Q61655
Gene name |
Ddx19a (Ddx19, Eif4a-rs1) |
Protein name |
ATP-dependent RNA helicase DDX19A |
Names |
DEAD box RNA helicase DEAD5, mDEAD5, DEAD box protein 19A, Eukaryotic translation initiation factor 4A-related sequence 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13680 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
Autoinhibitory domains (AIDs)
Target domain |
124-294 (Helicase ATP-binding domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q61655
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61655-F1 | Predicted | AlphaFoldDB |
No variants for Q61655
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q61655 | |||||
No associated diseases with Q61655
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| poly(A)+ mRNA export from nucleus | The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBP1 | DDX25 | ATP-dependent RNA helicase DDX25 | Bos taurus (Bovine) | PR |
| Q3ZBV2 | DDX19A | ATP-dependent RNA helicase DDX19A | Bos taurus (Bovine) | SS |
| Q9UHL0 | DDX25 | ATP-dependent RNA helicase DDX25 | Homo sapiens (Human) | PR |
| Q9UMR2 | DDX19B | ATP-dependent RNA helicase DDX19B | Homo sapiens (Human) | PR |
| Q9NUU7 | DDX19A | ATP-dependent RNA helicase DDX19A | Homo sapiens (Human) | PR |
| Q91VC3 | Eif4a3 | Eukaryotic initiation factor 4A-III | Mus musculus (Mouse) | PR |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q9QY15 | Ddx25 | ATP-dependent RNA helicase DDX25 | Mus musculus (Mouse) | PR |
| Q501J6 | Ddx17 | Probable ATP-dependent RNA helicase DDX17 | Mus musculus (Mouse) | PR |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q91VN6 | Ddx41 | Probable ATP-dependent RNA helicase DDX41 | Mus musculus (Mouse) | PR |
| Q99MJ9 | Ddx50 | ATP-dependent RNA helicase DDX50 | Mus musculus (Mouse) | PR |
| Q61656 | Ddx5 | Probable ATP-dependent RNA helicase DDX5 | Mus musculus (Mouse) | PR |
| Q10RI7 | Os03g0158200 | DEAD-box ATP-dependent RNA helicase 38 | Oryza sativa subsp japonica (Rice) | PR |
| Q93ZG7 | RH38 | DEAD-box ATP-dependent RNA helicase 38 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATDSWALAV | DEQEAAVKSM | SSLQIKEEKV | KADTNGVIKT | STTAEKTEEE | EKEDRAAQSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNKLIRSNLV | DNTNQVEVLQ | RDPSSPLYSV | KSFEELRLKP | QLLQGVYAMG | FNRPSKIQEN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALPMMLAEPP | QNLIAQSQSG | TGKTAAFVLA | MLSRVEPADR | YPQCLCLSPT | YELALQTGKV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IEQMGKFHPE | LKLAYAVRGN | KLERGQKVSE | QIVIGTPGTV | LDWCSKLKFI | DPKKIKVFVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DEADVMIATQ | GHQDQSIRIQ | RMLPRNCQML | LFSATFEDSV | WKFAQKVVPD | PNIIKLKREE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ETLDTIKQYY | VLCNNREEKF | QALCNLYGAI | TIAQAMIFCH | TRKTASWLAA | ELSKEGHQVA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLSGEMMVEQ | RAAVIERFRE | GKEKVLVTTN | VCARGIDVEQ | VSVVINFDLP | VDKDGNPDNE |
| 430 | 440 | 450 | 460 | 470 | |
| TYLHRIGRTG | RFGKRGLAVN | MVDSKHSMNI | LNRIQEHFNK | KIERLDTDDL | DEIEKIAN |