Q63504
PR
Gene name |
Nr1d2 |
Protein name |
Nuclear receptor subfamily 1 group D member 2 |
Names |
EAR4, Rev-erb-beta |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:259241 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q63504
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q63504-F1 | Predicted | AlphaFoldDB |
1 variants for Q63504
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8154910 | 421 | R>C | No | EVA |
No associated diseases with Q63504
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
| zinc ion binding | Binding to a zinc ion (Zn). |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| circadian behavior | The specific behavior of an organism that recurs with a regularity of approximately 24 hours. |
| energy homeostasis | Any process involved in the balance between food intake (energy input) and energy expenditure. |
| hormone-mediated signaling pathway | The series of molecular signals mediated by the detection of a hormone. |
| lipid homeostasis | Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of circadian rhythm | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| regulation of lipid metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. |
| regulation of skeletal muscle cell differentiation | Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELNAGGVIA | YISSSSSASS | PASCHSEGSE | NSFQSSSSSV | PSSPNSSNCD | ANGNPKNTDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSIDGVLKSD | RTDCPVKTGK | PGAPGMTKSH | SGMTKFSGMV | LLCKVCGDVA | SGFHYGVHAC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGCKGFFRRS | IQQNIQYKKC | LKNENCSIMR | MNRNRCQQCR | FKKCLSVGMS | RDAVRFGRIP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KREKQRMLIE | MQSAMKTMMS | TQFGGHLQSD | TLAEPHEQSV | PPAQEQLRPK | PQLEQENIKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPPPSDFAKE | EVIGMVTRAH | KDTFLYNQEH | RENSSESMPP | HRGERIPRNV | EQYNLNHDHR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GGGLHSHFPC | SESQQHLSGQ | YKGRNMMHYP | NGHTVCISNG | HCVNFSSAYP | QRVCDRIPVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GCSQTESRNS | YLCSTGGRMH | LVCPMSKSPY | VDPQKSGHEI | WEEFSMSFTP | AVKEVVEFAK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RIPGFRDLSQ | HDQVNLLKAG | TFEVLMVRFA | SLFDAKERTV | TFLSGKKYSV | DDLHSMGAGD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLSSMFEFSE | KLNGLQLSDE | EMSLFTAVVL | VSADRSGIEN | VNSVEALQET | LIRALRTLIM |
| 550 | 560 | 570 | |||
| KNHPNEASIF | TKLLLKLPDL | RSLNNMHSEE | LLAFKVHP |