Q61083

PR
Gene name
Map3k2 (Mekk2)
Protein name
Mitogen-activated protein kinase kinase kinase 2
Names
MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
2.7.11.25: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-428 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

500-526 (Activation loop from InterPro)

Target domain

356-616 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q61083

Entry ID Method Resolution Chain Position Source
AF-Q61083-F1 Predicted AlphaFoldDB

No variants for Q61083

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q61083

No associated diseases with Q61083

4 regional properties for Q61083

Type Name Position InterPro Accession
domain PB1 domain 43 - 122 IPR000270
domain Protein kinase domain 356 - 616 IPR000719
binding_site Protein kinase, ATP binding site 362 - 385 IPR017441
domain Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain 44 - 122 IPR034879

Functions

Description
EC Number 2.7.11.25 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Upon EGF stimulation, translocates into the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
metal ion binding Binding to a metal ion.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
protein phosphorylation The process of introducing a phosphate group on to a protein.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99759 MAP3K3 Mitogen-activated protein kinase kinase kinase 3 Homo sapiens (Human) PR
Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 Homo sapiens (Human) PR
Q61084 Map3k3 Mitogen-activated protein kinase kinase kinase 3 Mus musculus (Mouse) PR
Q9ES70 Nek6 Serine/threonine-protein kinase Nek6 Mus musculus (Mouse) SS
O22042 ANP3 Mitogen-activated protein kinase kinase kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKPSSPKK QNDVRVKFEH RGEKRILQVT
70 80 90 100 110 120
RPVKLEDLRS KSKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV
130 140 150 160 170 180
VNGSTQATNL EPSPSPEDLN NTPLGAERKK RLSVVGPPNR DRSSPPPGYI PDILHQIARN
190 200 210 220 230 240
GSFTSINSEG EFIPESMDQM LDPLSLSSPE NSGSGSCPSL DSPLDGESYP KSRMPRAQSY
250 260 270 280 290 300
PDNHQEFTDY DNPIFEKFGK GGTYPRRYHV SYHHQEYNDG RKTFPRARRT QGTSFRSPVS
310 320 330 340 350 360
FSPTDHSLST SSGSSVFTPE YDDSRIRRRG SDIDNPTLTV TDISPPSRSP RAPTNWRLGK
370 380 390 400 410 420
LLGQGAFGRV YLCYDVDTGR ELAVKQVQFN PESPETSKEV NALECEIQLL KNLLHERIVQ
430 440 450 460 470 480
YYGCLRDPQE KTLSIFMELS PGGSIKDQLK AYGALTENVT RKYTRQILEG VHYLHSNMIV
490 500 510 520 530 540
HRDIKGANIL RDSTGNIKLG DFGASKRLQT ICLSGTGMKS VTGTPYWMSP EVISGEGYGR
550 560 570 580 590 600
KADIWSVACT VVEMLTEKPP WAEFEAMAAI FKIATQPTNP KLPPHVSDYT RDFLKRIFVE
610
AKLRPSAEEL LRHMFVHYH