Q62095

SS
Gene name
Ddx3y (D1Pas1-rs1, Dead2)
Protein name
ATP-dependent RNA helicase DDX3Y
Names
EC 3.6.4.13 , D1Pas1-related sequence 1 , DEAD box protein 3, Y-chromosomal , DEAD-box RNA helicase DEAD2 , mDEAD2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26900
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

DEAD-box proteins utilize ATP to bind and remodel RNA and RNA-protein complexes. The Ded1/DDX3 subfamily of DEAD-box proteins is of particular interest as their function during protein translation, are essential for viability, and are frequently altered in human malignancies. <br>There is a unique interdomain interaction between the two ATPase domains (DEAD box helicase domain and helicase domain) in which the C-terminal helicase domain clashes with the RNA-binding surface. Destabilizing this interaction accelerates RNA duplex unwinding, suggesting that it is present in solution and inhibitory for catalysis. The N-terminal extension to the DEAD box helicase interacts with DEAD box helicase domain and C-terminal helicase domain, and stabilizes the autoinhibited state of DDX3X.

Autoinhibitory domains (AIDs)

413-574 (C-terminal helicase domain) SS

Target domain

203-390 (DEAD box helicase domain)

Relief mechanism

Assay

203-390 (DEAD box helicase domain) SS

Target domain

413-574 (C-terminal helicase domain)

Relief mechanism

Assay

131-181 (N-terminal extension) SS

Target domain

203-390 (DEAD box helicase domain);413-574 (C-terminal helicase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q62095

Entry ID Method Resolution Chain Position Source
AF-Q62095-F1 Predicted AlphaFoldDB

16 variants for Q62095

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3412699723 42 P>S No EVA
rs3412854196 43 H>L No EVA
rs3411907211 57 D>N No EVA
rs3412976176 178 I>T No EVA
rs3412617409 252 A>T No EVA
rs3412289521 290 Y>C No EVA
rs3412585907 291 R>P No EVA
rs3411334483 343 L>S No EVA
rs3412617439 372 K>Q No EVA
rs3411334499 483 L>P No EVA
rs3410023185 488 S>P No EVA
rs3412784235 489 G>E No EVA
rs3412673478 563 K>N No EVA
rs3412976162 569 W>C No EVA
rs3412497038 658 N>T No EVA
rs3410023187 659 N>E No EVA

No associated diseases with Q62095

No regional properties for Q62095

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q62095

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gamete generation The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5W5U4 DDX4 Probable ATP-dependent RNA helicase DDX4 Bos taurus (Bovine) SS
Q6GVM6 DDX3Y ATP-dependent RNA helicase DDX3Y Pan troglodytes (Chimpanzee) SS
Q9NQI0 DDX4 Probable ATP-dependent RNA helicase DDX4 Homo sapiens (Human) SS
O15523 DDX3Y ATP-dependent RNA helicase DDX3Y Homo sapiens (Human) SS
O00571 DDX3X ATP-dependent RNA helicase DDX3X Homo sapiens (Human) EV
P16381 D1Pas1 Putative ATP-dependent RNA helicase Pl10 Mus musculus (Mouse) SS
Q61496 Ddx4 ATP-dependent RNA helicase DDX4 Mus musculus (Mouse) SS
Q62167 Ddx3x ATP-dependent RNA helicase DDX3X Mus musculus (Mouse) SS
Q99MJ9 Ddx50 ATP-dependent RNA helicase DDX50 Mus musculus (Mouse) PR
Q91VC3 Eif4a3 Eukaryotic initiation factor 4A-III Mus musculus (Mouse) PR
Q9Z1N5 Ddx39b Spliceosome RNA helicase Ddx39b Mus musculus (Mouse) PR
Q9QY15 Ddx25 ATP-dependent RNA helicase DDX25 Mus musculus (Mouse) PR
Q61655 Ddx19a ATP-dependent RNA helicase DDX19A Mus musculus (Mouse) SS
Q501J6 Ddx17 Probable ATP-dependent RNA helicase DDX17 Mus musculus (Mouse) PR
Q8VDW0 Ddx39a ATP-dependent RNA helicase DDX39A Mus musculus (Mouse) PR
Q91VN6 Ddx41 Probable ATP-dependent RNA helicase DDX41 Mus musculus (Mouse) PR
Q61656 Ddx5 Probable ATP-dependent RNA helicase DDX5 Mus musculus (Mouse) PR
Q6GWX0 DDX4 Probable ATP-dependent RNA helicase DDX4 Sus scrofa (Pig) SS
Q2R1M8 Os11g0599500 DEAD-box ATP-dependent RNA helicase 52C Oryza sativa subsp. japonica (Rice) SS
Q6Z4K6 PL10B DEAD-box ATP-dependent RNA helicase 52B Oryza sativa subsp. japonica (Rice) SS
Q75HJ0 PL10A DEAD-box ATP-dependent RNA helicase 37 Oryza sativa subsp. japonica (Rice) SS
O01836 glh-3 ATP-dependent RNA helicase glh-3 Caenorhabditis elegans PR
D0PV95 laf-1 ATP-dependent RNA helicase laf-1 Caenorhabditis elegans SS
Q84W89 RH37 DEAD-box ATP-dependent RNA helicase 37 Arabidopsis thaliana (Mouse-ear cress) SS
Q8LA13 RH11 DEAD-box ATP-dependent RNA helicase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2F9 RH52 DEAD-box ATP-dependent RNA helicase 52 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MSQVAAESTA GLDQQFVGLD LKSSDNQNGG GNTESKGRYI PPHLRNRETS KGVCDKDSSG
70 80 90 100 110 120
WSCSKDKDAY SSFGSRDSRG KPNYFSDRGS GSRGRFDDHG RNDYDGIGGR DRTGFGKFER
130 140 150 160 170 180
SGHSRWSDRS DEDDWSKPLP PSERLEQELF SGGNTGINFE KYDDIPVEAT GNNCPPHIEN
190 200 210 220 230 240
FSDIEMGEII MGNIELTRYT RPTPVQKHAI PIIKEKRDLM ACAQTGSGKT AAFLLPILSQ
250 260 270 280 290 300
IYTDGPGEAL KAMKENGRYG RRKQYPISLV LAPTRELAVQ IYEEARKFSY RSRVRPCVVY
310 320 330 340 350 360
GGADTVQQIR DLERGCHLLV ATPGRLVDMM ERGKIGLDFC KYLVLDEADR MLDMGFEPQI
370 380 390 400 410 420
RRIVEQDTMP PKGVRHTMMF SATFPKEIQM LARDFLDEYI FLAVGRVGST SENITQKVVW
430 440 450 460 470 480
VEELDKRSFL LDLLNATGKD SLTLVFVETK KGADSLENFL FQERYACTSI HGDRSQKDRE
490 500 510 520 530 540
EALHQFRSGR KPILVATAVA ARGLDISNVK HVINFDLPSD IEEYVHRIGR TGRVGNLGLA
550 560 570 580 590 600
TSFFNERNLN ITKDLLDLLV EAKQEVPSWL ESMAYEHHYK GSSRGRSKSR FSGGFGARDY
610 620 630 640 650
RQSSGSANAG FNSNRANSSR SSGSSHNRGF GGGGYGGFYN NDGYGGNYNS QAVDWWGN