/threonine-protein kinase 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O65554 | CIPK6 | CBL-interacting serine/threonine-protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93VD3 | CIPK23 | CBL-interacting serine/threonine-protein kinase 23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJ54 | CIPK20 | CBL-interacting serine/threonine-protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLZ3 | KIN12 | SNF1-related protein kinase catalytic subunit alpha KIN12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q2V452 | CIPK3 | CBL-interacting serine/threonine-protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P92958 | KIN11 | SNF1-related protein kinase catalytic subunit alpha KIN11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38997 | KIN10 | SNF1-related protein kinase catalytic subunit alpha KIN10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGAAVSAAG | DGPAVETGLP | GSPLEAVAGA | TAAPVEPRKP | HGVKRHHHKH | NLKHRYELQE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLGKGTYGKV | KRATERFSGR | VVAIKSIRKD | KIKDELDMVH | IRREIEIMSS | LNHPHIISIY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVFENKDKIV | IIMEYASKGE | LYDYISERRR | LSERETRHFF | RQIVSAVHYC | HKNGVVHRDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLENILLDDN | CNIKIADFGL | SNLYQKDKFL | QTFCGSPLYA | SPEIVNGRPY | RGPEVDSWAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GVLLYTLIYG | TMPFDGFDHK | NLIRQISSGE | YREPTQPSDA | RGLIRWMLMV | NPDRRATIED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IANHWWVNWG | YKSSVCDCDA | LPDSESPLLA | RIIDWHHRST | GLQAEAEAKM | KGLAKPGASE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVLERQRSLK | KSKKENDFPQ | SGQDSVPESP | SKLSSKRPKG | ILKKRSNSEH | RSHSTGFIEG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IVSPALPSPF | KMEQDLCRTA | IPLPSSPEAD | MSGKLSLKQS | ATMPKKGILK | KTQQRESGYY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SSPERSESSE | LLDSNDVVIS | GGLSSPPPDP | ARGTSHSLSC | RRKGILKHSS | RYSDGGTDPA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LTRPEMPTLE | SLSPPGVPSD | GISRSYSRPS | SIISDDSVLS | SDSFDLLELQ | ENRPARQRIR |
| 610 | 620 | 630 | 640 | 650 | |
| SCVSAENFLQ | LQDFETPHNR | PRPQYLKRLA | DSSFSLLTDM | DDVTQVYKKA | LEICSKLN |