Q62956
SS
Gene name |
Erbb4 (Tyro-2) |
Protein name |
Receptor tyrosine-protein kinase erbB-4 |
Names |
EC 2.7.10.1 , Proto-oncogene-like protein c-ErbB-4 [Cleaved into: ERBB4 intracellular domain , 4ICD , E4ICD , s80HER4] |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:59323 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Epidermal growth factor receptor plays critical roles in regulating cell proliferation, differentiation, and migration. The extracellular region of the EGF receptor contains four subdomains (domains I, II, III, and IV). Self-association of EGFR is autoinhibited by intramolecular interaction between domain II and IV, which sequesters the dimerization arm within domain II. Glycosylation of an Asn residue in domain IV induces autoinhibition while its mutation disrupts autoinhibition. Glycosylations of Asn residues within domain II reduce autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
165-306 (Domain II) |
Relief mechanism |
Partner binding, PTM |
Assay |
|
Accessory elements
860-885 (Activation loop from InterPro)
Target domain |
718-985 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Zhang X et al. (2006) "An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor", Cell, 125, 1137-49
- Ferguson KM et al. (2003) "EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization", Molecular cell, 11, 507-17
- Whitson KB et al. (2005) "Functional effects of glycosylation at Asn-579 of the epidermal growth factor receptor", Biochemistry, 44, 14920-31
- Contessa JN et al. (2008) "Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells", Cancer research, 68, 3803-9
- Huang X et al. (2009) "Structural insights into the inhibited states of the Mer receptor tyrosine kinase", Journal of structural biology, 165, 88-96
- Kovacs E et al. (2015) "Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor", Molecular and cellular biology, 35, 3083-102
Autoinhibited structure
Activated structure
1 structures for Q62956
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62956-F1 | Predicted | AlphaFoldDB |
No variants for Q62956
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62956 | |||||
No associated diseases with Q62956
15 regional properties for Q62956
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor L-domain | 55 - 166 | IPR000494-1 |
| domain | Receptor L-domain | 358 - 477 | IPR000494-2 |
| domain | Protein kinase domain | 718 - 985 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 719 - 973 | IPR001245 |
| domain | Furin-like cysteine-rich domain | 186 - 335 | IPR006211 |
| repeat | Furin-like repeat | 183 - 223 | IPR006212-1 |
| repeat | Furin-like repeat | 226 - 274 | IPR006212-2 |
| repeat | Furin-like repeat | 493 - 553 | IPR006212-3 |
| repeat | Furin-like repeat | 549 - 599 | IPR006212-4 |
| repeat | Furin-like repeat | 611 - 659 | IPR006212-5 |
| active_site | Tyrosine-protein kinase, active site | 839 - 851 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 724 - 751 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 718 - 974 | IPR020635 |
| domain | Growth factor receptor domain 4 | 502 - 633 | IPR032778 |
| domain | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment | 653 - 688 | IPR049328 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
15 GO annotations of cellular component
| Name | Definition |
|---|---|
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| epidermal growth factor receptor activity | Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| epidermal growth factor receptor binding | Binding to an epidermal growth factor receptor. |
| GABA receptor binding | Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. |
| neuregulin receptor activity | Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
51 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac muscle tissue regeneration | The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. |
| cell fate commitment | The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| cellular response to epidermal growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. |
| central nervous system morphogenesis | The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| embryonic pattern specification | The process that results in the patterns of cell differentiation that will arise in an embryo. |
| ERBB2-ERBB4 signaling pathway | The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. |
| ERBB4 signaling pathway | The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| ERBB4-ERBB4 signaling pathway | The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| establishment of planar polarity involved in nephron morphogenesis | Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| lactation | The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. |
| mammary gland alveolus development | The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. |
| mammary gland development | The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. |
| mammary gland epithelial cell differentiation | The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. |
| mitochondrial fragmentation involved in apoptotic process | The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of muscle cell apoptotic process | Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neural crest cell migration | The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. |
| neurogenesis | Generation of cells within the nervous system. |
| neurotransmitter receptor localization to postsynaptic specialization membrane | A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). |
| olfactory bulb interneuron differentiation | The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| positive regulation of cardiac muscle cell proliferation | Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of epithelial cell proliferation | Any process that activates or increases the rate or extent of epithelial cell proliferation. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of glucose import | Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of phospholipid biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. |
| positive regulation of protein localization to cell surface | Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. |
| positive regulation of receptor signaling pathway via JAK-STAT | Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. |
| positive regulation of synaptic transmission, GABAergic | Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
| positive regulation of tyrosine phosphorylation of STAT protein | Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| receptor signaling pathway via JAK-STAT | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| response to progesterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| surfactant homeostasis | Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid. |
| synapse assembly | The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). |
| synapse maturation | The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development. |
| telencephalon development | The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P13387 | EGFR | Epidermal growth factor receptor | Gallus gallus (Chicken) | SS |
| P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens (Human) | SS |
| P04626 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (Human) | SS |
| P00533 | EGFR | Epidermal growth factor receptor | Homo sapiens (Human) | EV |
| Q15303 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens (Human) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| Q62799 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Rattus norvegicus (Rat) | SS |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| P06494 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Rattus norvegicus (Rat) | SS |
| Q63474 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Rattus norvegicus (Rat) | SS |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| Q00495 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Rattus norvegicus (Rat) | PR |
| P55245 | EGFR | Epidermal growth factor receptor | Macaca mulatta (Rhesus macaque) | SS |
| O16262 | nipi-4 | Protein nipi-4 | Caenorhabditis elegans | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLATGLWVW | GSLLVAARTV | QPSASQSVCA | GTENKLSSLS | DLEQQYRALR | KYYENCEVVM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GNLEITSIEH | NRDLSFLRSI | REVTGYVLVA | LNQFRYLPLE | NLRIIRGTKL | YEDRYALAIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNYRKDGNFG | LQELGLKNLT | EILNGGVYVD | QNKFLCYADT | IHWQDIVRNP | WPSNMTLVST |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IGSSGCGRCH | KSCTGRCWGP | TENHCQTLTR | TVCAEQCDGR | CYGPYVSDCC | HRECAGGCSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKDTDCFACM | NFNDSGACVT | QCPQTFVYNP | TTFQLEHNFN | AKYTYGAFCV | KKCPHNFVVD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSSCVRACPS | SKMEVEENGI | KMCKPCTDIC | PKACDGIGTG | SLMSAQTVDS | SNIDKFINCT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KINGNLIFLV | TGIHGDPYNA | IDAIDPEKLN | VFRTVREITG | FLNIQTWPPN | MTDFSVFSNL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTIGGRVLYS | GLSLLILKQQ | GITSLQFQSL | KEISAGNIYI | TDNSNLCYYH | TINWTTLFST |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNQRIVIRDN | RRAENCTAEG | MVCNHLCSND | GCWGPGPDQC | LSCRRFSRGK | ICIESCNLYD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GEFREFENGS | ICVECDSQCE | KMEDGLLTCH | GPGPDNCTKC | SHFKDGPNCV | EKCPDVLQGA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NSFIFKYADQ | DRECHPCHPN | CTQGCNGPTS | HDCIYYPWTG | HSTLPQHART | PLIAAGVIGG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LFILVIMALT | FAVYVRRKSI | KKKRALRRFL | ETELVEPLTP | SGTAPNQAQL | RILKETELKR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VKVLGSGAFG | TVYKGIWVPE | GETVKIPVAI | KILNETTGPK | ANVEFMDEAL | IMASVDHPHL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VRLLGVCLSP | TIQLVTQLMP | HGCLLEYVHE | HKDNIGSQLL | LNWCVQIAKG | MMYLEERRLV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HRDLAARNVL | VKSPNHVKIT | DFGLARLLEG | DEKEYNADGG | KMPIKWMALE | CIHYRKFTHQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SDVWSYGVTI | WELMTFGGKP | YDGIPTREIP | DLLEKGERLP | QPPICTIDVY | IVMVKCWMID |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ADSRPKFKEL | AAEFSRMARD | PQRYLVIQGD | DRMKLPSPND | SKFFQNLLDE | EDLEDMMDAE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EYLVPQAFNI | PPPIYTSRTR | IDSNRSEIGH | SPPPAYTPMS | GSQFVYQDGG | FATQQGMPMP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| YTATTSTIPE | APVAQGATAE | MFDDSCCNGT | LRKPVVPHVQ | EDSSTQRYSA | DPTVFAPERN |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PRAELDEEGY | MTPMHDKPKQ | EYLNPVEENP | FVSRRKNGDL | QALDNPEYHS | ASSGPPKAED |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| EYVNEPLYLN | TFTNALGNAE | YMKNSLLSVP | EKAKKAFDNP | DYWNHSLPPR | STLQHPDYLQ |
| 1270 | 1280 | 1290 | 1300 | ||
| EYSTKYFYKQ | NGRIRPIVAE | NPEYLSEFSL | KPGTMLPPPP | YRHRNTVV |