Q63449

SS
Gene name
Pgr (Nr3c3)
Protein name
Progesterone receptor
Names
PR , Nuclear receptor subfamily 3 group C member 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25154
EC number
Protein Class

Descriptions

Human progesterone receptor A (PR-A) and B (PR-B) isoforms are members of the nuclear receptor family of ligand-activated transcription factors. The two PR proteins are identical except that PR-B contains an additional 164 N-terminal amino acids in the B upstream segment (BUS). <br>In PR-B, the deletion of the autoinhibitory region increases the transcriptional activity. In PR-A, deletion of the same region also increases its transcriptional activity. The autoinhibitory region contains a SUMO-1 binding motif (IKEE) and mutation within the motif leads to loss of autoinhibitory function.

Autoinhibitory domains (AIDs)

374-396 (Autoinhibitory region) SS

Target domain

677-923 (hormone binding domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q63449

Entry ID Method Resolution Chain Position Source
AF-Q63449-F1 Predicted AlphaFoldDB

No variants for Q63449

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63449

No associated diseases with Q63449

2 regional properties for Q63449

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 669 - 903 IPR000536
domain Zinc finger, nuclear hormone receptor-type 554 - 629 IPR001628

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Nucleoplasmic shuttling is both hormone- and cell cycle-dependent
  • On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

14 GO annotations of molecular function

Name Definition
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
estrogen response element binding Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.
hormone binding Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.
identical protein binding Binding to an identical protein or proteins.
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
nuclear steroid receptor activity Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
nucleic acid binding Binding to a nucleic acid.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
transcription coactivator binding Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
zinc ion binding Binding to a zinc ion (Zn).

32 GO annotations of biological process

Name Definition
cellular response to estrogen stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
cellular response to follicle-stimulating hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
cellular response to gonadotropin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
cellular response to luteinizing hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.
cellular response to wortmannin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus.
diterpenoid metabolic process The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.
epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
estrous cycle A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
female mating behavior The specific behavior of a female organism that is associated with reproduction.
glandular epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
intracellular steroid hormone receptor signaling pathway The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor.
lung alveolus development The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
luteinization The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.
mammary gland development The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of granulosa cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process.
ovulation from ovarian follicle The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.
paracrine signaling The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of smooth muscle cell migration Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
progesterone receptor signaling pathway The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to cocaine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
response to progesterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
tertiary branching involved in mammary gland duct morphogenesis The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy.

29 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9TTR7 NR2F2 COUP transcription factor 2 Bos taurus (Bovine) PR
O18971 PPARG Peroxisome proliferator-activated receptor gamma Bos taurus (Bovine) PR
Q90733 NR2F2 COUP transcription factor 2 Gallus gallus (Chicken) PR
P68306 THRB Thyroid hormone receptor beta Gallus gallus (Chicken) PR
A7X8B3 PGR Progesterone receptor Pan troglodytes (Chimpanzee) SS
Q9GLW0 PGR Progesterone receptor Canis lupus familiaris (Dog) (Canis familiaris) SS
P37231 PPARG Peroxisome proliferator-activated receptor gamma Homo sapiens (Human) PR
P10588 NR2F6 Nuclear receptor subfamily 2 group F member 6 Homo sapiens (Human) PR
P10589 NR2F1 COUP transcription factor 1 Homo sapiens (Human) PR
O75469 NR1I2 Nuclear receptor subfamily 1 group I member 2 Homo sapiens (Human) PR
P24468 NR2F2 COUP transcription factor 2 Homo sapiens (Human) PR
P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 Homo sapiens (Human) PR
P06401 PGR Progesterone receptor Homo sapiens (Human) EV
P35396 Ppard Peroxisome proliferator-activated receptor delta Mus musculus (Mouse) PR
P43136 Nr2f6 Nuclear receptor subfamily 2 group F member 6 Mus musculus (Mouse) PR
P43135 Nr2f2 COUP transcription factor 2 Mus musculus (Mouse) PR
Q9Z0Y9 Nr1h3 Oxysterols receptor LXR-alpha Mus musculus (Mouse) PR
Q00175 Pgr Progesterone receptor Mus musculus (Mouse) SS
O62807 PPARG Peroxisome proliferator-activated receptor gamma Sus scrofa (Pig) PR
O09018 Nr2f2 COUP transcription factor 2 Rattus norvegicus (Rat) PR
Q8SQ01 NR1I2 Nuclear receptor subfamily 1 group I member 2 Macaca mulatta (Rhesus macaque) PR
G5EFF5 daf-12 Nuclear hormone receptor family member daf-12 Caenorhabditis elegans PR
O45460 nhr-54 Nuclear hormone receptor family member nhr-54 Caenorhabditis elegans PR
Q20765 nhr-7 Nuclear hormone receptor family member nhr-7 Caenorhabditis elegans PR
Q21006 nhr-34 Nuclear hormone receptor family member nhr-34 Caenorhabditis elegans PR
O17928 nhr-52 Nuclear hormone receptor family member nhr-52 Caenorhabditis elegans PR
Q21878 nhr-1 Nuclear hormone receptor family member nhr-1 Caenorhabditis elegans PR
O18141 nhr-79 Nuclear hormone receptor family member nhr-79 Caenorhabditis elegans PR
Q6PH18 nr2f1b Nuclear receptor subfamily 2 group F member 1-B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTELQAKDPR TLHTSGAAPS PTHVGSPLLA RLDPDPFQGS QHSDASSVVS PIPISLDRLL
70 80 90 100 110 120
FSRSCQAQEL PDEKTQNQQS LSDVEGAFSG VEASRRRSRN PRAPEKDSRL LDSVLDTLLA
130 140 150 160 170 180
PSGPEQSQTS PPACEAITSW CLFGPELPED PRSVPATKGL LSPLMSRPES KAGDSSGTGA
190 200 210 220 230 240
GQKVLPKAVS PPRQLLLPTS GSAHWPGAGV KPSQQPATVE VEEDGGLETE GSAGPLLKSK
250 260 270 280 290 300
PRALEGMCSG GGVTANAPGA APGGVTLVPK EDSRFSAPRV SLEQDAPVAP GRSPLATTVV
310 320 330 340 350 360
DFIHVPILPL NHALLAARTR QLLEGDSYDG GAAAQVPFAP PRGSPSAPSP PVPCGDFPDC
370 380 390 400 410 420
TYPPEGDPKE DGFPVYGEFQ PPGLKIKEEE EGTEAASRSP RPYLLAGASA ATFPDFPLPP
430 440 450 460 470 480
RPPRAPPSRP GEAAVAAPSA AVSPVSSSGS ALECILYKAE GAPPTQGSFA PLPCKPPAAS
490 500 510 520 530 540
SCLLPRDSLP AAPTSSAAPA IYPPLGLNGL PQLGYQAAVL KDSLPQVYPP YLNYLRPDSE
550 560 570 580 590 600
ASQSPQYGFD SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN YLCAGRNDCI
610 620 630 640 650 660
VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVMRA LDGVALPQSV AFPNESQTLG
670 680 690 700 710 720
QRITFSPNQE IQLVPPLINL LMSIEPDVVY AGHDNTKPDT SSSLLTSLNQ LGERQLLSVV
730 740 750 760 770 780
KWSKSLPGFR NLHIDDQITL IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP DLILNEQRMK
790 800 810 820 830 840
ELSFYSLCLT MWQIPQEFVK LQVTHEEFLC MKVLLLLNTI PLEGLRSQSQ FEEMRSSYIR
850 860 870 880 890 900
ELIKAIGLRQ KGVVPSSQRF YQLTKLLDSL HDLVKQLHLY CLNTFIQSRA LAVEFPEMMS
910 920
EVIAAQLPKI LAGMVKPLLF HKK