Q61881
PR
Gene name |
Mcm7 (Cdc47, Mcmd7) |
Protein name |
DNA replication licensing factor MCM7 |
Names |
CDC47 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17220 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61881
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61881-F1 | Predicted | AlphaFoldDB |
38 variants for Q61881
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388801573 | 77 | F>L | No | EVA | |
| rs3388807476 | 77 | F>V | No | EVA | |
| rs13472223 | 96 | K>E | No | EVA | |
| rs1131872226 | 127 | P>S | No | EVA | |
| rs1135112448 | 139 | R>* | No | EVA | |
| rs1132880489 | 140 | G>S | No | EVA | |
| rs3396124882 | 204 | I>M | No | EVA | |
| rs3388774233 | 208 | S>G | No | EVA | |
| rs3388783213 | 246 | V>A | No | EVA | |
| rs3388793675 | 256 | V>A | No | EVA | |
| rs3388791564 | 274 | T>I | No | EVA | |
| rs49490206 | 310 | D>E | No | EVA | |
| rs3388804101 | 317 | G>R | No | EVA | |
| rs3388797832 | 388 | S>Y | No | EVA | |
| rs3388788307 | 395 | D>N | No | EVA | |
| rs3388801659 | 396 | R>S | No | EVA | |
| rs3388801945 | 407 | R>H | No | EVA | |
| rs3388796589 | 416 | A>T | No | EVA | |
| rs3388796637 | 417 | A>T | No | EVA | |
| rs48641288 | 426 | E>D | No | EVA | |
| rs3388796604 | 431 | G>D | No | EVA | |
| rs3395577692 | 436 | L>P | No | EVA | |
| rs3388783176 | 438 | D>N | No | EVA | |
| rs3388807508 | 451 | A>P | No | EVA | |
| rs3388797853 | 462 | M>V | No | EVA | |
| rs3388801916 | 483 | S>F | No | EVA | |
| rs221813707 | 505 | V>I | No | EVA | |
| rs3388783242 | 547 | P>T | No | EVA | |
| rs3396335771 | 558 | L>V | No | EVA | |
| rs3388803625 | 575 | E>D | No | EVA | |
| rs3388797849 | 583 | A>T | No | EVA | |
| rs3388809033 | 586 | V>A | No | EVA | |
| rs3395902866 | 592 | A>V | No | EVA | |
| rs3396325364 | 598 | A>G | No | EVA | |
| rs3396439614 | 602 | S>A | No | EVA | |
| rs3395577660 | 605 | T>A | No | EVA | |
| rs3388799072 | 625 | V>A | No | EVA | |
| rs3388771579 | 634 | I>L | No | EVA |
No associated diseases with Q61881
6 regional properties for Q61881
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MCM domain | 322 - 541 | IPR001208 |
| domain | AAA+ ATPase domain | 373 - 526 | IPR003593 |
| conserved_site | Mini-chromosome maintenance, conserved site | 440 - 448 | IPR018525 |
| domain | MCM N-terminal domain | 10 - 139 | IPR027925 |
| domain | MCM OB domain | 149 - 278 | IPR033762 |
| domain | MCM, AAA-lid domain | 558 - 640 | IPR041562 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| CMG complex | A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| cellular response to epidermal growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. |
| cellular response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| DNA strand elongation involved in DNA replication | The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. |
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
| double-strand break repair via break-induced replication | The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. |
| regulation of DNA-templated DNA replication initiation | Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. |
| regulation of phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZBH9 | MCM7 | DNA replication licensing factor MCM7 | Bos taurus (Bovine) | PR |
| Q9XYU0 | Mcm7 | DNA replication licensing factor Mcm7 | Drosophila melanogaster (Fruit fly) | PR |
| P33993 | MCM7 | DNA replication licensing factor MCM7 | Homo sapiens (Human) | PR |
| P97311 | Mcm6 | DNA replication licensing factor MCM6 | Mus musculus (Mouse) | PR |
| P97310 | Mcm2 | DNA replication licensing factor MCM2 | Mus musculus (Mouse) | PR |
| Q6NX31 | mcm7 | DNA replication licensing factor mcm7 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALKDYAIEK | EKVKKFLQEF | YYENELGKKQ | FKYGTQLVHL | AHREQVALYV | DLDDIAEDDP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELVDSICENA | KRYSRLFGDV | VQELLPEYKE | KEVVNKDVLD | VYIEHRLMME | QRSRDPGAVR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPQNQYPSEL | MRRFELYFRG | PSSSKPRVIR | EVRADSVGKL | LTVRGIVTRV | SEVKPRMVVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TYTCDQCGAE | TYQPIQSPTF | MPLIMCPSQE | CQTNRSGGRL | YLQTRGSKFV | KFQEMKIQEH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDQVPVGNIP | RSITVVLEGE | NTRIAQPGDH | VSVTGIFLPV | LRTGFQQMAQ | GLLSETYLEA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HWIVKMTKSD | DDVSGAGELS | SEELKQIAEE | DFYEKLAASI | APEIYGHEDV | KKALLLLLVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GVDQSPQGMK | IRGNIHICLM | GDPGVAKSQL | LSYIDRLAPR | SQYTTGRGSS | GVGLTAAVLR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DSVSGELTLE | GGALVLADQG | VCCIDEFDKM | AEADRTAIHE | VMEQQTISIA | KAGILTTLNA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RCSILAAANP | AYGRYNPRRS | LEQNVQLPAA | LLSRFDLLWL | IQDRPDRDND | LRLAQHITYV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HQHSRQPPAQ | FEPLDMKLMR | RYIAMCHERQ | PTVPESLADY | ITAAYVEMRR | EARASKDATY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TSARTLLAIL | RLSTALARLR | MVDIVEKEDV | NEAIRLMEMS | KDSLLGEKGQ | TARTQRPADV |
| 670 | 680 | 690 | 700 | 710 | |
| IFATIRELVS | RGRSVHFSEA | EQRCISRGFT | PAQFQAALDE | YEELNVWQVN | TSRTRITFV |