Q62447
PR
Gene name |
Ccnc |
Protein name |
Cyclin-C |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:51813 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62447
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62447-F1 | Predicted | AlphaFoldDB |
9 variants for Q62447
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388678589 | 70 | K>M | No | EVA | |
| rs1133362340 | 139 | E>K | No | EVA | |
| rs3388673370 | 202 | L>P | No | EVA | |
| rs3388674688 | 225 | E>G | No | EVA | |
| rs3388672550 | 234 | I>N | No | EVA | |
| rs3388672174 | 235 | L>* | No | EVA | |
| rs3388672652 | 235 | L>I | No | EVA | |
| rs3388672652 | 235 | L>V | No | EVA | |
| rs3388677976 | 238 | Y>* | No | EVA |
No associated diseases with Q62447
3 regional properties for Q62447
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclin, N-terminal | 37 - 148 | IPR006671 |
| domain | Cyclin-like domain | 46 - 144 | IPR013763-1 |
| domain | Cyclin-like domain | 157 - 236 | IPR013763-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| identical protein binding | Binding to an identical protein or proteins. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| G0 to G1 transition | The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. |
| negative regulation of Notch signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. |
| negative regulation of triglyceride metabolic process | Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P47821 | SSN8 | RNA polymerase II holoenzyme cyclin-like subunit | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3ZCK5 | CCNC | Cyclin-C | Bos taurus (Bovine) | PR |
| P55168 | CCNC | Cyclin-C | Gallus gallus (Chicken) | PR |
| P25008 | CycC | Cyclin-C | Drosophila melanogaster (Fruit fly) | PR |
| P24863 | CCNC | Cyclin-C | Homo sapiens (Human) | PR |
| Q61458 | Ccnh | Cyclin-H | Mus musculus (Mouse) | PR |
| Q9QWV9 | Ccnt1 | Cyclin-T1 | Mus musculus (Mouse) | SS |
| O88874 | Ccnk | Cyclin-K | Mus musculus (Mouse) | PR |
| P39947 | Ccnc | Cyclin-C | Rattus norvegicus (Rat) | PR |
| Q28F72 | ccnc | Cyclin-C | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGNFWQSSH | YLQWILDKQD | LLKERQKDLK | FLSEEEYWKL | QIFFTNVIQA | LGEHLKLRQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VIATATVYFK | RFYARYSLKS | IDPVLMAPTC | VFLASKVEEF | GVVSNTRLIA | ATTSVLKTRF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYAFPKEFPY | RMNHILECEF | YLLELMDCCL | IVYHPYRPLL | QYVQDMGQED | VLLPLAWRIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NDTYRTDLCL | LYPPFMIALA | CLHVACVVQQ | KDARQWFAEL | SVDMEKILEI | IRVILKLYEQ |
| 250 | 260 | 270 | 280 | ||
| WKNFDERKEM | ATILSKMPKP | KPPPNSEGEQ | GPNGSQNSSY | SQS |