Q63945

SS
Gene name
Set (Ab1-115)
Protein name
Protein SET
Names
Liver regeneration-related protein LRRGR00002 , Phosphatase 2A inhibitor I2PP2A , I-2PP2A , Template-activating factor I , TAF-I
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:307947
EC number
Protein Class

Descriptions

Template-activating factor I (TAF-I) is a multifunctional protein that plays a role in apoptosis, transcription, nucleosome assembly, and histone chaperoning. In human and murine cells, two TAF-I subtypes exist, namely TAF-Iɑ and TAF-Iβ. In comparison to the histone chaperone activity of TAF-Iβ, TAF-Iɑ exhibits reduced histone chaperone activity due to the N-terminal region of TAF-Iɑ autoinhibiting its activity via intramolecular interaction with its C-terminal region. The replacement of basic amino acids within the N-terminal region with alanines disrupts the intramolecular interactions between the N- and C-terminal regions, enhancing the histone chaperone activity to a similar extent to that of TAF-Iβ.

Autoinhibitory domains (AIDs)

1-37 (N-terminal regions) SS

Target domain

237-289 (C-terminal regions)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q63945

Entry ID Method Resolution Chain Position Source
AF-Q63945-F1 Predicted AlphaFoldDB

No variants for Q63945

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63945

No associated diseases with Q63945

No regional properties for Q63945

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q63945

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Endoplasmic reticulum
  • Nucleus, nucleoplasm
  • In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum
  • The SET complex is associated with the endoplasmic reticulum
  • Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus
  • Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

3 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

3 GO annotations of biological process

Name Definition
endothelial cell differentiation The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19110 TSPY1 Testis-specific Y-encoded protein 1 Bos taurus (Bovine) PR
Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 Homo sapiens (Human) PR
Q8N831 TSPYL6 Testis-specific Y-encoded-like protein 6 Homo sapiens (Human) PR
P0DME0 SETSIP Protein SETSIP Homo sapiens (Human) SS
Q01105 SET Protein SET Homo sapiens (Human) SS
Q9EQU5 Set Protein SET Mus musculus (Mouse) EV
Q9R1M3 Tspy1 Testis-specific Y-encoded protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAPKRQSAIL PQPKKPRPVA APKLEDKSAS PGLPKGEKEQ QEAIEHIDEV QNEIDRLNEQ
70 80 90 100 110 120
ASEEILKVEQ KYNKLRQPFF QKRSELIAKI PNFWVTTFVN HPQVSALLGE EDEEALHYLT
130 140 150 160 170 180
RVEVTEFEDI KSGYRIDFYF DENPYFENKV LSKEFHLNES GDPSSKSTEI KWKSGKDLTK
190 200 210 220 230 240
RSSQTQNKAS RKRQHEEPES FFTWFTDHSD AGADELGEVI KDDIWPNPLQ YYLVPDMDDE
250 260 270 280
EGEAEDDDDD DEEEEGLEDI DEEGDEDEGE EDDDEDEGEE GEEDEGEDD