Q62245

SS
Gene name
Sos1
Protein name
Son of sevenless homolog 1
Names
SOS-1 , mSOS-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20662
EC number
Protein Class

Descriptions

The translocation of Son of Sevenless 1 (SOS1) protein to the plasma membrane enables activation of membrane-bound Ras, which is a vital regulator of cell proliferation and differentiation. The autoinhibitory conformation of SOS1 consists of the histone domain, the Dbl homology (DH), the Pleckstrin homology (PH) domain, and PH-Rem helical linker. SOS is inactive by the DH-PH unit, which blocks allosteric Ras binding. In addition, the histone domain plays a dual role in occluding the allosteric site and in stabilizing the autoinhibitory conformation of the DH-PH unit. Autoinhibition of the catalytic domain of SOS is released by enhancing the density of PIP2 and the local concentration of Ras-GTP, consequently increasing the activity of SOS at the membrane.

Autoinhibitory domains (AIDs)

200-390 (DH domain) SS

Target domain

776-1020 (Ras guanine-nucleotide exchange factors catalytic domain)

Relief mechanism

Partner binding

Assay

443-548 (PH domain) SS

Target domain

776-1020 (Ras guanine-nucleotide exchange factors catalytic domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q62245

Entry ID Method Resolution Chain Position Source
1B07 X-ray 250 A C 1135-1144 PDB
1GBQ NMR - B 1135-1144 PDB
1PMS NMR - A 414-548 PDB
2GBQ NMR - B 1135-1144 PDB
3GBQ NMR - B 1135-1144 PDB
4GBQ NMR - B 1135-1144 PDB
AF-Q62245-F1 Predicted AlphaFoldDB

68 variants for Q62245

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389489700 59 L>Q No EVA
rs3389429981 94 I>F No EVA
rs3389477284 101 N>K No EVA
rs3389489745 138 S>C No EVA
rs3389480800 160 Q>P No EVA
rs3389482935 180 V>E No EVA
rs3408084830 213 R>L No EVA
rs3389477257 265 D>V No EVA
rs3389477306 320 A>V No EVA
rs3389477285 322 L>F No EVA
rs3389473738 334 A>T No EVA
rs3389483009 347 V>M No EVA
rs864299442 352 H>Q No EVA
rs3389440036 352 H>Y No EVA
rs3389477288 354 F>L No EVA
rs1134521164 370 K>* No EVA
rs1133394635 377 I>V No EVA
rs1134692085 382 N>I No EVA
rs3389494776 420 K>N No EVA
rs3389440100 426 Q>* No EVA
rs3389482987 433 E>D No EVA
rs3389480757 434 G>E No EVA
rs221516702 485 S>T No EVA
rs3389440072 540 A>V No EVA
rs3389483168 541 L>V No EVA
rs3408199792 549 T>I No EVA
rs3407404440 553 M>V No EVA
rs260206898 566 Q>H No EVA
rs3389473766 566 Q>L No EVA
rs3389392422 637 P>L No EVA
rs3389485279 639 E>D No EVA
rs3389477280 639 E>G No EVA
rs3389440107 717 F>S No EVA
rs3389440032 733 I>T No EVA
rs3408042947 753 T>A No EVA
rs3406196557 754 F>C No EVA
rs3408042999 758 P>T No EVA
rs3389462147 760 T>I No EVA
rs3389483147 762 E>K No EVA
rs3406196617 763 W>* No EVA
rs3406196587 764 H>Q No EVA
rs3389482934 772 E>D No EVA
rs3389475491 798 A>G No EVA
rs3389462088 816 I>N No EVA
rs3389448521 851 V>L No EVA
rs3389430002 864 E>* No EVA
rs3408084869 869 N>H No EVA
rs3408084831 871 V>L No EVA
rs3389429979 875 V>L No EVA
rs3389429961 877 A>D No EVA
rs3389498944 887 D>Y No EVA
rs3389462081 950 R>G No EVA
rs3389429990 960 K>N No EVA
rs3389477311 976 N>K No EVA
rs3389392436 1000 S>C No EVA
rs249950894 1020 H>P No EVA
rs3389462110 1036 K>N No EVA
rs3389477348 1038 P>R No EVA
rs3389440065 1052 H>Y No EVA
rs3389485269 1068 I>T No EVA
rs3389482969 1128 K>E No EVA
rs864269837 1136 P>A No EVA
rs3389392404 1185 S>P No EVA
rs3389392368 1195 E>D No EVA
rs3413061824 1221 P>S No EVA
rs3389477312 1237 N>K No EVA
rs3407686333 1261 S>* No EVA
rs3389429980 1277 P>R No EVA

No associated diseases with Q62245

5 regional properties for Q62245

Type Name Position InterPro Accession
domain Dbl homology (DH) domain 200 - 390 IPR000219
domain Ras-like guanine nucleotide exchange factor, N-terminal 596 - 741 IPR000651
domain Pleckstrin homology domain 443 - 548 IPR001849
domain Ras guanine-nucleotide exchange factors catalytic domain 776 - 1020 IPR001895
conserved_site Ras guanine-nucleotide exchange factor, conserved site 927 - 960 IPR019804

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GTPase complex A protein complex which is capable of GTPase activity.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
epidermal growth factor receptor binding Binding to an epidermal growth factor receptor.
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
molecular condensate scaffold activity Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

33 GO annotations of biological process

Name Definition
B cell homeostasis The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
blood vessel morphogenesis The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
cardiac atrium morphogenesis The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
epidermal growth factor receptor signaling pathway The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
ERBB2-ERBB3 signaling pathway The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission.
eyelid development in camera-type eye The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.
fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
hair follicle development The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
heart morphogenesis The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
heart trabecula morphogenesis The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
insulin-like growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
midbrain morphogenesis The developmental process by which a midbrain is generated and organized.
multicellular organism growth The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
neurotrophin TRK receptor signaling pathway The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
pericardium morphogenesis The process in which the anatomical structure of the pericardium is generated and organized.
positive regulation of epidermal growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
positive regulation of Ras protein signal transduction Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
positive regulation of small GTPase mediated signal transduction Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of pro-B cell differentiation Any process that modulates the frequency, rate or extent of pro-B cell differentiation.
regulation of T cell differentiation in thymus Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus.
regulation of T cell proliferation Any process that modulates the frequency, rate or extent of T cell proliferation.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to ischemia Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
roof of mouth development The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
Schwann cell development The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
small GTPase-mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
vitellogenesis The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6N9I4 RASGRP2 RAS guanyl-releasing protein 2 Bos taurus (Bovine) SS
Q1LZ97 RASGRP4 RAS guanyl-releasing protein 4 Bos taurus (Bovine) SS
A0A3S5ZPR1 RASGRP3 RAS guanyl releasing protein 3 Gallus gallus (Chicken) SS
P26675 Sos Protein son of sevenless Drosophila melanogaster (Fruit fly) SS
Q5JS13 RALGPS1 Ras-specific guanine nucleotide-releasing factor RalGPS1 Homo sapiens (Human) PR
O95267 RASGRP1 RAS guanyl-releasing protein 1 Homo sapiens (Human) EV
Q7LDG7 RASGRP2 RAS guanyl-releasing protein 2 Homo sapiens (Human) EV SS
Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 Homo sapiens (Human) PR
Q8IV61 RASGRP3 Ras guanyl-releasing protein 3 Homo sapiens (Human) SS
Q8TDF6 RASGRP4 RAS guanyl-releasing protein 4 Homo sapiens (Human) SS
Q07890 SOS2 Son of sevenless homolog 2 Homo sapiens (Human) SS
Q13905 RAPGEF1 Rap guanine nucleotide exchange factor 1 Homo sapiens (Human) PR
Q07889 SOS1 Son of sevenless homolog 1 Homo sapiens (Human) EV
Q02384 Sos2 Son of sevenless homolog 2 Mus musculus (Mouse) SS
Q9Z1S3 Rasgrp1 RAS guanyl-releasing protein 1 Mus musculus (Mouse) SS
Q8VCC8 Rapgef3 Rap guanine nucleotide exchange factor 3 Mus musculus (Mouse) SS
Q9EQZ6 Rapgef4 Rap guanine nucleotide exchange factor 4 Mus musculus (Mouse) EV
Q9D300 Rasgef1c Ras-GEF domain-containing family member 1C Mus musculus (Mouse) PR
Q03385 Ralgds Ral guanine nucleotide dissociation stimulator Mus musculus (Mouse) PR
Q8BTM9 Rasgrp4 RAS guanyl-releasing protein 4 Mus musculus (Mouse) SS
Q9QUG9 Rasgrp2 RAS guanyl-releasing protein 2 Mus musculus (Mouse) SS
Q9ERD6 Ralgps2 Ras-specific guanine nucleotide-releasing factor RalGPS2 Mus musculus (Mouse) PR
A2AR50 Ralgps1 Ras-specific guanine nucleotide-releasing factor RalGPS1 Mus musculus (Mouse) PR
Q9R1K8 Rasgrp1 RAS guanyl-releasing protein 1 Rattus norvegicus (Rat) SS
P0C643 Rasgrp2 RAS guanyl-releasing protein 2 Rattus norvegicus (Rat) SS
Q8R5I4 Rasgrp4 RAS guanyl-releasing protein 4 Rattus norvegicus (Rat) SS
Q9N5D3 sos-1 Son of sevenless homolog Caenorhabditis elegans EV
A4IJ06 rasgrp1 RAS guanyl-releasing protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC
70 80 90 100 110 120
QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPAERI HHLLREVLGY
130 140 150 160 170 180
KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV
190 200 210 220 230 240
EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN
250 260 270 280 290 300
DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR
310 320 330 340 350 360
DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL
370 380 390 400 410 420
EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK
430 440 450 460 470 480
KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL
490 500 510 520 530 540
PGASSAEYRL KEKFFMRKVQ INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA
550 560 570 580 590 600
LISLQYRSTL ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI
610 620 630 640 650 660
IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI PEPEPTEADR
670 680 690 700 710 720
IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDADL LQRMEEFIGT
730 740 750 760 770 780
VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH
790 800 810 820 830 840
PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV
850 860 870 880 890 900
ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI
910 920 930 940 950 960
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR HGKELINFSK
970 980 990 1000 1010 1020
RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRH
1030 1040 1050 1060 1070 1080
PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP
1090 1100 1110 1120 1130 1140
NSPRTPLTPP PASGTSSNTD VCSVFDSDHS ASPFHSRSAS VSSISLSKGT DEVPVPPPVP
1150 1160 1170 1180 1190 1200
PRRRPESAPA ESSPSKIMSK HLDSPPAIPP RQPTSKAYSP RYSISDRTSI SDPPESPPLL
1210 1220 1230 1240 1250 1260
PPREPVRTPD VFSSSPLHLQ PPPLGKKSDH GNAFFPNSPS PFTPPPPQTP SPHGTRRHLP
1270 1280 1290 1300 1310
SPPLTQEMDL HSIAGPPVPP RQSTSQLIPK LPPKTYKREH THPSMHRDGP PLLENAHSS