Q62419

PR
Gene name
Sh3gl1 (Sh3d2b)
Protein name
Endophilin-A2
Names
Endophilin-2, SH3 domain protein 2B, SH3 domain-containing GRB2-like protein 1, SH3p8
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20405
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

219-341 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q62419

Entry ID Method Resolution Chain Position Source
AF-Q62419-F1 Predicted AlphaFoldDB

11 variants for Q62419

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389465339 23 G>E No EVA
rs3389472228 29 L>P No EVA
rs13468388 35 D>E No EVA
rs3389471732 41 D>N No EVA
rs3389465293 44 S>C No EVA
rs3389488767 87 P>A No EVA
rs3389471669 99 R>G No EVA
rs3411306099 117 A>T No EVA
rs3389488783 142 P>S No EVA
rs3389451351 246 E>D No EVA
rs46615936 292 S>A No EVA

No associated diseases with Q62419

3 regional properties for Q62419

Type Name Position InterPro Accession
conserved_site 14-3-3 protein, conserved site 45 - 55 IPR023409-1
conserved_site 14-3-3 protein, conserved site 217 - 236 IPR023409-2
domain 14-3-3 domain 5 - 249 IPR023410

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Early endosome membrane ; Peripheral membrane protein
  • Cell projection, podosome
  • Associated with postsynaptic endosomes in hippocampal neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane The lipid bilayer surrounding an early endosome.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
hippocampal mossy fiber to CA3 synapse One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
podosome An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
presynapse The part of a synapse that is part of the presynaptic cell.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

8 GO annotations of molecular function

Name Definition
beta-1 adrenergic receptor binding Binding to a beta-1 adrenergic receptor.
GTPase binding Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
identical protein binding Binding to an identical protein or proteins.
lipid binding Binding to a lipid.
phosphatase binding Binding to a phosphatase.
protein C-terminus binding Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

4 GO annotations of biological process

Name Definition
modulation of excitatory postsynaptic potential Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
positive regulation of synaptic vesicle endocytosis Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis.
regulation of synaptic vesicle endocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
synaptic vesicle uncoating The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJA1 SH3GL1 Endophilin-A2 Bos taurus (Bovine) PR
Q8AXU9 SH3GL3 Endophilin-A3 Gallus gallus (Chicken) PR
Q8AXV1 SH3GL2 Endophilin-A1 Gallus gallus (Chicken) PR
Q99963 SH3GL3 Endophilin-A3 Homo sapiens (Human) PR
Q99962 SH3GL2 Endophilin-A1 Homo sapiens (Human) PR
Q99961 SH3GL1 Endophilin-A2 Homo sapiens (Human) PR
Q9Y371 SH3GLB1 Endophilin-B1 Homo sapiens (Human) PR
Q62420 Sh3gl2 Endophilin-A1 Mus musculus (Mouse) PR
Q8BZT2 Sh3rf2 E3 ubiquitin-protein ligase SH3RF2 Mus musculus (Mouse) PR
Q9JK48 Sh3glb1 Endophilin-B1 Mus musculus (Mouse) PR
Q62421 Sh3gl3 Endophilin-A3 Mus musculus (Mouse) PR
Q9JLQ0 Cd2ap CD2-associated protein Mus musculus (Mouse) SS
Q8R550 Sh3kbp1 SH3 domain-containing kinase-binding protein 1 Mus musculus (Mouse) SS
O35180 Sh3gl3 Endophilin-A3 Rattus norvegicus (Rat) PR
O35179 Sh3gl2 Endophilin-A1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKDMEKKV DVTSKAVAEV LVRTIEYLQP
70 80 90 100 110 120
NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMVRH GKELGGESNF GDALLDAGES
130 140 150 160 170 180
MKRLAEVKDS LDIEVKQNFI DPLQNLCDKD LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD
190 200 210 220 230 240
EELRQALEKF EESKEVAETS MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILEELADKL
250 260 270 280 290 300
KRRVREASSR PKREFKPRPR EPFELGELEQ PNGGFPCAPA PKITASSSFR SSDKPIRMPS
310 320 330 340 350 360
KSMPPLDQPS CKALYDFEPE NDGELGFREG DLITLTNQID ENWYEGMLHG QSGFFPLSYV
QVLVPLPQ