Q62812
SS
Descriptions
Myosin-7 (MYH7, also named Myosin heavy chain, cardiac muscle β isoform) is an actin-based motor molecule with ATPase activity essential for muscle contraction. Several mutations in MYH7 are frequent causes of hypertrophic cardiomyopathy (HCM), a disease characterized by hypercontractility and eventual hypertrophy of the left ventricle. Many HCM-causing mutations appear to reduce myosin's ability to form an autoinhibited state. In an autoinhibited state, the myosin heads fold back onto their own subfragment 2 (S2) tail in a conformation known as the interacting heads motif (IHM). One of the two heads in the dimer has its actin-binding interface buried in the folded structure; this head is referred to as the blocked head, while the other is called the free head, since its actin-binding interface is not hidden structurally. Many myosin types have the folded back IHM structure. The IHM structure correlates to an ultra-low basal ATPase rate in the absence of an action called the 'super relaxed state'. Heads lacking the S2 tail mostly have a faster basal ATPase rate referred to as the 'disordered relaxed state'. Especially, mutations in the myosin lever arm or the pliant region of the lever arm can affect myosin function either by altering its intrinsic motor activity, and/or reducing its ability to form the autoinhibited state.
Autoinhibitory domains (AIDs)
Target domain |
75-777 (Myosin head, motor domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62812
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62812-F1 | Predicted | AlphaFoldDB |
No variants for Q62812
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62812 | |||||
No associated diseases with Q62812
Functions
31 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| actin filament | A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
| actomyosin | Any complex of actin, myosin, and accessory proteins. |
| actomyosin contractile ring | A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis. |
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| brush border | The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cleavage furrow | The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. |
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| cortical cytoskeleton | The portion of the cytoskeleton that lies just beneath the plasma membrane. |
| cortical granule | A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic side of plasma membrane | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| immunological synapse | An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| myosin complex | A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
| myosin filament | A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. |
| myosin II complex | A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. |
| myosin II filament | A bipolar filament composed of myosin II molecules. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
| uropod | A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. |
16 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ADP binding | Binding to ADP, adenosine 5'-diphosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| follicle-stimulating hormone receptor binding | Binding to a follicle-stimulating hormone receptor. |
| G-protein alpha-subunit binding | Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. |
| identical protein binding | Binding to an identical protein or proteins. |
| integrin binding | Binding to an integrin. |
| microfilament motor activity | A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. |
| P-type sodium:potassium-exchanging transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein-membrane adaptor activity | The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. |
| scaffold protein binding | Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. |
45 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actin filament bundle assembly | The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. |
| actin filament bundle distribution | Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell. |
| actin filament-based movement | Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. |
| actomyosin structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. |
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| blood vessel endothelial cell migration | The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| cell motility | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. |
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| cellular response to mechanical stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. |
| cellular response to platelet-derived growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. |
| cortical granule exocytosis | The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy. |
| cytokinetic process | A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). |
| endodermal cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. |
| establishment of meiotic spindle localization | The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs. |
| establishment of T cell polarity | The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. |
| follicle-stimulating hormone signaling pathway | A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| lysosome localization | Any process in which a lysosome is transported to, and/or maintained in, a specific location. |
| meiotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. |
| membrane protein ectodomain proteolysis | The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). |
| monocyte differentiation | The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. |
| myoblast fusion | A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
| negative regulation of actin filament severing | Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing. |
| negative regulation of vascular associated smooth muscle cell migration | Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. |
| phagocytosis, engulfment | The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| plasma membrane repair | The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. |
| platelet formation | The process in which platelets bud from long processes extended by megakaryocytes. |
| positive regulation of endocytosis | Any process that activates or increases the frequency, rate or extent of endocytosis. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of focal adhesion assembly | Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
| positive regulation of G protein-coupled receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity. |
| positive regulation of inositol trisphosphate biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus | Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. |
| positive regulation of phagocytosis | Any process that activates or increases the frequency, rate or extent of phagocytosis. |
| positive regulation of protein processing in phagocytic vesicle | Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulated exocytosis | A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. |
| regulation of actin filament organization | Any process that modulates the frequency, rate or extent of actin filament organization. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of plasma membrane repair | Any process that modulates the frequency, rate or extent of plasma membrane repair. |
| uropod organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated. |
46 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BE40 | MYH1 | Myosin-1 | Bos taurus (Bovine) | SS |
| Q9BE41 | MYH2 | Myosin-2 | Bos taurus (Bovine) | SS |
| Q27991 | MYH10 | Myosin-10 | Bos taurus (Bovine) | SS |
| Q9BE39 | MYH7 | Myosin-7 | Bos taurus (Bovine) | SS |
| P10587 | MYH11 | Myosin-11 | Gallus gallus (Chicken) | SS |
| P02565 | MYH1B | Myosin-1B | Gallus gallus (Chicken) | SS |
| P13538 | Myosin heavy chain, skeletal muscle, adult | Gallus gallus (Chicken) | SS | |
| P14105 | MYH9 | Myosin-9 | Gallus gallus (Chicken) | SS |
| P05661 | Mhc | Myosin heavy chain, muscle | Drosophila melanogaster (Fruit fly) | SS |
| Q99323 | zip | Myosin heavy chain, non-muscle | Drosophila melanogaster (Fruit fly) | SS |
| P12882 | MYH1 | Myosin-1 | Homo sapiens (Human) | SS |
| Q9UKX2 | MYH2 | Myosin-2 | Homo sapiens (Human) | SS |
| Q9Y623 | MYH4 | Myosin-4 | Homo sapiens (Human) | SS |
| A7E2Y1 | MYH7B | Myosin-7B | Homo sapiens (Human) | SS |
| Q9Y2K3 | MYH15 | Myosin-15 | Homo sapiens (Human) | SS |
| P12883 | MYH7 | Myosin-7 | Homo sapiens (Human) | EV |
| P35580 | MYH10 | Myosin-10 | Homo sapiens (Human) | SS |
| P35749 | MYH11 | Myosin-11 | Homo sapiens (Human) | SS |
| P13535 | MYH8 | Myosin-8 | Homo sapiens (Human) | SS |
| P13533 | MYH6 | Myosin-6 | Homo sapiens (Human) | SS |
| Q9UKX3 | MYH13 | Myosin-13 | Homo sapiens (Human) | SS |
| P11055 | MYH3 | Myosin-3 | Homo sapiens (Human) | SS |
| Q7Z406 | MYH14 | Myosin-14 | Homo sapiens (Human) | SS |
| P35579 | MYH9 | Myosin-9 | Homo sapiens (Human) | SS |
| Q5SX39 | Myh4 | Myosin-4 | Mus musculus (Mouse) | SS |
| P13542 | Myh8 | Myosin-8 | Mus musculus (Mouse) | SS |
| Q02566 | Myh6 | Myosin-6 | Mus musculus (Mouse) | SS |
| O08638 | Myh11 | Myosin-11 | Mus musculus (Mouse) | SS |
| A2AQP0 | Myh7b | Myosin-7B | Mus musculus (Mouse) | SS |
| Q61879 | Myh10 | Myosin-10 | Mus musculus (Mouse) | SS |
| Q91Z83 | Myh7 | Myosin-7 | Mus musculus (Mouse) | SS |
| Q6URW6 | Myh14 | Myosin-14 | Mus musculus (Mouse) | SS |
| P13541 | Myh3 | Myosin-3 | Mus musculus (Mouse) | SS |
| Q5SX40 | Myh1 | Myosin-1 | Mus musculus (Mouse) | SS |
| Q8VDD5 | Myh9 | Myosin-9 | Mus musculus (Mouse) | SS |
| P79293 | MYH7 | Myosin-7 | Sus scrofa (Pig) | SS |
| Q9TV63 | MYH2 | Myosin-2 | Sus scrofa (Pig) | SS |
| P02563 | Myh6 | Myosin-6 | Rattus norvegicus (Rat) | SS |
| P02564 | Myh7 | Myosin-7 | Rattus norvegicus (Rat) | SS |
| P12847 | Myh3 | Myosin-3 | Rattus norvegicus (Rat) | SS |
| Q29RW1 | Myh4 | Myosin-4 | Rattus norvegicus (Rat) | SS |
| Q9JLT0 | Myh10 | Myosin-10 | Rattus norvegicus (Rat) | SS |
| P02566 | unc-54 | Myosin-4 | Caenorhabditis elegans | SS |
| P12844 | myo-3 | Myosin-3 | Caenorhabditis elegans | SS |
| P02567 | myo-1 | Myosin-1 | Caenorhabditis elegans | SS |
| P12845 | myo-2 | Myosin-2 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQQAADKYL | YVDKNFINNP | LAQADCGAKK | LVWVPSTKNG | FEPASLKEEV | GEEAIVELVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGKKVKVNKD | DIQKMNPPKF | SKVEDMAELT | CLNEASVLHN | LKERYYSGLI | YTYSGLFCVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INPYKNLPIY | SEEIVDMYKG | KKRHEMPPHI | YAITDTAYRS | MMQDREDQSI | LCTGESGAGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TENTKKVIQY | LAHVASSHKS | KKDQGELERQ | LLQANPILEA | FGNAKTVKND | NSSRFGKFIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| INFDVNGYIV | GANIETYLLE | KSRAIRQAKE | ERTFHIFYYL | LSGAGEHLKT | DLLLEPYNKY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RFLSNGHVTI | PGQQDKDMFQ | ETMEAMRIMG | IPEDEQMGLL | RVISGVLQLG | NIVFKKERNT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DQASMPDNTA | AQKVSHLLGI | NVTDFTRGIL | TPRIKVGRDY | VQKAQTKEQA | DFAIEALAKA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TYERMFRWLV | LRINKALDKT | KRQGASFIGI | LDIAGFEIFD | LNSFEQLCIN | YTNEKLQQLF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NHTMFILEQE | EYQREGIEWN | FIDFGLDLQP | CIDLIEKPAG | PPGILALLDE | ECWFPKATDK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SFVEKVVQEQ | GTHPKFQKPK | QLKDKADFCI | IHYAGKVDYK | ADEWLMKNMD | PLNDNIATLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HQSSDKFVSE | LWKDVDRIIG | LDQVAGMSET | ALPGAFKTRK | GMFRTVGQLY | KEQLAKLMAT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LRNTNPNFVC | CIIPNHEKKA | GKLDPHLVLD | QLRCNGVLEG | IRICRQGFPN | RVVFQEFRQR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YEILTPNSIP | KGFMDGKQAC | VLMIKALELD | SNLYRIGQSK | VFFRSGVLAH | LEEERDLKIT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DVIIGFQACC | RGYLARKAFA | KRQQQLTAMK | VLQRNCAAYL | RLRNWQWWRL | FTKVKPLLNS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IRHEDELLAK | EAELTKVREK | HLAAENRLTE | METMQSQLMA | EKLQLQEQLQ | AKTELCAEAE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ELRARLTAKK | QELEEICHDL | EARVEEEEER | CQYLQAEKKK | MQQNIQELEE | QLEEEESARQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KLQLEKVTTE | AKLKKLEEDQ | IIMEDQNCKL | AKEKKLLEDR | VAEFTTDLME | EEEKSKSLAK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LKNKHEAMIT | DLEERLRREE | KQRQELEKTR | RKLEGDSTDL | SDQIAELQAQ | IAELKMQLAK |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KEEELQAALA | RVEEEAAQKN | MALKKIRELE | TQISELQEDL | ESERACRNKA | EKQKRDLGEE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LEALKTELED | TLDSTAAQQE | LRSKREQEVS | ILKKTLEDEA | KTHEAQIQEM | RQKHSQAVEE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LAEQLEQTKR | VKATLEKAKQ | TLENERGELA | NEVKALLQGK | GDSEHKRKKV | EAQLQELQVK |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| FSEGERVRTE | LADKVSKLQV | ELDSVTGLLN | QSDSKSSKLT | KDFSALESQL | QDTQELLQEE |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| NRQKLSLSTK | LKQMEDEKNS | FREQLEEEEE | EAKRNLEKQI | ATLHAQVTDM | KKKMEDGVGC |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LETAEEAKRR | LQKDLEGLSQ | RLEEKVAAYD | KLEKTKTRLQ | QELDDLLVDL | DHQRQSVSNL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| EKKQKKFDQL | LAEEKTISAK | YAEERDRAEA | EAREKETKAL | SLARALEEAM | EQKAELERLN |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KQFRTEMEDL | MSSKDDVGKS | VHELEKSNRA | LEQQVEEMKT | QLEELEDELQ | ATEDAKLRLE |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| VNLQAMKAQF | ERDLQGRDEQ | SEEKKKQLVR | QVREMEAELE | DERKQRSIAM | AARKKLEMDL |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| KDLEAHIDTA | NKNREEAIKQ | LRKLQAQMKD | CMRDVDDTRA | SREEILAQAK | ENEKKLKSME |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| AEMIQLQEEL | AAAERAKRQA | QQERDELADE | IANSSGKGAL | ALEEKRRLEA | LIALLEEELE |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| EEQGNTELIN | DRLKKANLQI | DQINTDLNLE | RSHAQKNENA | RQQLERQNKE | LKAKLQEMES |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| AVKSKYKASI | AALEAKIAQL | EEQLDNETKE | RQAASKQVRR | AEKKLKDVLL | QVEDERRNAE |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| QFKDQADKAS | TRLKQLKRQL | EEAEEEAQRA | NASRRKLQRE | LEDATETADA | MNREVSSLKN |
| 1930 | 1940 | 1950 | 1960 | ||
| KLRRGDMPFV | VTRRIVRKGT | GDCSDEEVDG | KADGADAKAT | E |