Q61194

PR
Gene name
Pik3c2a (Cpk)
Protein name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Names
PI3K-C2-alpha, PtdIns-3-kinase C2 subunit alpha, Cpk-m, Phosphoinositide 3-kinase-C2-alpha, p170
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18704
EC number
2.7.1.137: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

1268-1292 (Activation loop from InterPro)

Target domain

1043-1395 (Catalytic domain of Class II Phosphoinositide 3-kinase alpha)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

9 structures for Q61194

Entry ID Method Resolution Chain Position Source
2B3R X-ray 230 A A/B 1561-1686 PDB
7BI2 X-ray 325 A PDB
7BI4 X-ray 242 A PDB
7BI6 X-ray 275 A PDB
7BI9 X-ray 265 A PDB
7Z74 X-ray 250 A PDB
7Z75 X-ray 259 A PDB
8A9I X-ray 287 A PDB
AF-Q61194-F1 Predicted AlphaFoldDB

No variants for Q61194

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q61194

No associated diseases with Q61194

10 regional properties for Q61194

Type Name Position InterPro Accession
domain C2 domain 1559 - 1680 IPR000008
domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain 410 - 513 IPR000341
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 1105 - 1396 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 860 - 1047 IPR001263
domain Phox homology 1422 - 1538 IPR001683
domain C2 phosphatidylinositol 3-kinase-type domain 674 - 841 IPR002420
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 1137 - 1151 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 1235 - 1255 IPR018936-2
domain PI3K-C2-alpha, catalytic domain 1043 - 1395 IPR037705
domain Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain 1426 - 1534 IPR042133

Functions

Description
EC Number 2.7.1.137 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cell membrane
  • Cytoplasmic vesicle, clathrin-coated vesicle
  • Nucleus
  • Cytoplasm
  • Golgi apparatus, trans-Golgi network
  • Inserts preferentially into membranes containing PtdIns(4,5)P2
  • Associated with RNA-containing structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

8 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
clathrin binding Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.
phosphatidylinositol-3,4-bisphosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).

14 GO annotations of biological process

Name Definition
autophagosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
macroautophagy The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
negative regulation of zinc ion transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other.
phosphatidylinositol 3-kinase signaling A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of cell migration involved in sprouting angiogenesis Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A1X283 SH3PXD2B SH3 and PX domain-containing protein 2B Homo sapiens (Human) EV
Q5TCZ1 SH3PXD2A SH3 and PX domain-containing protein 2A Homo sapiens (Human) SS
O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Homo sapiens (Human) PR
A2AAY5 Sh3pxd2b SH3 and PX domain-containing protein 2B Mus musculus (Mouse) SS
O89032 Sh3pxd2a SH3 and PX domain-containing protein 2A Mus musculus (Mouse) SS
Q8BKC8 Pi4kb Phosphatidylinositol 4-kinase beta Mus musculus (Mouse) PR
Q9JHG7 Pik3cg Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (Mouse) PR
P42337 Pik3ca Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (Mouse) PR
Q8BTI9 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Mus musculus (Mouse) PR
O35904 Pik3cd Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Mus musculus (Mouse) PR
10 20 30 40 50 60
MAQISNNSEF KQCSSSHPEP IRTKDVNKAE ALQMEAEALA KLQKDRQMTD SPRGFELSSS
70 80 90 100 110 120
TRQRTQGFNK QDYDLMVFPE LDSQKRAVDI DVEKLTQAEL EKILLDDNFE TRKPPALPVT
130 140 150 160 170 180
PVLSPSFSTQ LYLRPSGQRG QWPPGLCGPS TYTLPSTYPS AYSKQATFQN GFSPRMPTFP
190 200 210 220 230 240
STESVYLRLP GQSPYFSYPL TPATPFHPQG SLPVYRPLVS PDMAKLFEKI ASTSEFLKNG
250 260 270 280 290 300
KARTDLEIAN SKASVCNLQI SPKSEDINKF DWLDLDPLSK PKVDYVEVLE HEEEKKDPVL
310 320 330 340 350 360
LAEDPWDAVL LEERSPSCHL ERKVNGKSLS GATVTRSQSL IIRTAQFTKA QGQVSQKDPN
370 380 390 400 410 420
GTSSLPTGSS LLQEFEVQND EVAAFCQSIM KLKTKFPYTD HCTNPGYLLS PVTVQRNMCG
430 440 450 460 470 480
ENASVKVSIE IEGLQLPVTF TCDVSSTVEI IIMQALCWVH DDLNQVDVGS YILKVCGQEE
490 500 510 520 530 540
VLQNNHCLGS HEHIQNCRKW DTEIKLQLLT LSAMCQNLAR TAEDDEAPVD LNKYLYQIEK
550 560 570 580 590 600
PYKEVMTRHP VEELLDSYHY QVELALQTEN QHRAVDQVIK AVRKICSALD GVETPSVTEA
610 620 630 640 650 660
VKKLKRAVNL PRNKSADVTS LSGSDTRKNS TKGSLNPENP VQVSMDHLTT AIYDLLRLHA
670 680 690 700 710 720
NSSRCSTACP RGSRNIKEAW TATEQLQFTV YAAHGISSNW VSNYEKYYLI CSLSHNGKDL
730 740 750 760 770 780
FKPIQSKKVG TYKNFFYLIK WDELIIFPIQ ISQLPLESVL HLTLFGVLNQ SSGSSPDSNK
790 800 810 820 830 840
QRKGPEALGK VSLTLFDFKR FLTCGTKLLY LWTSSHTNSI PGAIPKKSYV MERIVLQVDF
850 860 870 880 890 900
PSPAFDIIYT SPQIDRNIIQ QDKLETLESD IKGKLLDIIH RDSSFGLSKE DKVFLWENRY
910 920 930 940 950 960
YCLKHPNCLP KILASAPNWK WANLAKTYSL LHQWPPLCPL AALELLDAKF ADQEVRSLAV
970 980 990 1000 1010 1020
SWMEAISDDE LADLLPQFVQ ALKYEIYLNS SLVRFLLSRA LGNIQIAHSL YWLLKDALHD
1030 1040 1050 1060 1070 1080
THFGSRYEHV LGALLSVGGK GLREELSKQM KLVQLLGGVA EKVRQASGST RQVVLQKSME
1090 1100 1110 1120 1130 1140
RVQSFFLRNK CRLPLKPSLV AKELNIKSCS FFSSNAMPLK VTMVNADPLG EEINVMFKVG
1150 1160 1170 1180 1190 1200
EDLRQDMLAL QMIKIMDKIW LKEGLDLRMV IFRCLSTGRD RGMVELVPAS DTLRKIQVEY
1210 1220 1230 1240 1250 1260
GVTGSFKDKP LAEWLRKYNP SEEEYEKASE NFIYSCAGCC VATYVLGICD RHNDNIMLRS
1270 1280 1290 1300 1310 1320
TGHMFHIDFG KFLGHAQMFG SFKRDRAPFV LTSDMAYVIN GGEKPTIRFQ LFVDLCCQAY
1330 1340 1350 1360 1370 1380
NLIRKQTNLF LNLLSLMIPS GLPELTSIQD LKYVRDALQP QTTDAEATIF FTRLIESSLG
1390 1400 1410 1420 1430 1440
SIATKFNFFI HNLAQLRFSG LPSNDEPILS FSPKTYSFRQ DGRIKEVSVF TYHKKYNPDK
1450 1460 1470 1480 1490 1500
HYIYVVRILR EGHLEPSFVF RTFDEFQELH NKLSIIFPLW KLPGFPNRMV LGRTHIKDVA
1510 1520 1530 1540 1550 1560
AKRKIELNSY LQSLMNASTD VAECDLVCTF FHPLLRDEKA EGIARSAGAV PFSPTLGQIG
1570 1580 1590 1600 1610 1620
GAVKLSVSYR NGTLFIMVMH IKDLVTEDGA DPNPYVKTYL LPDTHKTSKR KTKISRKTRN
1630 1640 1650 1660 1670 1680
PTFNEMLVYS GYSKETLRQR ELQLSVLSAE SLRENFFLGG ITLPLKDFNL SKETVKWYQL
TAATYL