Q62724
Gene name |
Mcm6 (Mcmd6) |
Protein name |
DNA replication licensing factor MCM6 |
Names |
Intestinal DNA replication protein |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
|
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62724
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62724-F1 | Predicted | AlphaFoldDB |
No variants for Q62724
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62724 | |||||
No associated diseases with Q62724
1 regional properties for Q62724
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | TATA-box binding protein, conserved site | 295 - 344 | IPR030491 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| CMG complex | A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. |
| MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| identical protein binding | Binding to an identical protein or proteins. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
| double-strand break repair via break-induced replication | The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. |
| mitotic DNA replication | Any nuclear DNA replication that is involved in a mitotic cell cycle. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KIZ8 | MCM6 | DNA replication licensing factor MCM6 | Bos taurus (Bovine) | PR |
| Q9V461 | Mcm6 | DNA replication licensing factor Mcm6 | Drosophila melanogaster (Fruit fly) | PR |
| Q14566 | MCM6 | DNA replication licensing factor MCM6 | Homo sapiens (Human) | PR |
| P97311 | Mcm6 | DNA replication licensing factor MCM6 | Mus musculus (Mouse) | PR |
| Q6F353 | Os05g0235800 | DNA replication licensing factor MCM6 | Oryza sativa subsp japonica (Rice) | PR |
| P34647 | mcm-6 | DNA replication licensing factor mcm-6 | Caenorhabditis elegans | PR |
| Q9SF37 | MCM8 | Probable DNA helicase MCM8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28CM3 | mmcm6 | Maternal DNA replication licensing factor mcm6 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6P1V8 | zmcm6 | Zygotic DNA replication licensing factor mcm6 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| LRDEEQTAES | IKNQMTVKEW | EKVFEMSQDQ | NLYHNLCTSL | FPTIHGNDEV | KRGVLLMLFG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVPKTTGEGT | SLRGDINVCI | VGDPSTAKSQ | FLKHVDEFSP | RAVYTSGKAS | SASGLTAAVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RDEESHEFVI | EAGALMLADN | GVCCIDEFDK | MDMRDQVAIH | EAMEQQTISI | TKAGVKATLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARTSILAAAN | PVSGHYDRSK | SLKQNINLSA | PIMSRFDLFF | ILVDECNEVT | DYAIARRIVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHSRIEESID | RVYSLDDIRR | YLLFARQFKP | KISKESEDFI | VEQYKRLRQR | DGSGITKSSW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RITVRQLESM | IRLSESMARM | HCCDEVQPKH | VKEAFRLLNK | SIIRVETPDV | NLDQEEEIQM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETDEGPGGIN | GHADSPAPVN | GFNGSGEDAS | QETVPKPSLR | LAFAEYCRIS | NLIVLHLRKM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EEEEDESALK | RSELVNWYLK | EIESEIDSEE | ELINKKRIIE | KVVHRLTHYD | HVLIELTQAG |
| 490 | 500 | ||||
| LKGSSEGSES | YEEDPYLVVN | PNYLLED |