AiPD: Autoinhibited Protein Database

Gene name	Arid3a (Dri1, Dril1)
Protein name	AT-rich interactive domain-containing protein 3A
Names	ARID domain-containing protein 3A, B-cell regulator of IgH transcription, Bright, Dead ringer-like protein 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:13496
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

44-119 (Predicted disordered autoinhibitory region) PR

44-119 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q62431-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs253827874	109	V>I	No	EVA
rs3400982209	177	T>A	No	EVA
rs3401513422	181	F>C	No	EVA
rs3400755273	181	F>L	No	EVA
rs257744800	188	A>T	No	EVA
rs3389114473	236	Q>R	No	EVA
rs3389091040	246	R>M	No	EVA
rs3389086289	249	F>L	No	EVA
rs3389111597	274	V>I	No	EVA
rs3389115850	319	L>I	No	EVA
rs3401375481	346	A>S	No	EVA
rs1132577053	384	P>T	No	EVA
rs3401514708	388	A>T	No	EVA
rs3389111544	409	A>G	No	EVA
rs3389123961	412	I>T	No	EVA
rs3389118413	473	D>G	No	EVA
rs3389118436	508	R>C	No	EVA
rs3389106010	511	S>L	No	EVA
rs3389111600	526	M>I	No	EVA
rs3389123935	530	M>I	No	EVA
rs3389112865	540	F>S	No	EVA
rs1134570651	540	F>V	No	EVA
rs1132123326	541	A>T	No	EVA
rs3401130765	557	V>G	No	EVA
rs224545106	585	P>A	No	EVA
rs238456292	587	V>G	No	EVA
rs261772740	592	M>V	No	EVA
rs864298526	596	S>*	No	EVA
rs864288159	596	S>T	No	EVA
rs3389100816	599	S>P	No	EVA

Type	Name	Position	InterPro Accession
domain	ARID DNA-binding domain	243 - 336	IPR001606
domain	REKLES domain	449 - 546	IPR023334

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Shuttles between nucleus and cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
identical protein binding	Binding to an identical protein or proteins.
transcription coregulator activity	A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

Name	Definition
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q99856	ARID3A	AT-rich interactive domain-containing protein 3A	Homo sapiens (Human)	SS
Q8BM75	Arid5b	AT-rich interactive domain-containing protein 5B	Mus musculus (Mouse)	PR
O02326	cfi-1	AT-rich interactive domain-containing protein cfi-1	Caenorhabditis elegans	PR
C0SUW7	ARID6	AT-rich interactive domain-containing protein 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0WNR6	ARID5	AT-rich interactive domain-containing protein 5	Arabidopsis thaliana (Mouse-ear cress)	PR