Q62448
PR
Gene name |
Eif4g2 |
Protein name |
Eukaryotic translation initiation factor 4 gamma 2 |
Names |
eIF-4-gamma 2, eIF-4G 2, eIF4G 2, Novel APOBEC-1 target 1, Translation repressor NAT1, p97 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13690 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62448
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62448-F1 | Predicted | AlphaFoldDB |
No variants for Q62448
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62448 | |||||
No associated diseases with Q62448
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| translation factor activity, RNA binding | Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular macromolecule biosynthetic process | The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. |
| negative regulation of autophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| positive regulation of axon extension | Any process that activates or increases the frequency, rate or extent of axon extension. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| positive regulation of dendritic spine development | Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. |
| positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| regulation of translational initiation | Any process that modulates the frequency, rate or extent of translational initiation. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q41583 | Eukaryotic translation initiation factor isoform 4G-2 | Triticum aestivum (Wheat) | PR | |
| Q95L46 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | Bos taurus (Bovine) | PR |
| Q9H074 | PAIP1 | Polyadenylate-binding protein-interacting protein 1 | Homo sapiens (Human) | PR |
| O43432 | EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 | Homo sapiens (Human) | EV |
| Q04637 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 | Homo sapiens (Human) | EV |
| P78344 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | Homo sapiens (Human) | PR |
| Q8VE62 | Paip1 | Polyadenylate-binding protein-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q80XI3 | Eif4g3 | Eukaryotic translation initiation factor 4 gamma 3 | Mus musculus (Mouse) | SS |
| Q6NZJ6 | Eif4g1 | Eukaryotic translation initiation factor 4 gamma 1 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESAIAEGGA | SRFSASSGGG | GSRGAPQHYP | KTAGNSEFLG | KTPGQNAQKW | IPARSTRRDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSAANNSANE | KERHDAIFRK | VRGILNKLTP | EKFDKLCLEL | LNVGVESKLI | LKGVILLIVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KALEEPKYSS | LYAQLCLRLA | EDAPNFDGPA | AEGQPGQKQS | TTFRRLLISK | LQDEFENRTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVDVYDKREN | PLLPEEEEQR | AIAKIKMLGN | IKFIGELGKL | DLIHESILHK | CIKTLLEKKK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RVQLKDMGED | LECLCQIMRT | VGPRLDHERA | KSLMDQYFAR | MCSLMLSKEL | PARIRFLLQD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TVELREHHWV | PRKAFLDNGP | KTINQIRQDA | VKDLGVFIPA | PMAQGRSDFF | LEGPFMPPRM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KMDRDPLGGL | ADMFGQMPGS | GIGTGPGVIQ | DRFSPTMGRH | RSNQLFNGHG | GHIMPPTQSQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FGEMGGKFMK | SQGLSQLYHN | QSQGLLSQLQ | GQSKDMPPRF | SKKGQLNADE | ISLRPAQSFL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MNKNQVPKLQ | PQITMIPPSA | QPPRTQTPPL | GQTPQLGLKT | NPPLIQEKPA | KTSKKPPPSK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EELLKLTEAV | VTDYLNSGNA | NDAVSGVREM | RAPKHFLPEM | LSKVIILSLD | RSDEDKEKAS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SLISLLKQEG | IATSDNFMQA | FLNVLEQCPK | LEVDIPLVKS | YLAQFAARAI | ISELVSISEL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AQPLESGTHF | PLFLLCLQQL | AKLQDREWLT | ELFQQSKVNM | QKMLPEIDQN | KDRMLEILEG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KGLSFLFPLL | KLEKELLKQI | KLDPSPQTIY | KWIKDNISPK | LHVDKGFVNI | LMTSFLQYIS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SEVSPPSDET | DSSSAPSKEQ | LEQEKQLLLS | FKPVMQKFLH | DHVDLQVSAL | YALQVHCYNS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SFPKGMLLRF | FVHFYDMEII | EEEAFLAWKE | DITQEFPGKG | KALFQVNQWL | TWLETAEEEE |
| SEEEAD |