Q62780

PR
Gene name
Ddx46 (Hel117)
Protein name
Probable ATP-dependent RNA helicase DDX46
Names
DEAD box protein 46, Helicase of 117.4 kDa
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:245957
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

764-845 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q62780

Entry ID Method Resolution Chain Position Source
AF-Q62780-F1 Predicted AlphaFoldDB

No variants for Q62780

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q62780

No associated diseases with Q62780

5 regional properties for Q62780

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 178 - 186 IPR000629
domain Helicase, C-terminal 243 - 404 IPR001650
domain DEAD/DEAH box helicase domain 56 - 218 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 50 - 247 IPR014001
domain RNA helicase, DEAD-box type, Q motif 31 - 59 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus speckle
  • Nucleus, Cajal body
  • Present in Cajal bodies (CBs) and nuclear speckles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P21372 PRP5 Pre-mRNA-processing ATP-dependent RNA helicase PRP5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q9VNP5 BoYb Putative ATP-dependent RNA helicase BoYb Drosophila melanogaster (Fruit fly) PR
Q9VL52 SoYb Putative ATP-dependent RNA helicase SoYb Drosophila melanogaster (Fruit fly) PR
Q7L014 DDX46 Probable ATP-dependent RNA helicase DDX46 Homo sapiens (Human) PR
Q569Z5 Ddx46 Probable ATP-dependent RNA helicase DDX46 Mus musculus (Mouse) PR
Q5RKI1 Eif4a2 Eukaryotic initiation factor 4A-II Rattus norvegicus (Rat) PR
Q641Y8 Ddx1 ATP-dependent RNA helicase DDX1 Rattus norvegicus (Rat) PR
Q8H0U8 RH42 DEAD-box ATP-dependent RNA helicase 42 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MGRESRHYRK RSASRGRSGS RSRSRSPSDK RSKRGDDRRS RSRDRDRRRE RSRSRDKRRS
70 80 90 100 110 120
RSRDRKRLRR SRSRERDRSR ERRRSRSRDR RRSRSRSRGR RSRSSSPGSK SKKAENRSRS
130 140 150 160 170 180
KEKAEGGDSS KEKKKDKDDK EDEKEKDAGN FDQNKLEEEM RKRKERVEKW REEQRKKAME
190 200 210 220 230 240
NIGELKKEIE EMKQGKKWSL EDDDDDEDDP AEAEKEGNEM EDEELDPLDA YMEEVKEEVK
250 260 270 280 290 300
KFNMRSVKGG AGNEKKSGPT VTKVVTVVTT KKAVVDADKK KGELMENDQD AMEYSSEEEE
310 320 330 340 350 360
VDLQTALTGY QTKQRKLLEP VDHGKIEYEP FRKNFYVEVP ELAKMSQEEV NVFRLEMEGI
370 380 390 400 410 420
TVKGKGCPKP IKSWVQCGIS MKILNSLKKH GYEKPTPIQT QAIPAIMSGR DLIGIAKTGS
430 440 450 460 470 480
GKTIAFLLPM FRHIMDQRSL EEGEGPIAVI MTPTRELALQ ITKECKKFSK TLGLRVVCVY
490 500 510 520 530 540
GGTGISEQIA ELKRGAEIIV CTPGRMIDML AANSGRVTNL RRVTYVVLDE ADRMFDMGFE
550 560 570 580 590 600
PQVMRIVDNV RPDRQTVMFS ATFPRAMEAL ARRILSKPIE VQVGGRSVVC SDVEQQVIVI
610 620 630 640 650 660
EEEKKFLKLL ELLGHYQESG SVIIFVDKQE HADGLLKDLM RASYPCMSLH GGIDQYDRDS
670 680 690 700 710 720
IINDFKNGTC KLLVATSVAA RGLDVKHLIL VVNYSCPNHY EDYVHRAGRT GRAGNKGYAY
730 740 750 760 770 780
TFITEDQARY AGDIIKALEL SGTAVPPDLE KLWSDFKDQQ KAEGKIIKKS SGFSGKGFKF
790 800 810 820 830 840
DETEQALANE RKKLQKAALG LQDSDDEDAA VDIDEQIESM FNSKKRVKDM AAPGTSSAPA
850 860 870 880 890 900
PTAGNAEKLE IAKRLALRIN AQKNLGIESQ VDVMQQATNA ILRGGPLLAP TVSAKTIAEQ
910 920 930 940 950 960
LAEKINAKLN YVPLEKQEEE RQEGGQSESF KRYEEELEIN DFPQTARWKV TSKEALQRIS
970 980 990 1000 1010 1020
EYSEAAITIR GTYFPPGKEP KEGERKIYLA IESANELAVQ KAKAEITRLI KEELIRLQNS
1030
YQPTNKGRYK VL