Q62413

SS
Gene name
Epha6 (Ehk-2, Ehk2)
Protein name
Ephrin type-A receptor 6
Names
EC 2.7.10.1 , EPH homology kinase 2 , EHK-2
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.

Autoinhibitory domains (AIDs)

604-630 (Juxtamembrane domain) SS

Target domain

630-933 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

814-840 (Activation loop from InterPro)

Target domain

630-943 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for Q62413

Entry ID Method Resolution Chain Position Source
5ZRY X-ray 130 A A/B 957-1035 PDB
AF-Q62413-F1 Predicted AlphaFoldDB

No variants for Q62413

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q62413

No associated diseases with Q62413

No regional properties for Q62413

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q62413

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
transmembrane-ephrin receptor activity Combining with a transmembrane ephrin to initiate a change in cell activity.

3 GO annotations of biological process

Name Definition
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
ephrin receptor signaling pathway The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

49 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P28693 EPHB2 Ephrin type-B receptor 2 Gallus gallus (Chicken) PR
Q07496 EPHA4 Ephrin type-A receptor 4 Gallus gallus (Chicken) SS
Q07494 EPHB1 Ephrin type-B receptor 1 Gallus gallus (Chicken) SS
Q07497 EPHB5 Ephrin type-B receptor 5 Gallus gallus (Chicken) PR
P29318 EPHA3 Ephrin type-A receptor 3 Gallus gallus (Chicken) SS
O42422 EPHA7 Ephrin type-A receptor 7 Gallus gallus (Chicken) SS
P54755 EPHA5 Ephrin type-A receptor 5 Gallus gallus (Chicken) SS
Q07498 EPHB3 Ephrin type-B receptor 3 Gallus gallus (Chicken) SS
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P29322 EPHA8 Ephrin type-A receptor 8 Homo sapiens (Human) SS
P21709 EPHA1 Ephrin type-A receptor 1 Homo sapiens (Human) SS
P54764 EPHA4 Ephrin type-A receptor 4 Homo sapiens (Human) SS
P54753 EPHB3 Ephrin type-B receptor 3 Homo sapiens (Human) SS
P29320 EPHA3 Ephrin type-A receptor 3 Homo sapiens (Human) PR
P54760 EPHB4 Ephrin type-B receptor 4 Homo sapiens (Human) SS
P29317 EPHA2 Ephrin type-A receptor 2 Homo sapiens (Human) SS
Q15375 EPHA7 Ephrin type-A receptor 7 Homo sapiens (Human) SS
Q5JZY3 EPHA10 Ephrin type-A receptor 10 Homo sapiens (Human) SS
P29323 EPHB2 Ephrin type-B receptor 2 Homo sapiens (Human) EV
P54762 EPHB1 Ephrin type-B receptor 1 Homo sapiens (Human) SS
P54756 EPHA5 Ephrin type-A receptor 5 Homo sapiens (Human) SS
O15197 EPHB6 Ephrin type-B receptor 6 Homo sapiens (Human) SS
Q9UF33 EPHA6 Ephrin type-A receptor 6 Homo sapiens (Human) SS
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
O08644 Ephb6 Ephrin type-B receptor 6 Mus musculus (Mouse) PR
O09127 Epha8 Ephrin type-A receptor 8 Mus musculus (Mouse) SS
P54754 Ephb3 Ephrin type-B receptor 3 Mus musculus (Mouse) SS
P54763 Ephb2 Ephrin type-B receptor 2 Mus musculus (Mouse) SS
Q03137 Epha4 Ephrin type-A receptor 4 Mus musculus (Mouse) SS
Q61772 Epha7 Ephrin type-A receptor 7 Mus musculus (Mouse) SS
Q8BYG9 Epha10 Ephrin type-A receptor 10 Mus musculus (Mouse) SS
Q8CBF3 Ephb1 Ephrin type-B receptor 1 Mus musculus (Mouse) SS
P29319 Epha3 Ephrin type-A receptor 3 Mus musculus (Mouse) SS
P54757 Epha5 Ephrin type-A receptor 5 Rattus norvegicus (Rat) SS
P54759 Epha7 Ephrin type-A receptor 7 Rattus norvegicus (Rat) SS
P09759 Ephb1 Ephrin type-B receptor 1 Rattus norvegicus (Rat) SS
P0C0K7 Ephb6 Ephrin type-B receptor 6 Rattus norvegicus (Rat) SS
O08680 Epha3 Ephrin type-A receptor 3 Rattus norvegicus (Rat) SS
O61460 vab-1 Ephrin receptor 1 Caenorhabditis elegans SS
Q9LMN7 WAK5 Wall-associated receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSV3 WAKL16 Putative wall-associated receptor kinase-like 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M342 WAKL15 Wall-associated receptor kinase-like 15 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZJ9 CRCK2 Calmodulin-binding receptor-like cytoplasmic kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
O13147 ephb3 Ephrin type-B receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73878 ephb4b Ephrin type-B receptor 4b Danio rerio (Zebrafish) (Brachydanio rerio) SS
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGGCEVREFL LQFGFFLPLL TAWTGDCSHV SNQVVLLDTT TVMGELGWKT YPLNGWDAIT
70 80 90 100 110 120
EMDEHNRPIH TYQVCNVMEP NQNNWLRTNW ISRDAAQKIY VEMKFTLRDC NSIPWVLGTC
130 140 150 160 170 180
KETFNLYYIE SDESHGTKFK PSQYIKIDTI AADESFTQMD LGDRILKLNT EIREVGPIER
190 200 210 220 230 240
KGFYLAFQDI GACIALVSVR VFYKKCPFTV RNLAMFPDTI PRVDSSSLVE VRGSCVKSAE
250 260 270 280 290 300
ERDTPKLYCG ADGDWLVPLG RCICSTGYEE IEGSCHACRP GFYKAFAGNT KCSKCPPHSS
310 320 330 340 350 360
TYVEATSVCH CEKGYFRAEK DPPSMACTRP PSAPRNVAFN INETALILEW SPPSDTGGRK
370 380 390 400 410 420
DLTYSVICKK CGLDTTQCED CGGGLRFIPR HTGLINNSVV VLDFVSHVNY TFEIEAMNGV
430 440 450 460 470 480
SELSISPKPF TAITVTTDHD APSLIGMMRK DWASQNSLAL SWQAPAFSNG AILDYEIKYY
490 500 510 520 530 540
EKEHEQLTYS STRSKAPSVI VTGLKPATTY IFHIRVRTAT GYSGYSQKFE FETGDETSDM
550 560 570 580 590 600
AAEQGQILVI ATAAVGGFTL LVILTLFFLI TGRCQWYIKA KMKSEEKRRT HLQNGHLRFP
610 620 630 640 650 660
GIKTYIDPDT YEDPSLAVHE FAKEIDPSRI RIERVIGAGE FGEVCSGRLK TPGKREIPVA
670 680 690 700 710 720
IKTLKGGHMD RQRRDFLREA SIMGQFDHPN IIRLEGVVTK RSFPAIGVEA FCPSFLRAGF
730 740 750 760 770 780
LNGIQAPHPV TAGGSLPPRI PAGRPVMIVV EYMENGSLDS FLRKHDGHFT VIQLVGMLRG
790 800 810 820 830 840
IASGMKYLSD MGYVHRDLAA RNILVNSNLV CKVSDFGLSR VLEDDPEAAY TTTGGKIPIR
850 860 870 880 890 900
WTAPEAIAYR KFSSASDAWS YGIVMWEVMS YGERPYWEMS NQDVILSIEE GYRLPAPMGC
910 920 930 940 950 960
PPSLHQLMLH CWQKERNHRP KFTDIVSFLD KLIRNPSALH TLVEDILVMP ESPGDVPEYP
970 980 990 1000 1010 1020
LFVTVGDWLD SIKMGQYKSN FMAAGFTTFD LISRMSIDDI RRIGVILIGH QRRIVSSIQT
1030
LRLHMMHIQE KGFHV