Q63744
SS
Descriptions
DLC1 encodes a Rho GTPase-activating protein (RhoGAP) and negative regulator of specific Rho family proteins (RhoA-C and Cdc42). DLC1 is a multi-domain protein, with the RhoGAP catalytic domain flanked by an amino-terminal sterile motif (SAM) and a carboxyl-terminal START domain. In a study with human DLC1 isoform 1, truncation of SAM domain activates RhoGAP catalytic domain.
Autoinhibitory domains (AIDs)
Target domain |
641-847 (Rho-GAP domain) |
Relief mechanism |
Cleavage |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q63744
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q63744-F1 | Predicted | AlphaFoldDB |
No variants for Q63744
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q63744 | |||||
No associated diseases with Q63744
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cortical actin cytoskeleton | The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| lipid binding | Binding to a lipid. |
| phospholipase binding | Binding to a phospholipase. |
| SH2 domain binding | Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
| vinculin binding | Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. |
| activation of phospholipase C activity | The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| focal adhesion assembly | The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. |
| forebrain development | The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). |
| heart morphogenesis | The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| hindbrain morphogenesis | The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of focal adhesion assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
| negative regulation of Rho protein signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. |
| negative regulation of stress fiber assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| neural tube closure | The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. |
| positive regulation of execution phase of apoptosis | Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. |
| positive regulation of protein dephosphorylation | Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of Rho protein signal transduction | Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7E300 | DLC1 | Rho GTPase-activating protein 7 | Bos taurus (Bovine) | SS |
| B9VTT2 | DLC1 | Rho GTPase-activating protein 7 | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| Q9P2N2 | ARHGAP28 | Rho GTPase-activating protein 28 | Homo sapiens (Human) | PR |
| Q8BN58 | Arhgap28 | Rho GTPase-activating protein 28 | Mus musculus (Mouse) | PR |
| Q9R0Z9 | Dlc1 | Rho GTPase-activating protein 7 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCRDEPDTMI | LTQIEAKEAC | DWLRVTGFPQ | YAQLYEDLLF | PIDIALVKRE | HDFLDRDAIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALCRRLNTLN | KCAVMKLEIS | PHRKRSEDSD | EEEPCAISGK | WTFQRDSKRW | SRLEEFDVFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKQDPIPGSP | DNSRLQSATS | RESMLTDLSE | HQEVSSIRSL | SSTSSSAPTH | VPHSGEATTP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RTNSVISVCS | SSHFVGNEDS | FSSLPSPKEL | SSFSFSMKGH | EKNTKSKTRS | LLKRMESLKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KGSHHSKHKA | PSKLGLIISA | PILQEGMDEE | KLKQLNCVEI | SALNGNHINV | PMVRKRSVSN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| STQTSSSSSQ | SETSSAVSTP | SPVTRTRSLS | TCNKRVGMYL | EGFDPFSQSA | FNNVTEQNYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NRESYPEDTV | FYIPEDHKPG | TFPKALSNGS | FCPSGNSSVN | WRTGSFHGPG | HLSLRRENSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DSPKELKRRN | SSSSVSSRMS | IYDNVPGSIL | YSSSGELADL | ENEDIFPELD | DILYHVKGMQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RIVNQWSEKF | SDEGDSDSAL | DSVSPCPSSP | KQIHLDVDHD | RRTPSDLDST | GNSLNEPEEP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TDIPERRDSG | VGASLTRCNR | HRLRWHSFQS | SHRPSLNSVS | LQINCQSVAQ | MNLLQKYSLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KLTALLEKYT | PSNKHGFSWA | VPKFMKRIKV | PDYKDRSVFG | VPLTVNVQRS | GQPLPQSIQQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AMRYLRNHCL | DQVGLFRKSG | VKSRIQALRQ | MNESAEDYVN | YEGQSAYDVA | DMLKQYFRDL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PEPLMTNKLS | ETFLQIYQYV | PKDQRLQAIK | AAIMLLPDEN | REVLQTLLYF | LSHVTAAVKE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NQMTPTNLAV | CLAPSLFHLN | TLKRENSSPR | VMQRKQSLGK | PDQKDLNENL | AATQGLAHMI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AECKKLFQVP | EEMSRCRNSY | TEQELKPLTL | EALGHLSNDQ | PADYRHFLQD | CVDGLFKEVK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EKFKGWVSYP | TSEQAELSYK | KVSEGPPLRL | WRATIEVPAA | PEEILKRLLK | EQHLWDVDLL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DSKVIEILDS | QTEIYQYVQN | SMAPHPARDY | VVLRTWRTNL | PRGACALLFT | SVDHDRAPVA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GVRVNVLLSR | YLIEPCGSGK | SKLTYMCRAD | LRGHMPEWYT | KSFGHLCAAE | VVKIRDSFSN |
| 1090 | |||||
| QSTESKDTRS | R |