Q61656
PR
Gene name |
Ddx5 (Tnz2) |
Protein name |
Probable ATP-dependent RNA helicase DDX5 |
Names |
DEAD box RNA helicase DEAD1, mDEAD1, DEAD box protein 5, RNA helicase p68 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61656
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61656-F1 | Predicted | AlphaFoldDB |
No variants for Q61656
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q61656 | |||||
No associated diseases with Q61656
7 regional properties for Q61656
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 246 - 254 | IPR000629 |
| domain | Helicase, C-terminal | 327 - 475 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 118 - 288 | IPR011545 |
| repeat | RNA helicase p68 repeat | 498 - 532 | IPR012587-1 |
| repeat | RNA helicase p68 repeat | 551 - 583 | IPR012587-2 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 113 - 316 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 94 - 122 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
17 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| MH2 domain binding | Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. |
| mRNA 3'-UTR binding | Binding to a 3' untranslated region of an mRNA molecule. |
| nuclear androgen receptor binding | Binding to a nuclear androgen receptor. |
| pre-mRNA binding | Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
| primary miRNA binding | Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. |
| promoter-specific chromatin binding | Binding to a section of chromatin that is associated with gene promoter sequences of DNA. |
| R-SMAD binding | Binding to a receptor-regulated SMAD signaling protein. |
| ribonucleoprotein complex binding | Binding to a complex of RNA and protein. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| SMAD binding | Binding to a SMAD signaling protein. |
| transcription coregulator activity | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| alternative mRNA splicing, via spliceosome | The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
| androgen receptor signaling pathway | The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| BMP signaling pathway | The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| epithelial to mesenchymal transition | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| intracellular estrogen receptor signaling pathway | The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| intrinsic apoptotic signaling pathway by p53 class mediator | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. |
| miRNA transcription | The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation. |
| mRNA transcription | The cellular synthesis of messenger RNA (mRNA) from a DNA template. |
| myoblast differentiation | The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| nuclear-transcribed mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. |
| positive regulation of DNA damage response, signal transduction by p53 class mediator | Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of miRNA maturation | Any process that activates or increases the frequency, rate or extent of maturation of miRNAs. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| regulation of alternative mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
| regulation of androgen receptor signaling pathway | Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. |
| regulation of osteoblast differentiation | Any process that modulates the frequency, rate or extent of osteoblast differentiation. |
| regulation of skeletal muscle cell differentiation | Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of viral genome replication | Any process that modulates the frequency, rate or extent of viral genome replication. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2NL08 | DDX55 | ATP-dependent RNA helicase DDX55 | Bos taurus (Bovine) | PR |
| Q8NHQ9 | DDX55 | ATP-dependent RNA helicase DDX55 | Homo sapiens (Human) | PR |
| P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | Homo sapiens (Human) | PR |
| Q6ZPL9 | Ddx55 | ATP-dependent RNA helicase DDX55 | Mus musculus (Mouse) | PR |
| Q501J6 | Ddx17 | Probable ATP-dependent RNA helicase DDX17 | Mus musculus (Mouse) | PR |
| Q99MJ9 | Ddx50 | ATP-dependent RNA helicase DDX50 | Mus musculus (Mouse) | PR |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q91VC3 | Eif4a3 | Eukaryotic initiation factor 4A-III | Mus musculus (Mouse) | PR |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q9QY15 | Ddx25 | ATP-dependent RNA helicase DDX25 | Mus musculus (Mouse) | PR |
| Q61655 | Ddx19a | ATP-dependent RNA helicase DDX19A | Mus musculus (Mouse) | SS |
| Q91VN6 | Ddx41 | Probable ATP-dependent RNA helicase DDX41 | Mus musculus (Mouse) | PR |
| Q0E2Z7 | Os02g0201900 | DEAD-box ATP-dependent RNA helicase 41 | Oryza sativa subsp japonica (Rice) | PR |
| Q5QMN3 | Os01g0197200 | DEAD-box ATP-dependent RNA helicase 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N7W4 | Os01g0911100 | DEAD-box ATP-dependent RNA helicase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q56X76 | RH39 | DEAD-box ATP-dependent RNA helicase 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSYSSDRDR | GRDRGFGAPR | FGGSRTGPLS | GKKFGNPGEK | LVKKKWNLDE | LPKFEKNFYQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EHPDLARRTA | QEVDTYRRSK | EITVRGHNCP | KPVLNFYEAN | FPANVMDVIA | RQNFTEPTAI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QAQGWPVALS | GLDMVGVAQT | GSGKTLSYLL | PAIVHINHQP | FLERGDGPIC | LVLAPTRELA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QQVQQVAAEY | CRACRLKSTC | IYGGAPKGPQ | IRDLERGVEI | CIATPGRLID | FLECGKTNLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RTTYLVLDEA | DRMLDMGFEP | QIRKIVDQIR | PDRQTLMWSA | TWPKEVRQLA | EDFLKDYIHI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NIGALELSAN | HNILQIVDVC | HDVEKDEKLI | RLMEEIMSEK | ENKTIVFVET | KRRCDELTRK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MRRDGWPAMG | IHGDKSQQER | DWVLNEFKHG | KAPILIATDV | ASRGLDVEDV | KFVINYDYPN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSEDYIHRIG | RTARSTKTGT | AYTFFTPNNI | KQVSDLISVL | REANQAINPK | LLQLVEDRGS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GRSRGRGGMK | DDRRDRYSAG | KRGGFNTFRD | RENYDRGYSN | LLKRDFGAKT | QNGVYSAANY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TNGSFGSNFV | SAGIQTSFRT | GNPTGTYQNG | YDSTQQYGSN | VANMHNGMNQ | QAYAYPLPQA |
| 610 | |||||
| APMIGYPMPT | GYSQ |