Q61179
Gene name |
Irf9 (Isgf3g) |
Protein name |
Interferon regulatory factor 9 |
Names |
IRF-9, IFN-alpha-responsive transcription factor subunit, ISGF3 p48 subunit, Interferon-stimulated gene factor 3 gamma, ISGF-3 gamma, Transcriptional regulator ISGF3 subunit gamma |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:16391 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q61179
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5OEM | X-ray | 190 A | A | 197-385 | PDB |
| 5OEN | X-ray | 292 A | A | 206-376 | PDB |
| AF-Q61179-F1 | Predicted | AlphaFoldDB |
33 variants for Q61179
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389330106 | 11 | K>R | No | EVA | |
| rs255184508 | 18 | E>K | No | EVA | |
| rs255184508 | 18 | E>Q | No | EVA | |
| rs214378666 | 18 | E>V | No | EVA | |
| rs229786072 | 24 | H>Q | No | EVA | |
| rs3389326633 | 25 | F>I | No | EVA | |
| rs3389254298 | 28 | V>L | No | EVA | |
| rs3389284951 | 36 | T>A | No | EVA | |
| rs3389330512 | 41 | P>T | No | EVA | |
| rs3389333370 | 57 | A>V | No | EVA | |
| rs3405130177 | 66 | K>* | No | EVA | |
| rs3389333444 | 68 | K>R | No | EVA | |
| rs3389333394 | 76 | H>Q | No | EVA | |
| rs3389302705 | 82 | T>S | No | EVA | |
| rs3389334784 | 85 | R>S | No | EVA | |
| rs3389327547 | 94 | F>V | No | EVA | |
| rs3389295735 | 98 | P>T | No | EVA | |
| rs3389327495 | 107 | E>V | No | EVA | |
| rs3389334739 | 138 | V>M | No | EVA | |
| rs3389302623 | 139 | S>T | No | EVA | |
| rs3389284927 | 171 | S>N | No | EVA | |
| rs3389254255 | 210 | S>T | No | EVA | |
| rs3389341657 | 214 | L>Q | No | EVA | |
| rs3389321248 | 220 | Y>* | No | EVA | |
| rs245651704 | 244 | S>L | No | EVA | |
| rs3389254270 | 256 | P>S | No | EVA | |
| rs3389327273 | 257 | D>Y | No | EVA | |
| rs224740524 | 264 | H>R | No | EVA | |
| rs238648845 | 270 | D>E | No | EVA | |
| rs3389330102 | 287 | L>F | No | EVA | |
| rs3389330136 | 352 | S>Y | No | EVA | |
| rs3405125268 | 390 | T>P | No | EVA | |
| rs3405130123 | 393 | S>* | No | EVA |
No associated diseases with Q61179
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| ISGF3 complex | A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| immune system process | Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00978 | IRF9 | Interferon regulatory factor 9 | Homo sapiens (Human) | PR |
| P56477 | Irf5 | Interferon regulatory factor 5 | Mus musculus (Mouse) | SS |
| Q64287 | Irf4 | Interferon regulatory factor 4 | Mus musculus (Mouse) | EV |
| P70671 | Irf3 | Interferon regulatory factor 3 | Mus musculus (Mouse) | SS |
| P70434 | Irf7 | Interferon regulatory factor 7 | Mus musculus (Mouse) | SS |
| P23611 | Irf8 | Interferon regulatory factor 8 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASGKVRCTR | KLRSWIVEQV | ESGHFPGVCW | DDAAKTMFRI | PWKHAGKQDF | REDQDAAIFK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AWALFKEKHK | DGDIGHPAVW | KTRLRCALNK | SSEFEEVPER | GRMDVAEPYK | VYRILPAGTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PNQPRNQKSP | CKRSISCVSP | EREENMENGR | TNGVVNHSDS | GSNIGGGGNG | SNRSDSNSNC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSELEEGAGT | TEATIREDPV | FLEHQLPLNS | DYSLLLTFIY | GGRVVGKTQV | HSLDCRLVAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RSDSESSMEQ | VEFPKPDPLE | PTQHLLNQLD | RGVLVASNSR | GLFVQRLCPI | PISWNAPEAP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGPGPHLLPS | NKCVELFKTT | YFCRDLAQYF | QGQGPPPKFQ | ATLHFWEESP | GSSHSQENLI |
| 370 | 380 | 390 | |||
| TVQMEQAFAR | HLLEKIPEEE | KAALFLLQHT | EQSPSALGH |