Q63493
PR
Gene name |
Cd1d (Cd1d1) |
Protein name |
Antigen-presenting glycoprotein CD1d |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25109 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q63493
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q63493-F1 | Predicted | AlphaFoldDB |
No variants for Q63493
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q63493 | |||||
No associated diseases with Q63493
Functions
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| cell adhesion molecule binding | Binding to a cell adhesion molecule. |
| endogenous lipid antigen binding | Binding to an endogenous cellular lipid antigen. |
| exogenous lipid antigen binding | Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids). |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| lipid antigen binding | Binding to a lipid antigen. |
| lipopeptide binding | Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids. |
| T cell receptor binding | Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| antigen processing and presentation | The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. |
| antigen processing and presentation, endogenous lipid antigen via MHC class Ib | The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. |
| antigen processing and presentation, exogenous lipid antigen via MHC class Ib | The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| NK T cell differentiation | The process in which a precursor cell type acquires the specialized features of a NK T cell. |
| positive regulation of interferon-gamma production | Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. |
| positive regulation of interleukin-2 production | Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. |
| positive regulation of interleukin-4 production | Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. |
| positive regulation of macrophage activation | Any process that stimulates, induces or increases the rate of macrophage activation. |
| positive regulation of NK T cell activation | Any process that activates or increases the frequency, rate or extent of natural killer T cell activation. |
| positive regulation of NK T cell differentiation | Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation. |
| positive regulation of T cell mediated cytotoxicity | Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. |
| positive regulation of T cell proliferation | Any process that activates or increases the rate or extent of T cell proliferation. |
| positive thymic T cell selection | The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. |
| regulation of immature T cell proliferation in thymus | Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus. |
| regulation of immune response | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q4ACW4 | CD1D | Antigen-presenting glycoprotein CD1d | Pan troglodytes (Chimpanzee) | PR |
| P29017 | CD1C | T-cell surface glycoprotein CD1c | Homo sapiens (Human) | PR |
| P15813 | CD1D | Antigen-presenting glycoprotein CD1d | Homo sapiens (Human) | PR |
| O35799 | Hfe | Hereditary hemochromatosis protein homolog | Rattus norvegicus (Rat) | PR |
| P13599 | Fcgrt | IgG receptor FcRn large subunit p51 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLYLPCLLLW | AFPQFWGQSE | VQQNYTFGCL | QISSFANRSW | SRTDSVVWLG | DLQTHRWSND |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDTISFTKPW | SQGKFSNQQW | EKLQHMFQVY | RTSFTRDIKE | IVKMMSPKED | YPIEVQLSAG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CEMYPGNASE | SFLHVAFQGE | YVVRFHGTSW | QKVPEAPSWL | DLPIKMLNAD | EGTRETVQIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNDTCPQFVR | GLLEAGKPDL | EKQEKPVAWL | SRGPNPAHGH | LQLVCHVSGF | HPKPVWVMWM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RGDQEQGGTH | RGDILPNADE | TWYLQATLDV | EAGDEAGLAC | RVKHSSLEGQ | DIILYWGGRQ |
| 310 | 320 | 330 | |||
| VSPVLIFLIV | GVLVLVVCAV | AYYIIRKRRR | SYQDIM |